IRAK1 - interleukin 1 receptor associated kinase 1 Gene

中文名称：白介素 1 受体相关激酶 1

种属: Homo sapiens

同用名: IRAK; pelle

基因 ID: 3654 | 基因类型: protein coding

关于 IRAK1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,010,507-154,019,902 (from NCBI)

This gene has 14 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues.

功能概要

该基因编码白细胞介素 1 受体相关激酶 1，这是两种推定的丝氨酸/苏氨酸激酶之一，在刺激后与白细胞介素 1 受体 (IL1R) 相关。该基因部分负责 IL1 诱导的转录因子 NF-kappa B 的上调。已发现该基因编码不同亚型的选择性剪接转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

IRAK1 基因产物(7)

mRNA	Protein	Name
NM_001025243.2	NP_001020414.1	interleukin-1 receptor-associated kinase 1 isoform 3
NM_001410701.1	NP_001397630.1	interleukin-1 receptor-associated kinase 1 isoform 4
NM_001569.4	NP_001560.2	interleukin-1 receptor-associated kinase 1 isoform 1
XM_047442098.1	XP_047298054.1	interleukin-1 receptor-associated kinase 1 isoform X3
XM_005274668.5	XP_005274725.1	interleukin-1 receptor-associated kinase 1 isoform X1
NM_001025242.2	NP_001020413.1	interleukin-1 receptor-associated kinase 1 isoform 2
XM_047442097.1	XP_047298053.1	interleukin-1 receptor-associated kinase 1 isoform X2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11397809	GOA
enables kinase activity	IDA IDA: 通过直接分析推断	12054681	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10854325	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	10383454	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	10383454	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	12054681	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	33238146	GOA
enables protein serine/threonine kinase activity	EXP EXP: 通过实验结果推断	11960013	GOA
NOT enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11397809	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11397809	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	25515214	GOA
NOT involved in interleukin-1-mediated signaling pathway	IDA IDA: 通过直接分析推断	11397809	GOA
involved in interleukin-1-mediated signaling pathway	IMP IMP: 通过突变表型推断	10383454	GOA
involved in interleukin-33-mediated signaling pathway	IMP IMP: 通过突变表型推断	31435003	GOA
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	10383454	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	10383454	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	10383454	GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	22158417	GOA
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: 通过突变表型推断	25515214	GOA
involved in positive regulation of type I interferon production	IMP IMP: 通过突变表型推断	23633945	GOA
NOT involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	11397809	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: 通过直接分析推断	12054681	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	10383454	GOA
involved in regulation of cytokine-mediated signaling pathway	IMP IMP: 通过突变表型推断	10383454	GOA
involved in response to interleukin-1	IMP IMP: 通过突变表型推断	10383454	GOA
involved in response to lipopolysaccharide	IMP IMP: 通过突变表型推断	10383454	GOA
involved in toll-like receptor 2 signaling pathway	IMP IMP: 通过突变表型推断	10383454	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	23633945	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cell surface	IDA IDA: 通过直接分析推断	22851693	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	10854325	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRAK1 蛋白结构

Death

Pkinase

0
200
400
600
712 a.a.

蛋白主名

其他名称

interleukin-1 receptor-associated kinase 1

Pelle homolog

IRAK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	IRAK1	P51617	TRAF6	Homo sapiens	Q9Y4K3	CoIP	11518704
Intra	IRAK1	P51617	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	26752465
Intra	IRAK1	P51617	MYD88	Homo sapiens	Q99836	Anti Bait CoIP	26752465
Intra	IRAK1	P51617	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	17567694
Intra	IRAK1	P51617	PELI2	Homo sapiens	Q9HAT8	Pull Down	19081057
Intra	IRAK1	P51617	PELI3	Homo sapiens	Q8N2H9-2	Pull Down	19081057
Cross	IRAK1	P51617	Zc3h12a	Mus musculus	Q5D1E7	Protein Kinase Assay	22037600
Cross	IRAK1	P51617	Zc3h12a	Mus musculus	Q5D1E7	Anti Tag CoIP	22037600
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	Anti Bait CoIP	21743479
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	Pull Down	21743479
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	NMR	21743479
Intra	IRAK1	P51617	IRF4	Homo sapiens	Q15306	Anti Tag CoIP	21903422
Intra	IRAK1	P51617	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Fleck Retina, Familial Benign

FRFB	Familial Benign Flecked Retina
Familial Benign Fleck Retina

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type

Mecp2 Duplication Syndrome	Lubs X-Linked Mental Retardation Syndrome
MRXSL	Trisomy Xq28
Mental Retardation, X-Linked, With Recurrent Respiratory Infections	Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type
Mental Retardation, X-Linked, Lubs Type	Xlmr Syndrome, Lubs Type

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Syndromic X-Linked Intellectual Disability Lubs Type

Lubs X-Linked Mental Retardation Syndrome	Mecp2 Duplication Syndrome
Mental Retardation, X-Linked, Syndromic, Lubs Type	Mental Retardation, X-Linked, With Recurrent Respiratory Infections
Mrxsl	X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome
Mental Retardation, X-Linked Syndromic, Lubs Type

Gene Duplication Disease

Gene Duplication Syndrome

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Pediatric Systemic Lupus Erythematosus

Sle, Pediatric Onset

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Phototoxic Dermatitis

Dermatitis, Phototoxic	Photosensitisation Reaction
Photosensitive Dermatitis	Photosensitiveness

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy	Lymphoplasmacytic Lymphoma
Waldenstrom'S Macroglobulinaemia	Waldenstrom'S Syndrome
Waldenström Macroglobulinemia	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0039	Ginsenoside Rb1	Inhibitor	98.75%	否
HY-103017A	JH-X-119-01	Inhibitor	99.03%	否
HY-147141	HS-276	Inhibitor	98.59%	否
HY-103017	JH-X-119-01 hydrochloride	Inhibitor	98.15%	否
HY-111101	AZ1495	Inhibitor	98.07%	否
HY-153188	JNJ-1013	Degrader	99.80%	否
HY-134911	HS-243	Inhibitor	99.88%	否
HY-160487	KME-2780	Inhibitor	98.94%	否
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	否
HY-153224	GLPG2534	Inhibitor	98.73%	否
HY-153110	Larotinib	Inhibitor	99.50%	否
HY-N0039R	Ginsenoside Rb1 (Standard)	Inhibitor	/	否
HY-162641	AF-45	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IRAK1	MGD	MGI:107420
Canis familiaris	IRAK1	VGNC	VGNC:42087
Rattus norvegicus	IRAK1	RGD	RGD:1563841
Bos taurus	IRAK1	VGNC	VGNC:30264
Macaca mulatta	IRAK1	VGNC	VGNC:73757
Felis catus	IRAK1	VGNC	VGNC:67819
Others	IRAK1	NCBI

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