DYNLL2 - dynein light chain LC8-type 2 Gene

中文名称：动力蛋白轻链 LC8-type 2

种属: Homo sapiens

同用名: Dlc2; DNCL1B; RSPH22

基因 ID: 140735 | 基因类型: protein coding

关于 DYNLL2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,083,419-58,095,542 (from NCBI)

This gene has 1 transcript (splice variant), 252 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues.

功能概要

预测启用动力蛋白中间链结合活性和动力蛋白轻中间链结合活性。预计参与纤毛组装。位于 9+0 非活动纤毛和中心体。活跃于谷氨酸能突触和突触后。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

DYNLL2 基因产物(1)

mRNA	Protein	Name
NM_080677.3	NP_542408.1	dynein light chain 2, cytoplasmic

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in 9+0 non-motile cilium	IDA IDA: 通过直接分析推断	29257953	GOA
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA
located in cytoskeleton	IDA IDA: 通过直接分析推断	20921139	GOA
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	22328512	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	22328512	GOA
is active in postsynapse	IDA IDA: 通过直接分析推断	22328512	GOA
is active in postsynapse	IMP IMP: 通过突变表型推断	22328512	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DYNLL2 蛋白结构

Dynein_light

0
89 a.a.

蛋白主名

其他名称

dynein light chain 2, cytoplasmic

8 kDa dynein light chain b

DYNLL2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DYNLL2	Q96FJ2	REDIC1	Homo sapiens	Q86WS4	Validated Y2H	25416956
种属内	DYNLL2	Q96FJ2	REDIC1	Homo sapiens	Q86WS4	Y2H Array	25416956
种属内	DYNLL2	Q96FJ2	RASGRP3	Homo sapiens	Q8IV61	Y2H Prey Pooling	25416956
种属内	DYNLL2	Q96FJ2	PKIG	Homo sapiens	Q9Y2B9	Validated Y2H	32296183
种属内	DYNLL2	Q96FJ2	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
种属内	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
种属内	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
种属内	DYNLL2	Q96FJ2	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
种属内	DYNLL2	Q96FJ2	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	35271311
种属内	DYNLL2	Q96FJ2	SECISBP2L	Homo sapiens	Q93073	Validated Y2H	25416956
种属内	DYNLL2	Q96FJ2	SECISBP2L	Homo sapiens	Q93073	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	DYNC1I1	Homo sapiens	O14576	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	35271311
种属内	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Y2H Prey Pooling	32296183
种属内	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32296183
种属内	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	FAM117B	Homo sapiens	Q6P1L5	TAP	27173435
种属内	DYNLL2	Q96FJ2	BMF	Homo sapiens	Q96LC9	Y2H Prey Pooling	25416956
种属内	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	TAP	27173435
种属内	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Anti Tag CoIP	35271311
种属内	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Y2H Pooling	16189514
种属内	DYNLL2	Q96FJ2	XIAP	Homo sapiens	P98170	Y2H Array	31515488
种属内	DYNLL2	Q96FJ2	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
种属内	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Y2H Prey Pooling	32296183
种属内	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
种属内	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Y2H Array	32296183
种属内	DYNLL2	Q96FJ2	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	35271311
种属内	DYNLL2	Q96FJ2	DNAL4	Homo sapiens	O96015	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	DNAL4	Homo sapiens	O96015	Y2H Array	31515488
种属内	DYNLL2	Q96FJ2	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
种属内	DYNLL2	Q96FJ2	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
种属内	DYNLL2	Q96FJ2	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	33961781
种属内	DYNLL2	Q96FJ2	MORN3	Homo sapiens	Q6PF18	Validated Y2H	25416956
种属间	DYNLL2	Q96FJ2	rex_htlv2	Human T-cell leukemia virus	Q85601	MAPPIT	22458338
种属间	DYNLL2	Q96FJ2	rex_htl1c	Human T-cell leukemia virus 1	P0C206	Y2H Pooling	22458338

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly

SRTD11

Bardet-Biedl Syndrome 7

BBS7	Bardet-Biedl Syndrome, Type 7

Louping Ill

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04089	DYNLL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DYNLL2	VGNC	VGNC:98902
Mus musculus	DYNLL2	MGD	MGI:1915347
Rattus norvegicus	DYNLL2	RGD	RGD:619860
Canis familiaris	DYNLL2	VGNC	VGNC:40151
Bos taurus	DYNLL2	VGNC	VGNC:28275

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4