YBX1 - Y-box binding protein 1 Gene

中文名称：Y-box 结合蛋白 1

种属: Homo sapiens

同用名: YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1

基因 ID: 4904 | 基因类型: protein coding

关于 YBX1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,682,418-42,703,805 (from NCBI)

This gene has 4 transcripts (splice variants), 343 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 220.6), fat (RPKM 121.2) and 25 other tissues.

功能概要

该基因编码高度保守的冷休克结构域蛋白，具有广泛的核酸结合特性。编码的蛋白质作为 DNA 和 RNA 结合蛋白发挥作用，并与许多细胞过程有关，包括转录和翻译的调节、pre-mRNA 剪接、DNA 修复和 mRNA 包装。这种蛋白质也是信使核糖核蛋白 (mRNP) 复合物的组成部分，可能在 MicroRNA 加工中发挥作用。这种蛋白质可以通过非经典途径分泌，并起到细胞外有丝分裂原的作用。该基因的异常表达与许多组织中的癌症增殖有关。该基因可能是某些癌症预后不良和耐药性的预后标志物。交替剪接导致多个转录本变体。该基因的假基因存在于多条染色体上。[RefSeq 提供，2015 年 9 月]

This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in MicroRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with Cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

YBX1 基因产物(2)

mRNA	Protein	Name
NM_004559.5	NP_004550.2	Y-box-binding protein 1
NM_004559.5	NP_004550.2	Y-box-binding protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: 通过直接分析推断	31358969	GOA
enables GTPase binding	IPI IPI: 通过物理相互作用推断	24337748	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	19561594	GOA
enables miRNA binding	IDA IDA: 通过直接分析推断	27559612	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12674497	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CRD-mediated mRNA stabilization	IDA IDA: 通过直接分析推断	19029303	GOA
involved in CRD-mediated mRNA stabilization	IMP IMP: 通过突变表型推断	19029303	GOA
involved in RNA transport	IMP IMP: 通过突变表型推断	29073095	GOA
involved in mRNA stabilization	IDA IDA: 通过直接分析推断	31358969	GOA
involved in miRNA transport	IDA IDA: 通过直接分析推断	27559612	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	19029303	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: 通过直接分析推断	19029303	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18809583	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: 通过突变表型推断	24965446	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18809583	GOA
involved in tRNA transport	IMP IMP: 通过突变表型推断	29073095	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CRD-mediated mRNA stability complex	IDA IDA: 通过直接分析推断	19029303	GOA
part of CRD-mediated mRNA stability complex	IPI IPI: 通过物理相互作用推断	19029303	GOA
part of U12-type spliceosomal complex	IDA IDA: 通过直接分析推断	15146077	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24965446	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	18335541	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19029303	GOA
located in extracellular exosome	IDA IDA: 通过直接分析推断	27559612	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	17289661	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YBX1 蛋白结构

CSD

0
100
200
300
324 a.a.

蛋白主名

其他名称

Y-box-binding protein 1

CCAAT-binding transcription factor I subunit A

YBX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	YBX1	P67809	PITX2	Homo sapiens	Q99697	Anti Bait CoIP	19174163
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Confocal	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	23986595
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	35271311
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	TAP	22118625
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Bait CoIP	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	33961781
Intra	YBX1	P67809	LSM3	Homo sapiens	P62310	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	21849455
Intra	YBX1	P67809	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	16797541
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Pull Down	12674497
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Y2H	12674497
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	TAP	24981860
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Anti Tag CoIP	16797541
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Pull Down	16797541
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	IF	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Anti Bait CoIP	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Pull Down	24965446
Cross	YBX1	P67809	CTCF	Gallus gallus	Q08705	Pull Down	15229244

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Liposarcoma

Lipomatous Cancer

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16252	Ybx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15916	YBX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	YBX1	RGD	RGD:61843
Bos taurus	YBX1	VGNC	VGNC:50233
Mus musculus	YBX1	MGD	MGI:99146
Macaca mulatta	YBX1	VGNC	VGNC:100189
Felis catus	YBX1	VGNC	VGNC:80405
Others	YBX1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

YBX1 - Y-box binding protein 1 Gene

关于 YBX1

功能概要

YBX1 基因产物(2)

YBX1 蛋白结构

YBX1 蛋白互作信息

关联疾病

直系同源

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YBX1 - Y-box binding protein 1 Gene

关于 YBX1

功能概要

YBX1 基因产物(2)

YBX1 蛋白结构

YBX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

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