1. Gene
  2. PELI2 - pellino E3 ubiquitin protein ligase family member 2 Gene

PELI2 - pellino E3 ubiquitin protein ligase family member 2 Gene

中文名称:pellino E3 泛素蛋白连接酶家族成员 2

种属: Homo sapiens

基因 ID: 57161 | 基因类型: protein coding

关于 PELI2

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:56,118,411-56,301,524 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

预计可启用蛋白质-大分子接头活性和泛素蛋白连接酶活性。在 MAPK 级联的正调节和蛋白质磷酸化的正调节的上游或内部起作用。预测位于膜中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein Ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

PELI2 基因产物(1)

mRNA Protein Name
NM_021255.3 NP_067078.1 E3 ubiquitin-protein ligase pellino homolog 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12860405 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
12804775 GOA
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
12804775 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PELI2 蛋白结构

Pellino

Pellino: Pellino (5 - 420)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase pellino homolog 2

RING-type E3 ubiquitin transferase pellino homolog 2

PELI2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PELI2 Q9HAT8 SP4 Homo sapiens Q02446
Y2H Array
32296183
种属内
PELI2 Q9HAT8 SP4 Homo sapiens Q02446
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
种属内
PELI2 Q9HAT8 REL Homo sapiens Q04864-2
Y2H Array
32296183
种属内
PELI2 Q9HAT8 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
种属内
PELI2 Q9HAT8 OR7D2 Homo sapiens Q96RA2
Y2H Array
32296183
种属内
PELI2 Q9HAT8 OR7D2 Homo sapiens Q96RA2
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 PCGF2 Homo sapiens P35227
Y2H Array
32296183
种属内
PELI2 Q9HAT8 PCGF2 Homo sapiens P35227
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 TP63 Homo sapiens Q9H3D4
Y2H Array
32296183
种属内
PELI2 Q9HAT8 TP63 Homo sapiens Q9H3D4
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 HYAL2 Homo sapiens Q12891
Y2H Array
32296183
种属内
PELI2 Q9HAT8 HYAL2 Homo sapiens Q12891
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48
Validated Y2H
32296183
种属内
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48
Y2H Array
32296183
种属内
PELI2 Q9HAT8 MEOX1 Homo sapiens P50221
Y2H Array
32296183
种属内
PELI2 Q9HAT8 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 NUP62 Homo sapiens P37198
Y2H Array
32296183
种属内
PELI2 Q9HAT8 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617
Anti Bait CoIP
16884718
种属内
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617
Protein Kinase Assay
12860405
种属内
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617
CoIP
12860405
种属内
PELI2 Q9HAT8 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
种属内
PELI2 Q9HAT8 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 IRAK4 Homo sapiens Q9NWZ3
CoIP
12860405
种属内
PELI2 Q9HAT8 IRAK4 Homo sapiens Q9NWZ3
Y2H
12860405
种属内
PELI2 Q9HAT8 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
种属内
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03
Y2H Array
32296183
种属内
PELI2 Q9HAT8 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
32296183
种属内
PELI2 Q9HAT8 TRIM32 Homo sapiens Q13049
Y2H Array
32296183
种属内
PELI2 Q9HAT8 TMEM79 Homo sapiens Q9BSE2
Y2H Array
32296183
种属内
PELI2 Q9HAT8 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PELI2 MGD MGI:1891445
Macaca mulatta PELI2 VGNC VGNC:75939
Rattus norvegicus PELI2 RGD RGD:1565884
Bos taurus PELI2 VGNC VGNC:32741
Felis catus PELI2 VGNC VGNC:68784
Canis familiaris PELI2 VGNC VGNC:44415
Others PELI2 NCBI