2. Gene
  3. NUP62 - nucleoporin 62 Gene

NUP62 - nucleoporin 62 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核孔蛋白 62

种属: Homo sapiens

同用名: p62; IBSN; SNDI

基因 ID: 23636 | 基因类型: protein coding

关于 NUP62

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,906,825-49,929,504 (from NCBI)

This gene has 28 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues.

功能概要

核孔复合体是一个巨大的结构，延伸穿过核膜，形成调节细胞核和细胞质之间大分子流动的通道。核孔蛋白是真核细胞核孔复合体的主要成分。由该基因编码的蛋白质是含有核孔蛋白的 FG 重复序列的成员，定位于核孔中央栓塞。这种蛋白质与参与含有核定位信号的蛋白质输入的输入蛋白 alpha/beta 复合体相关。该基因的多个转录变体编码单个蛋白质亚型。[RefSeq 提供，2008 年 7 月]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

NUP62 基因产物(5)

mRNA Protein Name
NM_001193357.2 NP_001180286.1 nuclear pore glycoprotein p62
NM_012346.5 NP_036478.2 nuclear pore glycoprotein p62
NM_016553.5 NP_057637.2 nuclear pore glycoprotein p62
NM_153718.4 NP_714940.1 nuclear pore glycoprotein p62
NM_153719.4 NP_714941.1 nuclear pore glycoprotein p62
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7744965 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
10799545 GOA
involved in centriole assembly IMP
IMP: 通过突变表型推断
24107630 GOA
involved in centrosome cycle IMP
IMP: 通过突变表型推断
24107630 GOA
involved in mitotic centrosome separation IMP
IMP: 通过突变表型推断
24107630 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
24107630 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11013214 GOA
involved in positive regulation of centriole replication IMP
IMP: 通过突变表型推断
24107630 GOA
involved in positive regulation of mitotic cytokinetic process IMP
IMP: 通过突变表型推断
24107630 GOA
involved in positive regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
24107630 GOA
involved in positive regulation of protein localization to centrosome IMP
IMP: 通过突变表型推断
24107630 GOA
involved in regulation of mitotic spindle organization IMP
IMP: 通过突变表型推断
24107630 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Flemming body IDA
IDA: 通过直接分析推断
19166812 GOA
located in centrosome IDA
IDA: 通过直接分析推断
24107630 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
24107630 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
24107630 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
17098863 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
1915414 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
18809582 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
24107630 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP62 蛋白结构

Nsp1_C

Nsp1_C: Nsp1-like C-terminal region (323 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

nuclear pore glycoprotein p62

62 kDa nucleoporin

NUP62 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NUP62 P37198 SSC5D Homo sapiens A1L4H1
Y2H Prey Pooling
25416956
Intra NUP62 P37198 SSC5D Homo sapiens A1L4H1
Y2H Array
25416956
Intra NUP62 P37198 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra NUP62 P37198 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra NUP62 P37198 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra NUP62 P37198 HSF2 Homo sapiens Q03933-2
Y2H Array
25416956
Intra NUP62 P37198 HSF2 Homo sapiens Q03933-2
Y2H Prey Pooling
25416956
Intra NUP62 P37198 BFSP1 Homo sapiens Q12934
Validated Y2H
25416956
Intra NUP62 P37198 XPO6 Homo sapiens Q96QU8
Y2H Array
29892012
Intra NUP62 P37198 DRC12 Homo sapiens Q494R4
Y2H Array
25416956
Intra NUP62 P37198 DRC12 Homo sapiens Q494R4
Validated Y2H
25416956
Intra NUP62 P37198 DRC12 Homo sapiens Q494R4
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KLHL32 Homo sapiens Q5THT1
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KLHL32 Homo sapiens Q5THT1
Validated Y2H
25416956
Intra NUP62 P37198 CCDC146 Homo sapiens Q8IYE0-2
Y2H Array
25416956
Intra NUP62 P37198 q9h614_human Homo sapiens Q9H614
Y2H Array
25416956
Intra NUP62 P37198 ISCU Homo sapiens Q9H1K1
Validated Y2H
32296183
Intra NUP62 P37198 ISCU Homo sapiens Q9H1K1
Y2H Array
25416956
Intra NUP62 P37198 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra NUP62 P37198 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra NUP62 P37198 OTUD6A Homo sapiens Q7L8S5
Validated Y2H
32296183
Intra NUP62 P37198 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra NUP62 P37198 DPPA3 Homo sapiens Q6W0C5
Validated Y2H
32296183
Intra NUP62 P37198 TLE4 Homo sapiens Q04727-2
Validated Y2H
32296183
Intra NUP62 P37198 BFSP1 Homo sapiens Q12934-2
Validated Y2H
32296183
Intra NUP62 P37198 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra NUP62 P37198 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra NUP62 P37198 CENPU Homo sapiens Q71F23
Anti Tag CoIP
33961781
Intra NUP62 P37198 CENPU Homo sapiens Q71F23
Validated Y2H
25416956
Intra NUP62 P37198 HSF2 Homo sapiens Q03933
Y2H Array
31515488
Intra NUP62 P37198 HSF2 Homo sapiens Q03933
Y2H Array
25416956
Intra NUP62 P37198 HSF2 Homo sapiens Q03933
Validated Y2H
25416956
Intra NUP62 P37198 IKBIP Homo sapiens Q70UQ0
Y2H Array
25416956
Intra NUP62 P37198 NUP58 Homo sapiens Q9BVL2
Anti Tag CoIP
33961781
Intra NUP62 P37198 NUP58 Homo sapiens Q9BVL2
Y2H Array
31515488
Intra NUP62 P37198 NUP58 Homo sapiens Q9BVL2
Y2H Prey Pooling
25416956
Intra NUP62 P37198 NUP58 Homo sapiens Q9BVL2
Y2H Array
25416956
Intra NUP62 P37198 CCDC121 Homo sapiens Q6ZUS5
Validated Y2H
25416956
Intra NUP62 P37198 CCDC121 Homo sapiens Q6ZUS5
Y2H Array
25416956
Intra NUP62 P37198 CCDC121 Homo sapiens Q6ZUS5
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KPNA2 Homo sapiens P52292
Y2H Prey Pooling
25416956
Intra NUP62 P37198 TXLNA Homo sapiens P40222
Validated Y2H
32296183
Intra NUP62 P37198 CAVIN3 Homo sapiens Q969G5
Validated Y2H
32296183
Intra NUP62 P37198 SUOX Homo sapiens P51687
Validated Y2H
32296183
Intra NUP62 P37198 AGR3 Homo sapiens Q8TD06
Validated Y2H
25416956
Intra NUP62 P37198 AGR3 Homo sapiens Q8TD06
Y2H Prey Pooling
25416956
Intra NUP62 P37198 AGR3 Homo sapiens Q8TD06
Validated Y2H
32296183
Intra NUP62 P37198 NXF1 Homo sapiens Q9UBU9
Y2H Prey Pooling
25416956
Intra NUP62 P37198 NXF1 Homo sapiens Q9UBU9
Y2H Prey Pooling
32296183
Intra NUP62 P37198 NXF1 Homo sapiens Q9UBU9
Anti Bait CoIP
23477864
Intra NUP62 P37198 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra NUP62 P37198 NXF1 Homo sapiens Q9UBU9
Pull Down
10668806
Intra NUP62 P37198 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
Intra NUP62 P37198 SMARCE1 Homo sapiens Q969G3
Y2H Prey Pooling
25416956
Intra NUP62 P37198 SMARCE1 Homo sapiens Q969G3
Validated Y2H
25416956
Intra NUP62 P37198 SMARCE1 Homo sapiens Q969G3
Y2H Array
25416956
Intra NUP62 P37198 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
32296183
Intra NUP62 P37198 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
25416956
Intra NUP62 P37198 BLOC1S6 Homo sapiens Q9UL45
Y2H Prey Pooling
25416956
Intra NUP62 P37198 BLOC1S6 Homo sapiens Q9UL45
Y2H Array
25416956
Intra NUP62 P37198 OIP5 Homo sapiens O43482
Validated Y2H
25416956
Intra NUP62 P37198 NUTF2 Homo sapiens P61970
Validated Y2H
32296183
Intra NUP62 P37198 NUTF2 Homo sapiens P61970
Y2H Prey Pooling
25416956
Intra NUP62 P37198 ARFIP2 Homo sapiens P53365
Validated Y2H
32296183
Intra NUP62 P37198 FABP3 Homo sapiens P05413
Y2H
21516116
Intra NUP62 P37198 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
25416956
Intra NUP62 P37198 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25416956
Intra NUP62 P37198 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
Intra NUP62 P37198 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra NUP62 P37198 CRCT1 Homo sapiens Q9UGL9
Validated Y2H
32296183
Intra NUP62 P37198 CRCT1 Homo sapiens Q9UGL9
Y2H Array
25416956
Intra NUP62 P37198 CRCT1 Homo sapiens Q9UGL9
Y2H Prey Pooling
25416956
Intra NUP62 P37198 PIN1 Homo sapiens Q13526
Validated Y2H
32296183
Intra NUP62 P37198 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra NUP62 P37198 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra NUP62 P37198 NUP88 Homo sapiens Q99567
Anti Tag CoIP
33961781
Intra NUP62 P37198 NUP88 Homo sapiens Q99567
Validated Y2H
32296183
Intra NUP62 P37198 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra NUP62 P37198 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra NUP62 P37198 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra NUP62 P37198 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra NUP62 P37198 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra NUP62 P37198 KANSL1 Homo sapiens Q7Z3B3
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KANSL1 Homo sapiens Q7Z3B3
Validated Y2H
25416956
Intra NUP62 P37198 DTNB Homo sapiens O60941
Validated Y2H
25416956
Intra NUP62 P37198 DTNB Homo sapiens O60941
Y2H Array
25416956
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Y2H
21516116
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Y2H Pooling
16189514
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Y2H Array
31515488
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Validated Y2H
32296183
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Anti Tag CoIP
33961781
Intra NUP62 P37198 NUP54 Homo sapiens Q7Z3B4
Y2H Prey Pooling
25416956
Intra NUP62 P37198 THAP1 Homo sapiens Q9NVV9
Y2H
21516116
Intra NUP62 P37198 THAP1 Homo sapiens Q9NVV9
Y2H Pooling
16189514
Intra NUP62 P37198 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra NUP62 P37198 MXD3 Homo sapiens Q9BW11
Validated Y2H
32296183
Intra NUP62 P37198 KRT20 Homo sapiens P35900
Y2H Prey Pooling
25416956
Intra NUP62 P37198 KRT20 Homo sapiens P35900
Y2H Array
25416956
Intra NUP62 P37198 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra NUP62 P37198 IFT20 Homo sapiens Q8IY31
Y2H Prey Pooling
25416956
Intra NUP62 P37198 PHF21A Homo sapiens Q96BD5
Y2H Array
31515488
Intra NUP62 P37198 PHF21A Homo sapiens Q96BD5
Validated Y2H
25416956
Intra NUP62 P37198 PHF21A Homo sapiens Q96BD5
Validated Y2H
32296183
Intra NUP62 P37198 PHF21A Homo sapiens Q96BD5
Y2H Prey Pooling
25416956
Intra NUP62 P37198 PHF21A Homo sapiens Q96BD5
Anti Tag CoIP
33961781
Intra NUP62 P37198 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Intra NUP62 P37198 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra NUP62 P37198 SNAPC5 Homo sapiens O75971
Validated Y2H
25416956
Intra NUP62 P37198 SNAPC5 Homo sapiens O75971
Y2H Array
25416956
Intra NUP62 P37198 ADAM15 Homo sapiens Q13444
Validated Y2H
25416956
Intra NUP62 P37198 ADAM15 Homo sapiens Q13444
Y2H Prey Pooling
25416956
Intra NUP62 P37198 CCHCR1 Homo sapiens Q8TD31
Y2H Array
29892012
Intra NUP62 P37198 CCHCR1 Homo sapiens Q8TD31
Anti Tag CoIP
33961781
Cross NUP62 P37198 icp27_hhv11 Human herpesvirus 1 P10238
Anti Bait CoIP
22334672
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Striatonigral Degeneration, Infantile

Infantile Bilateral Striatal Necrosis

Ibsn

SNDI

Striatonigral Degeneration Infantile

Infantile Striatonigral Degeneration

Bilateral Striatal Necrosis, Infantile

Striatal Degeneration, Familial

Striatal Degeneration Familial

Infantile Striatonigral Necrosis

Familial Striatal Degeneration
Familial Infantile Bilateral Striatal Necrosis

Familial Ibsn

Familial Infantile Striatonigral Degeneration

Familial Infantile Striatonigral Necrosis
Striatonigral Degeneration
Mitochondrial Complex I Deficiency, Nuclear Type 16

MC1DN16

Nuclear Type Mitochondrial Complex I Deficiency 16

Mitochondrial Complex 1 Deficiency, Nuclear Type 16
Cranioectodermal Dysplasia 4

CED4

Sensenbrenner Syndrome 4

Dysplasia, Cranioectodermal, Type 4
Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome

Triple-A Syndrome

Achalasia-Addisonianism-Alacrimia Syndrome

Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

Triple A Syndrome

Aaa Syndrome

AAAS

Glucocorticoid Deficiency With Achalasia

Glucocorticoid Deficiency And Achalasia

Addisonian-Achalasia Syndrome

Hypoadrenalism With Achalasia

Alacrima-Achalasia-Addisonianism

Aaa

Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

Achalasia Addisonianism Alacrimia Syndrome

Achalasia Alacrima Syndrome

Addisonian Achalasia Syndrome

Achalasia-Addisonian Syndrome

Achalasia-Alacrima Syndrome

2a Syndrome

3a Syndrome

4a Syndrome

Adrenal Insufficiency-Achalasia-Alacrima Syndrome

Double A Syndrome

Quaternary A Syndrome

Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

Allgrove'S Syndrome

Adrenal Gland Hypofunction

Adrenal Cortical Hypofunction
Hydrolethalus Syndrome 1

Hydrolethalus Syndrome

HLS1

Salonen-Herva-Norio Syndrome

Hls

Hydrolethalus

Hydrolethalus Syndrome, Type 1
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09697 NUP62 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NUP62 RGD RGD:619938
Canis familiaris NUP62 VGNC VGNC:44059
Bos taurus NUP62 VGNC VGNC:106850
Mus musculus NUP62 MGD MGI:1351500
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