1. Gene
  2. IRF7 - interferon regulatory factor 7 Gene

IRF7 - interferon regulatory factor 7 Gene

中文名称:干扰素调节因子 7

种属: Homo sapiens

同用名: IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H

基因 ID: 3665 | 基因类型: protein coding

关于 IRF7

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:612,555-615,950 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 203 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues.

功能概要

该基因编码干扰素调节因子 7,是干扰素调节转录因子 (IRF) 家族的成员。它已被证明在病毒诱导细胞基因 (包括干扰素 β 链基因) 的转录激活中发挥作用。 IRF7 的诱导表达主要限于淋巴组织。编码的蛋白质在针对 DNA 和 RNA 病毒的先天免疫反应中起重要作用。[RefSeq 提供,2021 年 7 月]

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

IRF7 基因产物(3)

mRNA Protein Name
NM_001572.5 NP_001563.2 interferon regulatory factor 7 isoform a
NM_004029.4 NP_004020.1 interferon regulatory factor 7 isoform b
NM_004031.4 NP_004022.2 interferon regulatory factor 7 isoform d
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IMP
IMP: 通过突变表型推断
12374802 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
17404045 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17404045 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11943871 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
11473119 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
19176627 GOA
located in cytoplasm IGI
IGI: 通过遗传相互作用推断
23729669 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22065573 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IRF7 蛋白结构

IRF

IRF: Interferon regulatory factor transcription factor (11 - 126)

IRF-3

IRF-3: Interferon-regulatory factor 3 (288 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
蛋白主名 其他名称

interferon regulatory factor 7

interferon regulatory factor-7H

IRF7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IRF7 Q92985 LTN1 Homo sapiens O94822
Anti Tag CoIP
21903422
Intra IRF7 Q92985 TLK2 Homo sapiens Q86UE8
Anti Tag CoIP
21903422
Intra IRF7 Q92985 TRMT61B Homo sapiens Q9BVS5
Pull Down
30833792
Intra IRF7 Q92985 TRMT61B Homo sapiens Q9BVS5
Anti Tag CoIP
21903422
Intra IRF7 Q92985 TBK1 Homo sapiens Q9UHD2
Y2H
17599067
Intra IRF7 Q92985 IRAK1 Homo sapiens P51617
Anti Tag CoIP
21903422
Intra IRF7 Q92985 ARAF Homo sapiens P10398
Anti Tag CoIP
21903422
Intra IRF7 Q92985 PALD1 Homo sapiens Q9ULE6
Anti Tag CoIP
21903422
Intra IRF7 Q92985 AIP Homo sapiens O00170
Anti Tag CoIP
21903422
Intra IRF7 Q92985 CCDC47 Homo sapiens Q96A33
Anti Tag CoIP
21903422
Cross IRF7 Q92985 ORF45 Human herpesvirus 8 F5HDE4
Y2H
11943871
Cross IRF7 Q92985 ORF45 Human herpesvirus 8 F5HDE4
Pull Down
11943871
Cross IRF7 Q92985 P Measles virus Q77M19
Pull Down
18922877
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 39

IMD39

Immunodeficiency, Type 39

Predisposition To Severe Viral Infection Due To Irf7 Deficiency
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Vaccinia
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Rabies

Lyssa

Hydrophobia

St Hubert Disease

Lyme Disease

Lyme Borreliosis

Lyme Neuroborreliosis

Borreliosis

Borrelia Burgdorferi Infection

Neuroborreliosis

Bannwarth Syndrome

Bannworth'S Syndrome

Neurological Lyme Disease

B. Burgdorferi Infection

Borreliosis, Lyme

Infection By Borrelia Burgdorferi

Infection Due To Borrelia Burgdorferi Sensu Lato

Lym

Borrelia Infections

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma

Oral Hairy Leukoplakia

Hairy Leukoplakia

Leukoplakia, Hairy

Hairy Leucoplakia

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus IRF7 MGD MGI:1859212
Macaca mulatta IRF7 VGNC VGNC:73765
Felis catus IRF7 VGNC VGNC:67829
Rattus norvegicus IRF7 RGD RGD:1307828
Bos taurus IRF7 VGNC VGNC:30278