NXF1 - nuclear RNA export factor 1 Gene

中文名称：核 RNA 输出因子 1

种属: Homo sapiens

同用名: TAP; MEX67

关于 NXF1

功能概要

该基因是核 RNA 输出因子基因家族的成员之一。该家族的共同结构域特征是非经典 RNP 型 RNA 结合结构域 (RBD) 、4 个富含亮氨酸的重复序列 (LRR) 、允许与 NTF2 相关输出蛋白异二聚化的核转运因子 2 (NTF2) 样结构域- 1 (NXT1) ，以及介导与核孔蛋白相互作用的泛素相关结构域。出口活动需要 LRR 和类似 NTF2 的域。可变剪接似乎是该基因家族中的一种常见机制。该基因编码的蛋白质在细胞核和细胞质之间穿梭，并在体内与 poly (A) + RNA 结合。它是酵母蛋白 Mex67p 的脊椎动物同系物。编码的蛋白质克服了由饱和量的 D 型逆转录病毒 CTE (组成型转运元件) RNA 引起的 mRNA 输出阻滞。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 7 月]

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]