NUP62 - nucleoporin 62 Gene

中文名称：核孔蛋白 62

种属: Homo sapiens

同用名: p62; IBSN; SNDI

基因 ID: 23636 | 基因类型: protein coding

关于 NUP62

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,906,825-49,929,504 (from NCBI)

This gene has 28 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues.

功能概要

核孔复合体是一个巨大的结构，延伸穿过核膜，形成调节细胞核和细胞质之间大分子流动的通道。核孔蛋白是真核细胞核孔复合体的主要成分。由该基因编码的蛋白质是含有核孔蛋白的 FG 重复序列的成员，定位于核孔中央栓塞。这种蛋白质与参与含有核定位信号的蛋白质输入的输入蛋白 alpha/beta 复合体相关。该基因的多个转录变体编码单个蛋白质亚型。[RefSeq 提供，2008 年 7 月]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

NUP62 基因产物(5)

mRNA	Protein	Name
NM_001193357.2	NP_001180286.1	nuclear pore glycoprotein p62
NM_012346.5	NP_036478.2	nuclear pore glycoprotein p62
NM_016553.5	NP_057637.2	nuclear pore glycoprotein p62
NM_153718.4	NP_714940.1	nuclear pore glycoprotein p62
NM_153719.4	NP_714941.1	nuclear pore glycoprotein p62

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	7744965	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	10799545	GOA
involved in centriole assembly	IMP IMP: 通过突变表型推断	24107630	GOA
involved in centrosome cycle	IMP IMP: 通过突变表型推断	24107630	GOA
involved in mitotic centrosome separation	IMP IMP: 通过突变表型推断	24107630	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: 通过突变表型推断	24107630	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11013214	GOA
involved in positive regulation of centriole replication	IMP IMP: 通过突变表型推断	24107630	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: 通过突变表型推断	24107630	GOA
involved in positive regulation of mitotic nuclear division	IMP IMP: 通过突变表型推断	24107630	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: 通过突变表型推断	24107630	GOA
involved in regulation of mitotic spindle organization	IMP IMP: 通过突变表型推断	24107630	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Flemming body	IDA IDA: 通过直接分析推断	19166812	GOA
located in centrosome	IDA IDA: 通过直接分析推断	24107630	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24107630	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	24107630	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	17098863	GOA
part of nuclear pore	IDA IDA: 通过直接分析推断	1915414	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	24107630	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP62 蛋白结构

Nsp1_C

0
100
200
300
400
522 a.a.

蛋白主名

其他名称

nuclear pore glycoprotein p62

62 kDa nucleoporin

NUP62 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NUP62	P37198	SSC5D	Homo sapiens	A1L4H1	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	SSC5D	Homo sapiens	A1L4H1	Y2H Array	25416956
种属内	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
种属内	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
种属内	NUP62	P37198	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
种属内	NUP62	P37198	HSF2	Homo sapiens	Q03933-2	Y2H Array	25416956
种属内	NUP62	P37198	HSF2	Homo sapiens	Q03933-2	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	BFSP1	Homo sapiens	Q12934	Validated Y2H	25416956
种属内	NUP62	P37198	XPO6	Homo sapiens	Q96QU8	Y2H Array	29892012
种属内	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Y2H Array	25416956
种属内	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Validated Y2H	25416956
种属内	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KLHL32	Homo sapiens	Q5THT1	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KLHL32	Homo sapiens	Q5THT1	Validated Y2H	25416956
种属内	NUP62	P37198	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
种属内	NUP62	P37198	q9h614_human	Homo sapiens	Q9H614	Y2H Array	25416956
种属内	NUP62	P37198	ISCU	Homo sapiens	Q9H1K1	Validated Y2H	32296183
种属内	NUP62	P37198	ISCU	Homo sapiens	Q9H1K1	Y2H Array	25416956
种属内	NUP62	P37198	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
种属内	NUP62	P37198	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
种属内	NUP62	P37198	OTUD6A	Homo sapiens	Q7L8S5	Validated Y2H	32296183
种属内	NUP62	P37198	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
种属内	NUP62	P37198	DPPA3	Homo sapiens	Q6W0C5	Validated Y2H	32296183
种属内	NUP62	P37198	TLE4	Homo sapiens	Q04727-2	Validated Y2H	32296183
种属内	NUP62	P37198	BFSP1	Homo sapiens	Q12934-2	Validated Y2H	32296183
种属内	NUP62	P37198	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
种属内	NUP62	P37198	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	CENPU	Homo sapiens	Q71F23	Anti Tag CoIP	33961781
种属内	NUP62	P37198	CENPU	Homo sapiens	Q71F23	Validated Y2H	25416956
种属内	NUP62	P37198	HSF2	Homo sapiens	Q03933	Y2H Array	31515488
种属内	NUP62	P37198	HSF2	Homo sapiens	Q03933	Y2H Array	25416956
种属内	NUP62	P37198	HSF2	Homo sapiens	Q03933	Validated Y2H	25416956
种属内	NUP62	P37198	IKBIP	Homo sapiens	Q70UQ0	Y2H Array	25416956
种属内	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Anti Tag CoIP	33961781
种属内	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Array	31515488
种属内	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Array	25416956
种属内	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Validated Y2H	25416956
种属内	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Y2H Array	25416956
种属内	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	TXLNA	Homo sapiens	P40222	Validated Y2H	32296183
种属内	NUP62	P37198	CAVIN3	Homo sapiens	Q969G5	Validated Y2H	32296183
种属内	NUP62	P37198	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
种属内	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Validated Y2H	25416956
种属内	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
种属内	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	32296183
种属内	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Anti Bait CoIP	23477864
种属内	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
种属内	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Pull Down	10668806
种属内	NUP62	P37198	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
种属内	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
种属内	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
种属内	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
种属内	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	25416956
种属内	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Y2H Array	25416956
种属内	NUP62	P37198	OIP5	Homo sapiens	O43482	Validated Y2H	25416956
种属内	NUP62	P37198	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
种属内	NUP62	P37198	NUTF2	Homo sapiens	P61970	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
种属内	NUP62	P37198	FABP3	Homo sapiens	P05413	Y2H	21516116
种属内	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	25416956
种属内	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	16189514
种属内	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
种属内	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
种属内	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	25416956
种属内	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
种属内	NUP62	P37198	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
种属内	NUP62	P37198	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
种属内	NUP62	P37198	NUP88	Homo sapiens	Q99567	Anti Tag CoIP	33961781
种属内	NUP62	P37198	NUP88	Homo sapiens	Q99567	Validated Y2H	32296183
种属内	NUP62	P37198	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	LMO2	Homo sapiens	P25791	Y2H Array	25416956
种属内	NUP62	P37198	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
种属内	NUP62	P37198	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	NUP62	P37198	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
种属内	NUP62	P37198	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
种属内	NUP62	P37198	DTNB	Homo sapiens	O60941	Validated Y2H	25416956
种属内	NUP62	P37198	DTNB	Homo sapiens	O60941	Y2H Array	25416956
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H	21516116
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Pooling	16189514
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	31515488
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Anti Tag CoIP	33961781
种属内	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Y2H	21516116
种属内	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Y2H Pooling	16189514
种属内	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
种属内	NUP62	P37198	MXD3	Homo sapiens	Q9BW11	Validated Y2H	32296183
种属内	NUP62	P37198	KRT20	Homo sapiens	P35900	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	KRT20	Homo sapiens	P35900	Y2H Array	25416956
种属内	NUP62	P37198	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
种属内	NUP62	P37198	IFT20	Homo sapiens	Q8IY31	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Y2H Array	31515488
种属内	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	25416956
种属内	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	32296183
种属内	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Anti Tag CoIP	33961781
种属内	NUP62	P37198	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
种属内	NUP62	P37198	SNAPC5	Homo sapiens	O75971	Validated Y2H	25416956
种属内	NUP62	P37198	SNAPC5	Homo sapiens	O75971	Y2H Array	25416956
种属内	NUP62	P37198	ADAM15	Homo sapiens	Q13444	Validated Y2H	25416956
种属内	NUP62	P37198	ADAM15	Homo sapiens	Q13444	Y2H Prey Pooling	25416956
种属内	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31	Y2H Array	29892012
种属内	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31	Anti Tag CoIP	33961781
种属间	NUP62	P37198	icp27_hhv11	Human herpesvirus 1	P10238	Anti Bait CoIP	22334672

种属间: 跨种属相互作用 种属内: 同种属相互作用

NUP62 抗体

目录号	产品名	应用	反应物种
HY-P83252	Nucleoporin p62 Antibody (YA2997)	WB	Human

关联疾病

疾病名称

别名

Striatonigral Degeneration, Infantile

Infantile Bilateral Striatal Necrosis	Ibsn
SNDI	Striatonigral Degeneration Infantile
Infantile Striatonigral Degeneration	Bilateral Striatal Necrosis, Infantile
Striatal Degeneration, Familial	Striatal Degeneration Familial
Infantile Striatonigral Necrosis	Familial Striatal Degeneration

Familial Infantile Bilateral Striatal Necrosis

Familial Ibsn	Familial Infantile Striatonigral Degeneration
Familial Infantile Striatonigral Necrosis

Striatonigral Degeneration

Mitochondrial Complex I Deficiency, Nuclear Type 16

MC1DN16	Nuclear Type Mitochondrial Complex I Deficiency 16
Mitochondrial Complex 1 Deficiency, Nuclear Type 16

Cranioectodermal Dysplasia 4

CED4	Sensenbrenner Syndrome 4
Dysplasia, Cranioectodermal, Type 4

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Hydrolethalus Syndrome 1

Hydrolethalus Syndrome	HLS1
Salonen-Herva-Norio Syndrome	Hls
Hydrolethalus	Hydrolethalus Syndrome, Type 1

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09697	NUP62 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NUP62	RGD	RGD:619938
Canis familiaris	NUP62	VGNC	VGNC:44059
Bos taurus	NUP62	VGNC	VGNC:106850
Mus musculus	NUP62	MGD	MGI:1351500

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