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  2. PKIG - cAMP-dependent protein kinase inhibitor gamma Gene

PKIG - cAMP-dependent protein kinase inhibitor gamma Gene

中文名称:cAMP 依赖性蛋白激酶抑制因子γ

种属: Homo sapiens

同用名: PKI-gamma

基因 ID: 11142 | 基因类型: protein coding

关于 PKIG

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,531,875-44,619,037 (from NCBI)

This gene has 8 transcripts (splice variants), 173 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 51.1), urinary bladder (RPKM 28.8) and 24 other tissues.

功能概要

该基因编码蛋白激酶抑制剂家族的成员。对小鼠中类似蛋白质的研究表明,这种蛋白质可作为一种有效的竞争性 cAMP 依赖性蛋白激酶抑制剂,并且是各种组织中的主要抑制剂形式。编码的蛋白质可能参与成骨。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 7 月]

This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PKIG 基因产物(5)

mRNA Protein Name
NM_001281444.2 NP_001268373.1 cAMP-dependent protein kinase inhibitor gamma
NM_001281445.2 NP_001268374.1 cAMP-dependent protein kinase inhibitor gamma
NM_007066.5 NP_008997.1 cAMP-dependent protein kinase inhibitor gamma
NM_181804.3 NP_861520.1 cAMP-dependent protein kinase inhibitor gamma
NM_181805.3 NP_861521.1 cAMP-dependent protein kinase inhibitor gamma
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PKIG 蛋白结构

PKI

PKI: cAMP-dependent protein kinase inhibitor (2 - 71)

  • 0
  • 76 a.a.
蛋白主名 其他名称

cAMP-dependent protein kinase inhibitor gamma

protein kinase (cAMP-dependent, catalytic) inhibitor gamma

PKIG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PKIG Q9Y2B9 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
种属内
PKIG Q9Y2B9 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
种属内
PKIG Q9Y2B9 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
32296183
种属内
PKIG Q9Y2B9 DYNLL2 Homo sapiens Q96FJ2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Theileriasis

Theileriosis

Infection By Theileria

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PKIG RGD RGD:628775
Bos taurus PKIG VGNC VGNC:32942
Macaca mulatta PKIG VGNC VGNC:97118
Mus musculus PKIG MGD MGI:1343086