TRMT61B - tRNA methyltransferase 61B Gene

中文名称：tRNA 甲基转移酶 61B

种属: Homo sapiens

基因 ID: 55006 | 基因类型: protein coding

关于 TRMT61B

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,849,821-28,870,309 (from NCBI)

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues.

功能概要

启用 mRNA (腺嘌呤-N1-) -甲基转移酶活性； rRNA (腺嘌呤) 甲基转移酶活性；和 tRNA (腺嘌呤-N1-) -甲基转移酶活性。参与 mRNA 甲基化；线粒体 tRNA 甲基化；和蛋白质同源寡聚化。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

TRMT61B 基因产物(1)

mRNA	Protein	Name
NM_017910.4	NP_060380.3	tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA (adenine-N1-)-methyltransferase activity	IDA IDA: 通过直接分析推断	29107537	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA
enables rRNA (adenine) methyltransferase activity	IMP IMP: 通过突变表型推断	27631568	GOA
enables tRNA (adenine(58)-N1)-methyltransferase activity	IDA IDA: 通过直接分析推断	23097428	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA processing	IDA IDA: 通过直接分析推断	29107537	GOA
involved in mitochondrial tRNA processing	IDA IDA: 通过直接分析推断	23097428	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	27184847	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	23097428	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRMT61B 蛋白结构

GCD14

0
100
200
300
400
477 a.a.

蛋白主名

其他名称

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

mRNA methyladenosine-N(1)-methyltransferase

TRMT61B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRMT61B	Q9BVS5	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
种属内	TRMT61B	Q9BVS5	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
种属内	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Malignant Histiocytic Disease

Histiocytic Disorders, Malignant

3-Methylcrotonyl-Coa Carboxylase 1 Deficiency

MCC1D	Mccd Type 1
Mcc1 Deficiency	Methylcrotonylglycinuria Type I
3-Methylcrotonylglycinuria I	3-Methylcrotonoyl-Coa Carboxylase 1 Deficiency
3-Methylcrotonylglycinuria Type I	Mcgi
3 Methylcrotonyl-Coa Carboxylase 1 Deficiency	3-Methylcrotonyl Coa Carboxylase 1 Deficiency

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

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TRMT61B - tRNA methyltransferase 61B Gene

关于 TRMT61B

功能概要

TRMT61B 基因产物(1)

TRMT61B 蛋白结构

TRMT61B 蛋白互作信息

关联疾病

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TRMT61B - tRNA methyltransferase 61B Gene

关于 TRMT61B

功能概要

TRMT61B 基因产物(1)

TRMT61B 蛋白结构

TRMT61B 蛋白互作信息

关联疾病

相关产品

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z