2. Gene
  3. ZMAT3 - zinc finger matrin-type 3 Gene

ZMAT3 - zinc finger matrin-type 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指基质 3 型

种属: Homo sapiens

同用名: WIG1; WIG-1; PAG608

基因 ID: 64393 | 基因类型: protein coding

关于 ZMAT3

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:179,017,223-179,072,513 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.2), gall bladder (RPKM 5.6) and 24 other tissues.

功能概要

该基因编码的蛋白质包含三个锌指结构域和一个核定位信号。该基因的 mRNA 和蛋白质被野生型 p53 上调，并且该基因的过表达抑制肿瘤细胞生长，表明该基因可能在 p53 依赖性生长调节途径中发挥作用。该基因的可变剪接导致两个转录变体编码两种同种型，仅在一个氨基酸上有所不同。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

ZMAT3 基因产物(8)

mRNA Protein Name
NM_001375824.1 NP_001362753.1 zinc finger matrin-type protein 3 isoform 1
NM_001375825.1 NP_001362754.1 zinc finger matrin-type protein 3 isoform 1
NM_001375826.1 NP_001362755.1 zinc finger matrin-type protein 3 isoform 2
NM_001375827.1 NP_001362756.1 zinc finger matrin-type protein 3 isoform 2
NM_001375828.1 NP_001362757.1 zinc finger matrin-type protein 3 isoform 2
NM_001375829.1 NP_001362758.1 zinc finger matrin-type protein 3 isoform 2
NM_022470.4 NP_071915.1 zinc finger matrin-type protein 3 isoform 1
NM_152240.3 NP_689426.1 zinc finger matrin-type protein 3 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18519039 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZMAT3 蛋白结构

zf-met

zf-met: Zinc-finger of C2H2 type (70 - 94)

zf-met

zf-met: Zinc-finger of C2H2 type (148 - 171)

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (245 - 271)

  • 0
  • 100
  • 200
  • 289 a.a.
蛋白主名 其他名称

zinc finger matrin-type protein 3

WIG-1/PAG608 protein

ZMAT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZMAT3 Q9HA38 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
18519039
Intra ZMAT3 Q9HA38 HNRNPA2B1 Homo sapiens P22626
Anti Bait CoIP
18519039
Intra ZMAT3 Q9HA38 DHX9 Homo sapiens Q08211
Anti Bait CoIP
18519039
Intra ZMAT3 Q9HA38 DHX9 Homo sapiens Q08211
Anti Tag CoIP
18519039
Intra ZMAT3 Q9HA38 STAU1 Homo sapiens O95793
Validated Y2H
25416956
Intra ZMAT3 Q9HA38 STAU1 Homo sapiens O95793
Y2H Prey Pooling
25416956
Intra ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Anti Bait CoIP
23085987
Intra ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Pull Down
23085987
Intra ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
23085987
Intra ZMAT3 Q9HA38 PRKRA Homo sapiens O75569
Y2H Array
25416956
Intra ZMAT3 Q9HA38 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra ZMAT3 Q9HA38 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra ZMAT3 Q9HA38 TARBP2 Homo sapiens Q15633
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16085 ZMAT3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZMAT3 MGD MGI:1195270
Bos taurus ZMAT3 VGNC VGNC:37192
Macaca mulatta ZMAT3 VGNC VGNC:79831
Canis familiaris ZMAT3 VGNC VGNC:48640
Felis catus ZMAT3 VGNC VGNC:67253
Rattus norvegicus ZMAT3 RGD RGD:620134
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