LTN1 - listerin E3 ubiquitin protein ligase 1 Gene

中文名称：李斯特菌素 E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: RNF160; ZNF294; C21orf10; C21orf98

基因 ID: 26046 | 基因类型: protein coding

关于 LTN1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:28,928,144-28,992,877 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), placenta (RPKM 7.3) and 25 other tissues.

功能概要

与大多数 RING 指蛋白一样，LTN1 作为 E3 泛素连接酶发挥作用 (Chu 等人，2009 [PubMed 19196968]) 。[OMIM 提供，2010 年 11 月]

Like most RING finger proteins, LTN1 functions as an E3 ubiquitin Ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

LTN1 基因产物(2)

mRNA	Protein	Name
NM_001320766.2	NP_001307695.2	E3 ubiquitin-protein ligase listerin isoform 2
NM_015565.3	NP_056380.3	E3 ubiquitin-protein ligase listerin isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	25578875	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	25578875	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	25578875	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RQC complex	IDA IDA: 通过直接分析推断	25578875	GOA
located in cytosol	IDA IDA: 通过直接分析推断	25578875	GOA
is active in cytosolic ribosome	IDA IDA: 通过直接分析推断	25578875	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LTN1 蛋白结构

FANCL_C

0
300
600
900
1200
1500
1766 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase listerin

RING-type E3 ubiquitin transferase listerin

LTN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LTN1	O94822	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	21903422
种属内	LTN1	O94822	TIRAP	Homo sapiens	P58753	Anti Tag CoIP	21903422
种属内	LTN1	O94822	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07885	LTN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LTN1	MGD	MGI:1926163
Macaca mulatta	LTN1	VGNC	VGNC:74275
Canis familiaris	LTN1	VGNC	VGNC:42862
Bos taurus	LTN1	VGNC	VGNC:31078
Rattus norvegicus	LTN1	RGD	RGD:1311238
Felis catus	LTN1	VGNC	VGNC:63327

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LTN1 - listerin E3 ubiquitin protein ligase 1 Gene

关于 LTN1

功能概要

LTN1 基因产物(2)

LTN1 蛋白结构

LTN1 蛋白互作信息

关联疾病

直系同源

热门区域

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LTN1 - listerin E3 ubiquitin protein ligase 1 Gene

关于 LTN1

功能概要

LTN1 基因产物(2)

LTN1 蛋白结构

LTN1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z