DHX9 - DExH-box helicase 9 Gene

中文名称：DExH-box 解旋酶 9

种属: Homo sapiens

同用名: LKP; RHA; DDX9; NDH2; NDHII

基因 ID: 1660 | 基因类型: protein coding

关于 DHX9

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,839,347-182,887,982 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 54.5), testis (RPKM 36.3) and 25 other tissues.

功能概要

该基因编码含有 DEAH 的 RNA 解旋酶家族成员。编码的蛋白质是一种酶，可催化双链 RNA 和 DNA-RNA 复合物的 ATP 依赖性解旋。该蛋白质定位于细胞核和细胞质，并作为转录调节因子发挥作用。这种蛋白质也可能参与逆转录病毒 RNA 的表达和核输出。交替剪接导致多个转录本变体。该基因的假基因存在于 11 号和 13 号染色体上。[RefSeq 提供，2010 年 2 月]

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an Enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

DHX9 基因产物(1)

mRNA	Protein	Name
NM_001357.5	NP_001348.2	ATP-dependent RNA helicase A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5' DNA helicase activity	IDA IDA: 通过直接分析推断	21561811	GOA
enables 3'-5' DNA/RNA helicase activity	IDA IDA: 通过直接分析推断	1537828	GOA
enables 3'-5' RNA helicase activity	IDA IDA: 通过直接分析推断	1537828	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	11416126	GOA
enables ATP hydrolysis activity	IMP IMP: 通过突变表型推断	11416126	GOA
enables DNA helicase activity	IMP IMP: 通过突变表型推断	12711669	GOA
enables DNA replication origin binding	IDA IDA: 通过直接分析推断	24990949	GOA
enables RISC complex binding	IDA IDA: 通过直接分析推断	17531811	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	1537828	GOA
enables RNA helicase activity	IDA IDA: 通过直接分析推断	28221134	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	11038348	GOA
enables RNA polymerase II complex binding	IDA IDA: 通过直接分析推断	11416126	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17303075	GOA
enables RNA polymerase binding	IDA IDA: 通过直接分析推断	9323138	GOA
enables RNA stem-loop binding	IDA IDA: 通过直接分析推断	11096080	GOA
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	24049074	GOA
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	9111062	GOA
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	9111062	GOA
enables importin-alpha family protein binding	IDA IDA: 通过直接分析推断	16375861	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	10198287	GOA
enables mRNA binding	IMP IMP: 通过突变表型推断	28221134	GOA
enables nucleoside triphosphate diphosphatase activity	IDA IDA: 通过直接分析推断	1537828	GOA
enables promoter-specific chromatin binding	IMP IMP: 通过突变表型推断	28221134	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9323138	GOA
enables regulatory region RNA binding	IDA IDA: 通过直接分析推断	28355180	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	16680162	GOA
enables sequence-specific mRNA binding	IDA IDA: 通过直接分析推断	9162007	GOA
enables siRNA binding	IDA IDA: 通过直接分析推断	23361462	GOA
enables single-stranded 3'-5' DNA helicase activity	IDA IDA: 通过直接分析推断	20669935	GOA
enables single-stranded DNA binding	IDA IDA: 通过直接分析推断	9111062	GOA
enables single-stranded RNA binding	IDA IDA: 通过直接分析推断	9111062	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	9323138	GOA
enables transcription coregulator activity	IMP IMP: 通过突变表型推断	11416126	GOA
enables triplex DNA binding	IDA IDA: 通过直接分析推断	24049074	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CRD-mediated mRNA stabilization	IDA IDA: 通过直接分析推断	19029303	GOA
involved in CRD-mediated mRNA stabilization	IMP IMP: 通过突变表型推断	19029303	GOA
involved in DNA duplex unwinding	IDA IDA: 通过直接分析推断	9111062	GOA
involved in DNA duplex unwinding	IMP IMP: 通过突变表型推断	12711669	GOA
involved in DNA-templated viral transcription	IDA IDA: 通过直接分析推断	11096080	GOA
involved in G-quadruplex DNA unwinding	IDA IDA: 通过直接分析推断	21561811	GOA
involved in RISC complex assembly	IMP IMP: 通过突变表型推断	17531811	GOA
involved in RNA secondary structure unwinding	IDA IDA: 通过直接分析推断	1537828	GOA
involved in alternative mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	28221134	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: 通过突变表型推断	21957149	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: 通过突变表型推断	15355351	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IMP IMP: 通过突变表型推断	17531811	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	19029303	GOA
involved in positive regulation of DNA repair	IMP IMP: 通过突变表型推断	24049074	GOA
involved in positive regulation of DNA replication	IMP IMP: 通过突变表型推断	24990949	GOA
involved in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	IMP IMP: 通过突变表型推断	12711669	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	15355351	GOA
involved in positive regulation of RNA export from nucleus	IDA IDA: 通过直接分析推断	11402034	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: 通过直接分析推断	19029303	GOA
involved in positive regulation of cytoplasmic translation	IMP IMP: 通过突变表型推断	16680162	GOA
involved in positive regulation of fibroblast proliferation	IMP IMP: 通过突变表型推断	24990949	GOA
involved in positive regulation of interferon-alpha production	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	20696886	GOA
involved in positive regulation of response to cytokine stimulus	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	9323138	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	20696886	GOA
involved in positive regulation of viral transcription	IDA IDA: 通过直接分析推断	11096080	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: 通过突变表型推断	24965446	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	23361462	GOA
involved in regulation of cytoplasmic translation	IDA IDA: 通过直接分析推断	28355180	GOA
involved in regulation of mRNA processing	IDA IDA: 通过直接分析推断	28355180	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	9662397	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CRD-mediated mRNA stability complex	IDA IDA: 通过直接分析推断	19029303	GOA
part of CRD-mediated mRNA stability complex	IPI IPI: 通过物理相互作用推断	19029303	GOA
part of RISC complex	IDA IDA: 通过直接分析推断	17531811	GOA
part of RISC-loading complex	IMP IMP: 通过突变表型推断	17531811	GOA
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	11687588	GOA
located in centrosome	IDA IDA: 通过直接分析推断	17498979	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	9162007	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: 通过直接分析推断	10198287	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19029303	GOA
located in nuclear body	IDA IDA: 通过直接分析推断	28221134	GOA
located in nuclear stress granule	IDA IDA: 通过直接分析推断	10198287	GOA
located in nuclear stress granule	IMP IMP: 通过突变表型推断	24965446	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	28221134	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9162007	GOA
located in perichromatin fibrils	IDA IDA: 通过直接分析推断	10198287	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	11687588	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	11402034	GOA
part of ribonucleoprotein complex	IMP IMP: 通过突变表型推断	28221134	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHX9 蛋白结构

dsrm

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
800
1000
1200
1270 a.a.

蛋白主名

其他名称

ATP-dependent RNA helicase A

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9

DHX9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	DHX9	Q08211	HNRNPA2B1	Homo sapiens	P22626	Anti Bait CoIP	18519039
Intra	DHX9	Q08211	HNRNPA2B1	Homo sapiens	P22626	Anti Tag CoIP	35271311
Intra	DHX9	Q08211	YBX1	Homo sapiens	P67809	Anti Bait CoIP	21849455
Intra	DHX9	Q08211	YBX1	Homo sapiens	P67809	Anti Tag CoIP	35271311
Intra	DHX9	Q08211	YBX1	Homo sapiens	P67809	Anti Bait CoIP	23986595
Intra	DHX9	Q08211	XPO1	Homo sapiens	O14980	Anti Bait CoIP	19955415
Intra	DHX9	Q08211	NXF1	Homo sapiens	Q9UBU9	Anti Bait CoIP	10924507
Intra	DHX9	Q08211	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	35271311
Intra	DHX9	Q08211	RELA	Homo sapiens	Q04206	CoIP	15355351
Intra	DHX9	Q08211	RELA	Homo sapiens	Q04206	Anti Tag CoIP	15355351
Intra	DHX9	Q08211	RELA	Homo sapiens	Q04206	Pull Down	15355351
Intra	DHX9	Q08211	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	35271311
Intra	DHX9	Q08211	PRMT1	Homo sapiens	Q99873	Pull Down	15084609
Cross	DHX9	Q08211	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Pull Down	24965446
Cross	DHX9	Q08211	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	IF	24965446

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Parkinson Disease 22, Autosomal Dominant

PARK22	Parkinson'S Disease 22
Autosomal Dominant Parkinson'S Disease 22	Parkinson Disease 22

Abnormal Retinal Correspondence

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-156784	ATX968	Inhibitor	98.83%	否
HY-156782	DHX9-IN-1	Inhibitor	98.74%	否
HY-160007	DHX9-IN-3	Inhibitor	99.78%	否
HY-157602	DHX9-IN-8	Inhibitor	/	否
HY-157603	DHX9-IN-7	Inhibitor	/	否
HY-157604	DHX9-IN-9	Inhibitor	/	否
HY-157605	DHX9-IN-11	Inhibitor	/	否
HY-157606	DHX9-IN-13	Inhibitor	/	否
HY-157607	DHX9-IN-15	Inhibitor	/	否
HY-157608	DHX9-IN-10	Inhibitor	/	否
HY-157609	DHX9-IN-12	Inhibitor	/	否
HY-157610	DHX9-IN-14	Inhibitor	/	否
HY-157611	DHX9-IN-17	Inhibitor	/	否
HY-157612	DHX9-IN-16	Inhibitor	/	否
HY-160008	DHX9-IN-4	Inhibitor	/	否
HY-160009	DHX9-IN-5	Inhibitor	/	否
HY-160010	DHX9-IN-6	Inhibitor	/	否
HY-RS03761	DHX9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DHX9	MGD	MGI:108177
Bos taurus	DHX9	VGNC	VGNC:28060
Felis catus	DHX9	VGNC	VGNC:61488
Rattus norvegicus	DHX9	RGD	RGD:1308548
Macaca mulatta	DHX9	VGNC	VGNC:71766
Canis familiaris	DHX9	VGNC	VGNC:39953
Others	DHX9	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DHX9 - DExH-box helicase 9 Gene

关于 DHX9

功能概要

DHX9 基因产物(1)

DHX9 蛋白结构

DHX9 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DHX9 - DExH-box helicase 9 Gene

关于 DHX9

功能概要

DHX9 基因产物(1)

DHX9 蛋白结构

DHX9 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z