2. Gene
  3. RASGRP3 - RAS guanyl releasing protein 3 Gene

RASGRP3 - RAS guanyl releasing protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAS 鸟苷释放蛋白 3

种属: Homo sapiens

同用名: GRP3

基因 ID: 25780 | 基因类型: protein coding

关于 RASGRP3

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:33,436,348-33,564,731 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 24 paralogues. Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues.

功能概要

该基因编码的蛋白质是一种鸟嘌呤核苷酸交换因子，可激活致癌基因 HRAS 和 RAP1A。该基因的缺陷与系统性红斑狼疮和多种癌症有关。[RefSeq 提供，2017 年 3 月]

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]

RASGRP3 基因产物(10)

mRNA Protein Name
NM_001139488.2 NP_001132960.1 ras guanyl-releasing protein 3 isoform 1
NM_001349975.2 NP_001336904.1 ras guanyl-releasing protein 3 isoform 1
NM_001349976.2 NP_001336905.1 ras guanyl-releasing protein 3 isoform 1
NM_001349977.2 NP_001336906.1 ras guanyl-releasing protein 3 isoform 1
NM_001349978.2 NP_001336907.1 ras guanyl-releasing protein 3 isoform 2
NM_001349979.2 NP_001336908.1 ras guanyl-releasing protein 3 isoform 2
NM_001349980.2 NP_001336909.1 ras guanyl-releasing protein 3 isoform 2
NM_001349981.2 NP_001336910.1 ras guanyl-releasing protein 3 isoform 2
NM_015376.3 NP_056191.1 ras guanyl-releasing protein 3 isoform 2
NM_170672.3 NP_733772.1 ras guanyl-releasing protein 3 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
10934204 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RASGRP3 蛋白结构

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (8 - 102)

RasGEF

RasGEF: RasGEF domain (151 - 331)

EF-hand_6

EF-hand_6: EF-hand domain (426 - 448)

EF-hand_5

EF-hand_5: EF hand (460 - 476)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (495 - 544)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
蛋白主名 其他名称

ras guanyl-releasing protein 3

CalDAG-GEFIII

RASGRP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra RASGRP3 Q8IV61 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra RASGRP3 Q8IV61 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra RASGRP3 Q8IV61 DYNLL2 Homo sapiens Q96FJ2
Validated Y2H
25416956
Intra RASGRP3 Q8IV61 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11695 RASGRP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-123977 RasGRP3 ligand 1 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RASGRP3 VGNC VGNC:33749
Canis familiaris RASGRP3 VGNC VGNC:45373
Rattus norvegicus RASGRP3 RGD RGD:1304612
Felis catus RASGRP3 VGNC VGNC:64502
Macaca mulatta RASGRP3 VGNC VGNC:106206
Mus musculus RASGRP3 MGD MGI:3028579
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z