2. Gene
  3. PRKRA - protein activator of interferon induced protein kinase EIF2AK2 Gene

PRKRA - protein activator of interferon induced protein kinase EIF2AK2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素诱导蛋白激酶 EIF2AK2 的蛋白激活因子

种属: Homo sapiens

同用名: RAX; PACT; DYT16; HSD14

基因 ID: 8575 | 基因类型: protein coding

关于 PRKRA

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,431,414-178,451,175 (from NCBI)

This gene has 36 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 15.5), endometrium (RPKM 12.4) and 25 other tissues.

功能概要

该基因编码一种由双链 RNA 激活的蛋白激酶，它介导干扰素对病毒感染的反应。该基因的突变与肌张力障碍有关。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 11 月]

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral Infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

PRKRA 基因产物(4)

mRNA Protein Name
NM_001139517.1 NP_001132989.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2
NM_001139518.1 NP_001132990.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 3
NM_001316362.2 NP_001303291.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 4
NM_003690.5 NP_003681.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
23661684 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23661684 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
enables pre-miRNA binding IDA
IDA: 通过直接分析推断
23661684 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16424907 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
17452327 GOA
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
29170442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RISC complex assembly IDA
IDA: 通过直接分析推断
23661684 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
26454002 GOA
involved in miRNA processing IDA
IDA: 通过直接分析推断
23661684 GOA
involved in pre-miRNA processing IDA
IDA: 通过直接分析推断
16424907 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
16424907 GOA
involved in siRNA processing IDA
IDA: 通过直接分析推断
17452327 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RISC-loading complex IDA
IDA: 通过直接分析推断
23661684 GOA
part of RISC-loading complex IPI
IPI: 通过物理相互作用推断
23661684 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
22214662 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17452327 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKRA 蛋白结构

dsrm

dsrm: Double-stranded RNA binding motif (35 - 99)

dsrm

dsrm: Double-stranded RNA binding motif (127 - 191)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

interferon-inducible double-stranded RNA-dependent protein kinase activator A

PKR-associated protein X

PRKRA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKRA O75569 CEBPZ Homo sapiens Q03701
Anti Tag CoIP
33961781
Intra PRKRA O75569 ZMAT4 Homo sapiens Q9H898-2
Y2H Prey Pooling
32296183
Intra PRKRA O75569 ZMAT4 Homo sapiens Q9H898-2
Validated Y2H
32296183
Intra PRKRA O75569 ZMAT4 Homo sapiens Q9H898-2
Complementation
32296183
Intra PRKRA O75569 ZMAT4 Homo sapiens Q9H898-2
Y2H Array
32296183
Intra PRKRA O75569 ADARB1 Homo sapiens P78563-4
Y2H Array
32296183
Intra PRKRA O75569 ADARB1 Homo sapiens P78563-4
Y2H Prey Pooling
32296183
Intra PRKRA O75569 ADARB1 Homo sapiens P78563-4
Validated Y2H
32296183
Intra PRKRA O75569 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Cross PRKRA O75569 N SARS-CoV-2 P0DTC9
Confocal
35075101
Cross PRKRA O75569 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
Cross PRKRA O75569 N SARS-CoV-2 P0DTC9
Anti Tag CoIP
35075101
Intra PRKRA O75569 ZMAT3 Homo sapiens Q9HA38
Validated Y2H
25416956
Intra PRKRA O75569 ZMAT3 Homo sapiens Q9HA38
Y2H Prey Pooling
25416956
Intra PRKRA O75569 PIAS2 Homo sapiens O75928-2
Validated Y2H
32296183
Intra PRKRA O75569 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra PRKRA O75569 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra PRKRA O75569 STAU1 Homo sapiens O95793
Anti Tag CoIP
33961781
Intra PRKRA O75569 STAU1 Homo sapiens O95793
Y2H Prey Pooling
32296183
Intra PRKRA O75569 STAU1 Homo sapiens O95793
Validated Y2H
32296183
Intra PRKRA O75569 STAU1 Homo sapiens O95793
Y2H Array
32296183
Intra PRKRA O75569 DICER1 Homo sapiens Q9UPY3
Anti Tag CoIP
16424907
Intra PRKRA O75569 DICER1 Homo sapiens Q9UPY3
Anti Tag CoIP
33961781
Intra PRKRA O75569 IFIH1 Homo sapiens Q9BYX4
Anti Tag CoIP
28591694
Intra PRKRA O75569 EIF2AK2 Homo sapiens P19525
Y2H Prey Pooling
32296183
Intra PRKRA O75569 EIF2AK2 Homo sapiens P19525
Validated Y2H
32296183
Intra PRKRA O75569 EIF2AK2 Homo sapiens P19525
Y2H Array
32296183
Intra PRKRA O75569 LYAR Homo sapiens Q9NX58
Y2H Array
31515488
Intra PRKRA O75569 LYAR Homo sapiens Q9NX58
Validated Y2H
25416956
Intra PRKRA O75569 LYAR Homo sapiens Q9NX58
Anti Tag CoIP
33961781
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Anti Tag CoIP
33961781
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Validated Y2H
32296183
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H Array
25416956
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H
21900206
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H Array
32296183
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Validated Y2H
25910212
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H Bait-Prey Pool
25910212
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H Array
25910212
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Anti Tag CoIP
16424907
Intra PRKRA O75569 TARBP2 Homo sapiens Q15633
Y2H Prey Pooling
32296183
Intra PRKRA O75569 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra PRKRA O75569 STRBP Homo sapiens Q96SI9
Validated Y2H
32296183
Cross PRKRA O75569 N Human SARS coronavirus P59595
Confocal
28591694
Cross PRKRA O75569 N Human SARS coronavirus P59595
Anti Tag CoIP
28591694
Intra PRKRA O75569 NKRF Homo sapiens O15226
Anti Tag CoIP
33961781
Intra PRKRA O75569 RIGI Homo sapiens O95786
Anti Tag CoIP
23870315
Intra PRKRA O75569 RIGI Homo sapiens O95786
Anti Tag CoIP
28591694
Cross PRKRA O75569 PA Influenza A virus Q67020
Y2H
21994455
Cross PRKRA O75569 NS Influenza A virus P03496
Y2H Array
23853584
Cross PRKRA O75569 NS Influenza A virus P03496
Y2H
20064372
Cross PRKRA O75569 N Murine coronavirus P03416
Anti Tag CoIP
28591694
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dystonia 16

DYT16

Dyt-Prkra

Dystonia-16

Young-Onset Dystonia-

Early-Onset Dystonia Parkinsonism

Dystonia, Type 16
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Multifocal Dystonia
Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis
Spasmodic Dystonia

Laryngeal Dystonia
Dystonia, Dopa-Responsive

Dystonia 5

Dopa-Responsive Dystonia

DRD

Dyt5

Dystonia-Parkinsonism With Diurnal Fluctuation

Dyt-Th

Hpd With Diurnal Fluctuation

Hereditary Progressive Dystonia With Diurnal Fluctuation

Dystonia, Progressive, With Diurnal Variation

Segawa Syndrome, Autosomal Dominant

Dystonia, Dopa-Responsive, Autosomal Dominant

Dopa-Responsive Dystonia, Autosomal Dominant

Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia

Dyt-Gch1

Dyt-Spr

Dystonia 5, Dopa-Responsive Type

Hereditary Progressive Dystonia With Marked Diurnal Fluctuation

Autosomal Dominant Dopa-Responsive Dystonia

Autosomal Dominant Segawa Syndrome

Dystonia-5

Progressive Dystonia With Diurnal Fluctuation

Dystonia, Type 5, Dopa-Responsive Type
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]
Cervical Dystonia

Spasmodic Torticollis
Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3

RCDP3

Alkyldihydroxyacetonephosphate Synthase Deficiency

Alkylglycerone-Phosphate Synthase Deficiency

Agps Deficiency

Rhizomelic Chondrodysplasia Punctata 3

Chondrodysplasia Punctata, Rhizomelic, Type 3
Segmental Dystonia
Acute Ethmoiditis

Acute Ethmoidal Sinusitis

Acute Ethmoid Sinusitis

Ethmoidal Sinus - Acute
Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3
Deafness, Autosomal Recessive 109

DFNB109

Autosomal Recessive Nonsyndromic Deafness 109

Autosomal Recessive Deafness 109

Deafness, Autosomal Recessive, 109
Focal Dystonia

Dystonia, Focal, Task-Specific
Paraneoplastic Polyneuropathy
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
Alternating Hemiplegia Of Childhood

Alternating Hemiplegia

Ahc

Alternating Hemiplegia Syndrome

Hemiplegia, Alternating, Of Childhood

Hemiplegia, Crossed
Movement Disease

Movement Disorders

Movement Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11157 PRKRA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKRA MGD MGI:1344375
Rattus norvegicus PRKRA RGD RGD:1306707
Canis familiaris PRKRA VGNC VGNC:44991
Bos taurus PRKRA VGNC VGNC:33343
Macaca mulatta PRKRA VGNC VGNC:76421
Felis catus PRKRA VGNC VGNC:69073
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