2. Gene
  3. GNL3L - G protein nucleolar 3 like Gene

GNL3L - G protein nucleolar 3 like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白核仁 3 样

种属: Homo sapiens

同用名: GNL3B

基因 ID: 54552 | 基因类型: protein coding

关于 GNL3L

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:54,530,219-54,645,854 (from NCBI)

This gene has 12 transcripts (splice variants), 188 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 3.6), appendix (RPKM 3.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质似乎是一种核仁 GTP 酶，它对核糖体 pre-rRNA 加工和细胞增殖至关重要。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GNL3L 基因产物(2)

mRNA Protein Name
NM_001184819.2 NP_001171748.1 guanine nucleotide-binding protein-like 3-like protein
NM_019067.6 NP_061940.1 guanine nucleotide-binding protein-like 3-like protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
19487455 GOA
involved in negative regulation of protein sumoylation IMP
IMP: 通过突变表型推断
22641345 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
19487455 GOA
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
18082603 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IDA
IDA: 通过直接分析推断
19487455 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IMP
IMP: 通过突变表型推断
19487455 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: 通过突变表型推断
19487455 GOA
involved in regulation of protein stability IDA
IDA: 通过直接分析推断
19487455 GOA
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
19487455 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
18082603 GOA
part of telomerase holoenzyme complex IDA
IDA: 通过直接分析推断
18082603 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNL3L 蛋白结构

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (254 - 315)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
蛋白主名 其他名称

guanine nucleotide-binding protein-like 3-like protein

G protein nucleolar 3B

GNL3L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra GNL3L Q9NVN8 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
31515488
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
25416956
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
25416956
Intra GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra GNL3L Q9NVN8 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra GNL3L Q9NVN8 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra GNL3L Q9NVN8 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra GNL3L Q9NVN8 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra GNL3L Q9NVN8 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Anti Bait CoIP
21132010
Intra GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Anti Tag CoIP
21132010
Intra GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Confocal
21132010
Intra GNL3L Q9NVN8 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra GNL3L Q9NVN8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra GNL3L Q9NVN8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05567 GNL3L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GNL3L VGNC VGNC:41328
Mus musculus GNL3L MGD MGI:2448557
Felis catus GNL3L VGNC VGNC:62627
Rattus norvegicus GNL3L RGD RGD:1600217
Macaca mulatta GNL3L VGNC VGNC:73011
Bos taurus GNL3L VGNC VGNC:29474
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