2. Gene
  3. TLK2 - tousled like kinase 2 Gene

TLK2 - tousled like kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凌乱样激酶 2

种属: Homo sapiens

同用名: HsHPK; MRD57; PKU-ALPHA

基因 ID: 11011 | 基因类型: protein coding

关于 TLK2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,470,914-62,615,481 (from NCBI)

This gene has 32 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues.

功能概要

该基因编码的核丝氨酸/苏氨酸激酶最初是在拟南芥中发现的。编码的蛋白质被认为通过调节组蛋白 H3/H4 伴侣的水平在细胞周期 S 期染色质组装的调节中起作用。这种蛋白质与辐射引起的 DNA 损伤的双链断裂修复有关。该基因的假基因存在于 10 号和 17 号染色体上。交替剪接导致多个转录变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TLK2 基因产物(10)

mRNA Protein Name
NM_001284333.3 NP_001271262.1 serine/threonine-protein kinase tousled-like 2 isoform C
NM_001284363.1 NP_001271292.1 serine/threonine-protein kinase tousled-like 2 isoform B
NM_001330418.3 NP_001317347.1 serine/threonine-protein kinase tousled-like 2 isoform D
NM_001375269.1 NP_001362198.1 serine/threonine-protein kinase tousled-like 2 isoform E
NM_001375270.1 NP_001362199.1 serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375271.1 NP_001362200.1 serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375272.1 NP_001362201.1 serine/threonine-protein kinase tousled-like 2 isoform B
NM_001375273.1 NP_001362202.1 serine/threonine-protein kinase tousled-like 2 isoform D
NM_001411074.1 NP_001398003.1 serine/threonine-protein kinase tousled-like 2 isoform F
NM_006852.6 NP_006843.2 serine/threonine-protein kinase tousled-like 2 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12660173 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21903422 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12660173 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
12660173 GOA
involved in cellular response to gamma radiation IDA
IDA: 通过直接分析推断
12660173 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
20705056 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12660173 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
20016786 GOA
involved in nucleus localization IMP
IMP: 通过突变表型推断
29955062 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
20016786 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12660173 GOA
involved in regulation of chromatin organization IDA
IDA: 通过直接分析推断
12660173 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intermediate filament IDA
IDA: 通过直接分析推断
10455159 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9427565 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10455159 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TLK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (464 - 741)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase tousled-like 2

TLK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TLK2 Q86UE8 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra TLK2 Q86UE8 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 DYNLL1 Homo sapiens P63167
Pull Down
32707033
Intra TLK2 Q86UE8 TLK1 Homo sapiens Q9UKI8
Anti Tag CoIP
33961781
Intra TLK2 Q86UE8 DYNLL1 Homo sapiens P63167
Anti Tag CoIP
35271311
Intra TLK2 Q86UE8 TLK1 Homo sapiens Q9UKI8
Pull Down
32707033
Intra TLK2 Q86UE8 TLK1 Homo sapiens Q9UKI8
BioID
33323470
Intra TLK2 Q86UE8 DYNLL2 Homo sapiens Q96FJ2
BioID
33323470
Intra TLK2 Q86UE8 DYNLL1 Homo sapiens P63167
BioID
33323470
Intra TLK2 Q86UE8 DYNLL1 Homo sapiens P63167
Pull Down
33323470
Intra TLK2 Q86UE8 DYNLL2 Homo sapiens Q96FJ2
Pull Down
32707033
Intra TLK2 Q86UE8 TLK1 Homo sapiens Q9UKI8
Pull Down
33323470
Intra TLK2 Q86UE8 FRMD6 Homo sapiens Q96NE9-2
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 FRMD6 Homo sapiens Q96NE9-2
Validated Y2H
32296183
Intra TLK2 Q86UE8 FRMD6 Homo sapiens Q96NE9-2
Y2H Array
32296183
Intra TLK2 Q86UE8 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra TLK2 Q86UE8 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra TLK2 Q86UE8 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra TLK2 Q86UE8 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 SMARCC2 Homo sapiens Q8TAQ2
Anti Bait CoIP
36950384
Intra TLK2 Q86UE8 DMAP1 Homo sapiens Q9NPF5
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 DMAP1 Homo sapiens Q9NPF5
Validated Y2H
32296183
Intra TLK2 Q86UE8 DMAP1 Homo sapiens Q9NPF5
Y2H Array
32296183
Intra TLK2 Q86UE8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra TLK2 Q86UE8 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra TLK2 Q86UE8 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra TLK2 Q86UE8 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra TLK2 Q86UE8 ASF1A Homo sapiens Q9Y294
BioID
33323470
Intra TLK2 Q86UE8 ASF1A Homo sapiens Q9Y294
Pull Down
33323470
Intra TLK2 Q86UE8 IRF7 Homo sapiens Q92985
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 57

Mental Retardation, Autosomal Dominant 57

MRD57
Pica Disease

Pica
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162426 UNC-CA2-103 99.26% 否
HY-RS14571 TLK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TLK2 RGD RGD:1310907
Mus musculus TLK2 MGD MGI:1346023
Felis catus TLK2 VGNC VGNC:66212
Bos taurus TLK2 VGNC VGNC:35894
Macaca mulatta TLK2 VGNC VGNC:78368
Canis familiaris TLK2 VGNC VGNC:47399
Others TLK2 NCBI
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