2. Gene
  3. CHTOP - chromatin target of PRMT1 Gene

CHTOP - chromatin target of PRMT1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PRMT1 的染色质目标

种属: Homo sapiens

同用名: FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG; C10orf77

基因 ID: 26097 | 基因类型: protein coding

关于 CHTOP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,634,066-153,646,306 (from NCBI)

This gene has 7 transcripts (splice variants), 261 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.4), spleen (RPKM 20.4) and 25 other tissues.

功能概要

该基因编码一种小的核蛋白，其特征在于富含精氨酸和甘氨酸的区域。这种蛋白质可能在胎儿珠蛋白基因表达的调节和雌激素反应基因的激活中起重要作用。最近的一项研究报告说，这种蛋白质结合 5-羟甲基胞嘧啶 (5hmC) 并与精氨酸甲基转移酶复合物 (甲基体) 结合，后者促进组蛋白 H4 (H4R3) 精氨酸 3 的甲基化和参与胶质母细胞瘤发生的基因的激活。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2015 年 11 月]

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

CHTOP 基因产物(4)

mRNA Protein Name
NM_001206612.2 NP_001193541.1 chromatin target of PRMT1 protein isoform 2
NM_001244664.2 NP_001231593.1 chromatin target of PRMT1 protein isoform 3
NM_001317077.2 NP_001304006.1 chromatin target of PRMT1 protein isoform 4
NM_015607.4 NP_056422.2 chromatin target of PRMT1 protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
25284789 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14667819 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
25284789 GOA
involved in mRNA export from nucleus IDA
IDA: 通过直接分析推断
23299939 GOA
involved in positive regulation of ATP-dependent activity IDA
IDA: 通过直接分析推断
23299939 GOA
involved in positive regulation of helicase activity IDA
IDA: 通过直接分析推断
23299939 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
23299939 GOA
part of transcription export complex IDA
IDA: 通过直接分析推断
23299939 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHTOP 蛋白结构

FoP_duplication

FoP_duplication: C-terminal duplication domain of Friend of PRMT1 (178 - 244)

  • 0
  • 100
  • 200
  • 248 a.a.
蛋白主名 其他名称

chromatin target of PRMT1 protein

friend of PRMT1 protein

CHTOP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CHTOP Q9Y3Y2 ALYREF Homo sapiens Q86V81
Anti Tag CoIP
23299939
Intra CHTOP Q9Y3Y2 ALYREF Homo sapiens Q86V81
Pull Down
23299939
Intra CHTOP Q9Y3Y2 ALYREF Homo sapiens Q86V81
Anti Bait CoIP
23299939
Intra CHTOP Q9Y3Y2 DDX39B Homo sapiens Q13838
Anti Bait CoIP
23299939
Intra CHTOP Q9Y3Y2 DDX39B Homo sapiens Q13838
Anti Tag CoIP
23299939
Intra CHTOP Q9Y3Y2 DDX39B Homo sapiens Q13838
Anti Tag CoIP
33961781
Intra CHTOP Q9Y3Y2 DDX39B Homo sapiens Q13838
Pull Down
23299939
Intra CHTOP Q9Y3Y2 SMN1 Homo sapiens Q16637
Y2H Prey Pooling
25416956
Intra CHTOP Q9Y3Y2 SMN1 Homo sapiens Q16637
Validated Y2H
25416956
Intra CHTOP Q9Y3Y2 SMN1 Homo sapiens Q16637
Y2H Array
25416956
Intra CHTOP Q9Y3Y2 NXF1 Homo sapiens Q9UBU9
Anti Tag CoIP
23299939
Intra CHTOP Q9Y3Y2 NXF1 Homo sapiens Q9UBU9
Pull Down
23299939
Intra CHTOP Q9Y3Y2 ERH Homo sapiens P84090
Y2H Array
25416956
Intra CHTOP Q9Y3Y2 ERH Homo sapiens P84090
Anti Tag CoIP
33961781
Intra CHTOP Q9Y3Y2 ERH Homo sapiens P84090
Y2H Prey Pooling
25416956
Intra CHTOP Q9Y3Y2 ERH Homo sapiens P84090
Crosslink
30021884
Intra CHTOP Q9Y3Y2 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
Intra CHTOP Q9Y3Y2 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra CHTOP Q9Y3Y2 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
33961781
Intra CHTOP Q9Y3Y2 PRMT1 Homo sapiens Q99873
Anti Bait CoIP
19858291
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Dominant Beta Thalassemia

Inclusion Body Beta-Thalassemia
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Farmer'S Lung

Farmer Lung

Farmers Lung

Farmer'S Lung Disease

Farmers' Lung

Farmers' Lung Disease

Mouldy Hay Disease

Moldy Hay Disorder

Fibrosis Of Lung With Farmers' Lung

Harvesters' Hypersensitivity Pneumonitis

Moldy Hay Pneumoconiosis

Haymakers' Hypersensitivity Pneumonitis

Threshers' Lung

Harvester Lung

Haymaker Lung
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02697 CHTOP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CHTOP VGNC VGNC:53336
Bos taurus CHTOP VGNC VGNC:27353
Macaca mulatta CHTOP VGNC VGNC:71090
Mus musculus CHTOP MGD MGI:1913761
Rattus norvegicus CHTOP RGD RGD:1359407
Felis catus CHTOP VGNC VGNC:107858
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z