HYAL2 - hyaluronidase 2 Gene

中文名称：透明质酸酶 2

种属: Homo sapiens

同用名: LUCA2

基因 ID: 8692 | 基因类型: protein coding

关于 HYAL2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,317,808-50,322,745 (from NCBI)

This gene has 10 transcripts (splice variants), 294 orthologues, 4 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues.

功能概要

该基因编码弱酸活性透明质酸酶。编码的蛋白质在结构上与其他更活跃的透明质酸酶相似。透明质酸酶降解透明质酸，透明质酸是细胞外基质的主要糖胺聚糖之一。乙酰透明质酸和乙酰透明质酸片段被认为参与细胞增殖、迁移和分化。虽然它以前被认为是一种溶酶体透明质酸酶，在 pH 值低于 4 时具有活性，但编码的蛋白质可能是 GPI 锚定细胞表面蛋白。这种透明质酸酶充当致癌病毒 Jaagsiekte 绵羊逆转录病毒的受体。该基因是染色体 3p21.3 区域与肿瘤抑制相关的几个相关基因之一。该基因编码两个选择性剪接的转录本变体，它们仅在 5' UTR 不同。[RefSeq 提供，2010 年 3 月]

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to Other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2 基因产物(2)

mRNA	Protein	Name
NM_003773.5	NP_003764.3	hyaluronidase-2 precursor
NM_033158.5	NP_149348.2	hyaluronidase-2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	19366691	GOA
enables hyaluronic acid binding	IDA IDA: 通过直接分析推断	12676986	GOA
enables hyaluronoglucuronidase activity	IDA IDA: 通过直接分析推断	21699545	GOA
NOT enables hyalurononglucosaminidase activity	IDA IDA: 通过直接分析推断	11296287	GOA
enables hyalurononglucosaminidase activity	IDA IDA: 通过直接分析推断	9712871	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12676986	GOA
enables receptor signaling protein tyrosine kinase inhibitor activity	IDA IDA: 通过直接分析推断	12676986	GOA
enables receptor tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	12676986	GOA
enables virus receptor activity	IDA IDA: 通过直接分析推断	11296287	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cartilage development	IEP IEP: 通过表达模式推断	11944887	GOA
involved in cellular response to UV-B	IDA IDA: 通过直接分析推断	21699545	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: 通过直接分析推断	19577615	GOA
involved in cellular response to interleukin-1	IDA IDA: 通过直接分析推断	18390475	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: 通过直接分析推断	19366691	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: 通过表达模式推断	18390475	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: 通过直接分析推断	11296287	GOA
involved in glycosaminoglycan catabolic process	IDA IDA: 通过直接分析推断	9712871	GOA
involved in hyaluronan catabolic process	IDA IDA: 通过直接分析推断	17170110	GOA
involved in monocyte activation	IDA IDA: 通过直接分析推断	19443707	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	12676986	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	18725949	GOA
involved in negative regulation of fibroblast migration	IDA IDA: 通过直接分析推断	19577615	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	12676986	GOA
involved in negative regulation of protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	12676986	GOA
involved in positive regulation of inflammatory response	IDA IDA: 通过直接分析推断	19443707	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: 通过直接分析推断	19443707	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: 通过直接分析推断	19443707	GOA
involved in response to antibiotic	IEP IEP: 通过表达模式推断	11944887	GOA
involved in response to reactive oxygen species	IDA IDA: 通过直接分析推断	20554532	GOA
involved in response to virus	IDA IDA: 通过直接分析推断	11296287	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	20554532	GOA
located in cell surface	IDA IDA: 通过直接分析推断	17170110	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17170110	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	16600643	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19366691	GOA
located in endocytic vesicle	IDA IDA: 通过直接分析推断	19366691	GOA
colocalizes with external side of plasma membrane	IDA IDA: 通过直接分析推断	19443707	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	11296287	GOA
located in lysosome	IDA IDA: 通过直接分析推断	9712871	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	21740893	GOA
located in microvillus	IDA IDA: 通过直接分析推断	19366691	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16600643	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18390475	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HYAL2 蛋白结构

Glyco_hydro_56

0
100
200
300
400
473 a.a.

蛋白主名

其他名称

hyaluronidase-2

PH-20 homolog

HYAL2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HYAL2	Q12891	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	KRT34	Homo sapiens	O76011	Y2H Array	32296183
种属内	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
种属内	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
种属内	HYAL2	Q12891	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
种属内	HYAL2	Q12891	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
种属内	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
种属内	HYAL2	Q12891	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
种属内	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
种属内	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
种属内	HYAL2	Q12891	APP	Homo sapiens	P05067-2	Y2H Array	32814053
种属内	HYAL2	Q12891	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
种属内	HYAL2	Q12891	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	HYAL2	Q12891	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	PON2	Homo sapiens	Q15165	Anti Tag CoIP	33961781
种属内	HYAL2	Q12891	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
种属内	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
种属内	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
种属内	HYAL2	Q12891	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
种属内	HYAL2	Q12891	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
种属内	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
种属内	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Y2H Array	32814053
种属内	HYAL2	Q12891	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
种属内	HYAL2	Q12891	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	25416956
种属内	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
种属内	HYAL2	Q12891	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome

Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Deafness Syndrome

Hyaluronidase 2 Deficiency

Cor Triatriatum

Triatrial Heart

Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix	Hyaluronidase Deficiency
MPS9	Mps Ix
Mucopolysaccharidosis Ix	Mpsix
Mucopolysaccharidosis Type 9	Mucopolysaccharidosis 9

Bronchiolo-Alveolar Adenocarcinoma

Bronchioloalveolar Carcinoma	Bronchioalveolar Lung Carcinoma
Minimally Invasive Lung Adenocarcinoma	Carcinoma Bronchioloalveolar
Adenocarcinoma, Bronchiolo-Alveolar	Bronchioloalveolar Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06496	HYAL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HYAL2	RGD	RGD:620321
Bos taurus	HYAL2	VGNC	VGNC:30011
Mus musculus	HYAL2	MGD	MGI:1196334
Canis familiaris	HYAL2	VGNC	VGNC:41843
Felis catus	HYAL2	VGNC	VGNC:67679
Macaca mulatta	HYAL2	VGNC	VGNC:73548
Others	HYAL2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HYAL2 - hyaluronidase 2 Gene

关于 HYAL2

功能概要

HYAL2 基因产物(2)

HYAL2 蛋白结构

HYAL2 蛋白互作信息

关联疾病

直系同源

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HYAL2 - hyaluronidase 2 Gene

关于 HYAL2

功能概要

HYAL2 基因产物(2)

HYAL2 蛋白结构

HYAL2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z