HMBOX1 - homeobox containing 1 Gene

中文名称：含同源盒 1

种属: Homo sapiens

同用名: HOT1; TAH1; PBHNF; HNF1LA

基因 ID: 79618 | 基因类型: protein coding

关于 HMBOX1

Cytogenetic location: 8p21.1-p12 Genomic coordinates (GRCh38): 8:28,890,116-29,053,270 (from NCBI)

This gene has 16 transcripts (splice variants) and 279 orthologues. Ubiquitous expression in adrenal (RPKM 3.8), testis (RPKM 3.5) and 25 other tissues.

功能概要

启用双链端粒 DNA 结合活性；相同的蛋白质结合活性；和序列特异性双链 DNA 结合活性。参与 RNA 聚合酶 II 对转录的负调控；端粒酶活性的正调节；以及通过端粒酶对端粒维持的正调节。位于几个细胞成分中，包括中心体；染色体，端粒区；和核体。 [由基因组资源联盟提供，2022 年 4 月]

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of Telomerase activity; and positive regulation of telomere maintenance via Telomerase. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

HMBOX1 基因产物(17)

mRNA	Protein	Name
NM_001135726.3	NP_001129198.1	homeobox-containing protein 1 isoform 1
NM_001324382.2	NP_001311311.1	homeobox-containing protein 1 isoform 1
NM_001324383.2	NP_001311312.1	homeobox-containing protein 1 isoform 2
NM_001324384.1	NP_001311313.1	homeobox-containing protein 1 isoform 2
NM_001324385.2	NP_001311314.1	homeobox-containing protein 1 isoform 3
NM_001324386.2	NP_001311315.1	homeobox-containing protein 1 isoform 4
NM_001324387.2	NP_001311316.1	homeobox-containing protein 1 isoform 5
NM_001324388.2	NP_001311317.1	homeobox-containing protein 1 isoform 5
NM_001324389.2	NP_001311318.1	homeobox-containing protein 1 isoform 6
NM_001324390.1	NP_001311319.1	homeobox-containing protein 1 isoform 6
NM_001324391.2	NP_001311320.1	homeobox-containing protein 1 isoform 7
NM_001324392.1	NP_001311321.1	homeobox-containing protein 1 isoform 7
NM_001324393.2	NP_001311322.1	homeobox-containing protein 1 isoform 8
NM_001324394.2	NP_001311323.1	homeobox-containing protein 1 isoform 8
NM_001324395.2	NP_001311324.1	homeobox-containing protein 1 isoform 9
NM_001330498.2	NP_001317427.1	homeobox-containing protein 1 isoform 10
NM_024567.4	NP_078843.2	homeobox-containing protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables double-stranded telomeric DNA binding	IDA IDA: 通过直接分析推断	23685356	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23685356	GOA
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	23685356	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables telomeric DNA binding	IDA IDA: 通过直接分析推断	23685356	GOA
enables telomeric DNA binding	IMP IMP: 通过突变表型推断	23685356	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	19757162	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21839858	GOA
involved in telomere maintenance via telomerase	IDA IDA: 通过直接分析推断	23685356	GOA
involved in telomere-telomerase complex assembly	IDA IDA: 通过直接分析推断	23685356	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	23685356	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19757162	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19757162	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HMBOX1 蛋白结构

HNF-1_N

Homeobox

0
100
200
300
420 a.a.

蛋白主名

其他名称

homeobox-containing protein 1

homeobox telomere-binding protein 1

HMBOX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HMBOX1	Q6NT76	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	FAM74A4	Homo sapiens	Q5TZK3	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	FAM74A4	Homo sapiens	Q5TZK3	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	AEBP2	Homo sapiens	Q6ZN18-2	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	AEBP2	Homo sapiens	Q6ZN18-2	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	AEBP2	Homo sapiens	Q6ZN18-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	POLDIP3	Homo sapiens	Q8WUT1	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	MFAP1	Homo sapiens	P55081	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	SNRPB2	Homo sapiens	P08579	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	SNRPB2	Homo sapiens	P08579	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	PRKAA1	Homo sapiens	Q13131	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	FGF11	Homo sapiens	Q92914	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ASB7	Homo sapiens	Q9H672-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ASB7	Homo sapiens	Q9H672-2	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	ASB7	Homo sapiens	Q9H672-2	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	PRKAA2	Homo sapiens	P54646	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	ZMYM5	Homo sapiens	Q9UJ78-2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	GSC2	Homo sapiens	O15499	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	SAP30L	Homo sapiens	Q9HAJ7	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	SAP30L	Homo sapiens	Q9HAJ7	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	FARS2	Homo sapiens	O95363	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	FARS2	Homo sapiens	O95363	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	FARS2	Homo sapiens	O95363	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	31515488
种属内	HMBOX1	Q6NT76	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	DNTTIP1	Homo sapiens	Q9H147	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	DNTTIP1	Homo sapiens	Q9H147	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	DNTTIP1	Homo sapiens	Q9H147	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	23685356
种属内	HMBOX1	Q6NT76	ATP5PO	Homo sapiens	P48047	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	RPL9	Homo sapiens	P32969	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	RPL9	Homo sapiens	P32969	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	CCNG1	Homo sapiens	P51959	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	CCNG1	Homo sapiens	P51959	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	ASB7	Homo sapiens	Q9H672	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	KAT5	Homo sapiens	Q92993	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	KAT5	Homo sapiens	Q92993	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	KAT5	Homo sapiens	Q92993	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	VPS72	Homo sapiens	Q15906	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	VPS72	Homo sapiens	Q15906	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	MAGEH1	Homo sapiens	Q9H213	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	UBA6	Homo sapiens	A0AVT1	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	MRPL11	Homo sapiens	Q9Y3B7	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	DKC1	Homo sapiens	O60832	Anti Bait CoIP	23685356
种属内	HMBOX1	Q6NT76	ZNF337	Homo sapiens	Q9Y3M9	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZNF337	Homo sapiens	Q9Y3M9	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	ZNF337	Homo sapiens	Q9Y3M9	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	C8orf33	Homo sapiens	Q9H7E9	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	C8orf33	Homo sapiens	Q9H7E9	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	FAM161A	Homo sapiens	Q3B820	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	UBE2Z	Homo sapiens	Q9H832	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	UBE2Z	Homo sapiens	Q9H832	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	FNDC11	Homo sapiens	Q9BVV2	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	FNDC11	Homo sapiens	Q9BVV2	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	GNL3L	Homo sapiens	Q9NVN8	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	PAX6	Homo sapiens	P26367	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	IPO13	Homo sapiens	O94829	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	IPO13	Homo sapiens	O94829	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	REEP6	Homo sapiens	Q96HR9	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	FAM13C	Homo sapiens	Q8NE31	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	FAM13C	Homo sapiens	Q8NE31	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	DAB1	Homo sapiens	O75553	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	DAB1	Homo sapiens	O75553	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	HMBOX1	Q6NT76	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ABITRAM	Homo sapiens	Q9NX38	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	ABITRAM	Homo sapiens	Q9NX38	Validated Y2H	32296183
种属内	HMBOX1	Q6NT76	ABITRAM	Homo sapiens	Q9NX38	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	PIP4K2B	Homo sapiens	P78356	Validated Y2H	25416956
种属内	HMBOX1	Q6NT76	PIP4K2B	Homo sapiens	P78356	Y2H Prey Pooling	25416956
种属内	HMBOX1	Q6NT76	PIP4K2B	Homo sapiens	P78356	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	TCEANC	Homo sapiens	Q8N8B7	Y2H Array	25416956
种属内	HMBOX1	Q6NT76	CDCA8	Homo sapiens	Q53HL2	Y2H Prey Pooling	32296183
种属内	HMBOX1	Q6NT76	CDCA8	Homo sapiens	Q53HL2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06223	HMBOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HMBOX1	VGNC	VGNC:62823
Macaca mulatta	HMBOX1	VGNC	VGNC:73443
Rattus norvegicus	HMBOX1	RGD	RGD:1306787
Canis familiaris	HMBOX1	VGNC	VGNC:41703
Bos taurus	HMBOX1	VGNC	VGNC:29869
Mus musculus	HMBOX1	MGD	MGI:2445066

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