2. Gene
  3. RMDN3 - regulator of microtubule dynamics 3 Gene

RMDN3 - regulator of microtubule dynamics 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管动力学调节器 3

种属: Homo sapiens

同用名: RMD3; RMD-3; FAM82C; FAM82A2; ptpip51

基因 ID: 55177 | 基因类型: protein coding

关于 RMDN3

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,735,887-40,755,254 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 16.9), lung (RPKM 14.6) and 25 other tissues.

功能概要

启用微管结合活动。参与细胞钙离子稳态。位于多个细胞成分中，包括细胞间桥；线粒体外膜；和主轴。 [由基因组资源联盟提供，2022 年 4 月]

Enables microtubule binding activity. Involved in cellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

RMDN3 基因产物(6)

mRNA Protein Name
NM_001304802.2 NP_001291731.1 regulator of microtubule dynamics protein 3 isoform 1
NM_001323894.2 NP_001310823.1 regulator of microtubule dynamics protein 3 isoform 1
NM_001323895.2 NP_001310824.1 regulator of microtubule dynamics protein 3 isoform 2
NM_001323896.2 NP_001310825.1 regulator of microtubule dynamics protein 3 isoform 3
NM_001323897.2 NP_001310826.1 regulator of microtubule dynamics protein 3 isoform 3
NM_018145.3 NP_060615.1 regulator of microtubule dynamics protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
18070910 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18771726 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
22131369 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
22131369 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
29858488 GOA
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
18070910 GOA
located in organelle membrane contact site IDA
IDA: 通过直接分析推断
29858488 GOA
located in spindle microtubule IDA
IDA: 通过直接分析推断
18070910 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

regulator of microtubule dynamics protein 3

TCPTP-interacting protein 51

RMDN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RMDN3 Q96TC7 VAPA Homo sapiens Q9P0L0
Y2H
21900206
种属内
RMDN3 Q96TC7 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
种属内
RMDN3 Q96TC7 MOSPD2 Homo sapiens Q8NHP6
Confocal
29858488
种属内
RMDN3 Q96TC7 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
29858488
种属内
RMDN3 Q96TC7 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
种属内
RMDN3 Q96TC7 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
种属内
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
CoIP
15324660
种属内
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
PLA
21972092
种属内
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
Pull Down
18771726
种属内
RMDN3 Q96TC7 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
种属内
RMDN3 Q96TC7 VKORC1 Homo sapiens Q9BQB6
Validated Y2H
32296183
种属内
RMDN3 Q96TC7 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8

ALS8

Sclerosis, Lateral, Amyotrophic, Type Type 8
Amyotrophic Lateral Sclerosis 16, Juvenile

Amyotrophic Lateral Sclerosis Type 16

ALS16

Amyotrophic Lateral Sclerosis 16

Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Alzheimer Disease 7

Ad7

Alzheimer'S Disease 7

Alzheimer Disease, Familial, 7

Alzheimer Disease-7

Alzheimer Disease, Familial 7
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12013 RMDN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RMDN3 VGNC VGNC:64651
Macaca mulatta RMDN3 VGNC VGNC:76821
Rattus norvegicus RMDN3 RGD RGD:1308697
Bos taurus RMDN3 VGNC VGNC:33993
Mus musculus RMDN3 MGD MGI:1915059
Canis familiaris RMDN3 VGNC VGNC:45607
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