2. Gene
  3. ALYREF - Aly/REF export factor Gene

ALYREF - Aly/REF export factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Aly/REF 导出因子

种属: Homo sapiens

同用名: ALY; BEF; REF; THOC4; ALY/REF

基因 ID: 10189 | 基因类型: protein coding

关于 ALYREF

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,887,835-81,891,587 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 44.1), testis (RPKM 33.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种热稳定的核蛋白，起着分子伴侣的作用。它被认为可以调节碱性区域亮氨酸拉链 (bZIP) 蛋白的二聚化、DNA 结合和转录活性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

ALYREF 基因产物(1)

mRNA Protein Name
NM_005782.4 NP_005773.3 THO complex subunit 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C5-methylcytidine-containing RNA reader activity IDA
IDA: 通过直接分析推断
28418038 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11546874 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA export from nucleus IDA
IDA: 通过直接分析推断
28418038 GOA
involved in mRNA export from nucleus IMP
IMP: 通过突变表型推断
17190602 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
28418038 GOA
part of exon-exon junction complex IDA
IDA: 通过直接分析推断
16314458 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28418038 GOA
part of transcription export complex IDA
IDA: 通过直接分析推断
15833825 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALYREF 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (108 - 176)

FoP_duplication

FoP_duplication: C-terminal duplication domain of Friend of PRMT1 (202 - 251)

  • 0
  • 100
  • 200
  • 257 a.a.
蛋白主名 其他名称

THO complex subunit 4

THO complex 4

ALYREF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Anti Bait CoIP
23299939
Intra ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Pull Down
23299939
Intra ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Anti Tag CoIP
23299939
Intra ALYREF Q86V81 DDX39B Homo sapiens Q13838
Anti Bait CoIP
23299939
Intra ALYREF Q86V81 DDX39B Homo sapiens Q13838
Anti Tag CoIP
23299939
Intra ALYREF Q86V81 NXF1 Homo sapiens Q9UBU9
Anti Tag CoIP
23299939
Intra ALYREF Q86V81 NXF1 Homo sapiens Q9UBU9
Pull Down
23299939
Cross ALYREF Q86V81 mta_hhv8p Human herpesvirus 8 Q2HR75
IF
19850040
Cross ALYREF Q86V81 mta_hhv8p Human herpesvirus 8 Q2HR75
Pull Down
19850040
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy

Patterned Macular Dystrophy 3

MDPT3

Mcrpe
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00639 ALYREF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ALYREF VGNC VGNC:37823
Rattus norvegicus ALYREF RGD RGD:1594679
Felis catus ALYREF VGNC VGNC:59762
Macaca mulatta ALYREF VGNC VGNC:69635
Bos taurus ALYREF VGNC VGNC:25855
Mus musculus ALYREF MGD MGI:1341044
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