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  2. CEBPZ - CCAAT enhancer binding protein zeta Gene

CEBPZ - CCAAT enhancer binding protein zeta Gene

中文名称:CCAAT 增强子结合蛋白 zeta

种属: Homo sapiens

同用名: CBF; CBF2; NOC1; HSP-CBF

基因 ID: 10153 | 基因类型: protein coding

关于 CEBPZ

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,201,612-37,231,596 (from NCBI)

This gene has 3 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 27.1), adrenal (RPKM 18.8) and 25 other tissues.

功能概要

该基因属于 CBF/Mak21 家族。编码的蛋白质通过涉及热休克因子、保守 DNA 元件 (热休克元件或 HSE) 和 CCAAT 盒的转录过程在细胞对环境刺激的反应中发挥作用。该蛋白质充当 DNA 结合转录激活剂,并以 CCAAT 依赖性方式调节热休克蛋白 70 (HSP70) 启动子。该蛋白质还参与细胞生长和分化,特别是造血分化。[RefSeq 提供,2020 年 11 月]

This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]

CEBPZ 基因产物(1)

mRNA Protein Name
NM_005760.3 NP_005751.2 CCAAT/enhancer-binding protein zeta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA binding IDA
IDA: 通过直接分析推断
11306579 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21900206 GOA
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
11306579 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
2247079 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11306579 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CEBPZ 蛋白结构

CBF

CBF: CBF/Mak21 family (522 - 732)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1054 a.a.
蛋白主名 其他名称

CCAAT/enhancer-binding protein zeta

CCAAT-box-binding transcription factor

CEBPZ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CEBPZ Q03701 PRKRA Homo sapiens O75569
Y2H
21900206
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Opportunistic Bacterial Infectious Disease
Nocardiosis

Nocardia Infection

Nocardia Infections

Nocardia Infectious Disease

Lung Nocardiosis

Nocardiasis

Nocardiosis Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CEBPZ VGNC VGNC:71082
Felis catus CEBPZ VGNC VGNC:60741
Mus musculus CEBPZ MGD MGI:109386
Canis familiaris CEBPZ VGNC VGNC:39090
Rattus norvegicus CEBPZ RGD RGD:1304994
Bos taurus CEBPZ VGNC VGNC:27164