2. Gene
  3. ATP5PO - ATP synthase peripheral stalk subunit OSCP Gene

ATP5PO - ATP synthase peripheral stalk subunit OSCP Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATP 合成酶外周茎亚基 OSCP

种属: Homo sapiens

同用名: ATPO; OSCP; ATP5O; HMC08D05

基因 ID: 539 | 基因类型: protein coding

关于 ATP5PO

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,903,453-33,915,804 (from NCBI)

This gene has 11 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in heart (RPKM 296.0), duodenum (RPKM 137.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是在线粒体基质中发现的 F 型 ATP 酶的一个组成部分。 F 型 ATP 酶由催化核心和膜质子通道组成。编码的蛋白质似乎是连接这两个组件的连接器的一部分，并且可能参与构象变化或质子电导的传递。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

ATP5PO 基因产物(1)

mRNA Protein Name
NM_001697.3 NP_001688.1 ATP synthase subunit O, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: 通过直接分析推断
12110673 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proton motive force-driven mitochondrial ATP synthesis IMP
IMP: 通过突变表型推断
15850986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
12110673 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17851741 GOA
part of proton-transporting ATP synthase complex IDA
IDA: 通过直接分析推断
12110673 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATP5PO 蛋白结构

OSCP

OSCP: ATP synthase delta (OSCP) subunit (37 - 209)

  • 0
  • 100
  • 200
  • 213 a.a.
蛋白主名 其他名称

ATP synthase subunit O, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

ATP5PO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ATP5PO P48047 CCDC136 Homo sapiens Q96JN2-2
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 CCDC136 Homo sapiens Q96JN2-2
Validated Y2H
25416956
Intra ATP5PO P48047 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Y2H Prey Pooling
32296183
Intra ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Validated Y2H
32296183
Intra ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Y2H Array
32296183
Intra ATP5PO P48047 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra ATP5PO P48047 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra ATP5PO P48047 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra ATP5PO P48047 NDC80 Homo sapiens O14777
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 NDC80 Homo sapiens O14777
Y2H Array
25416956
Intra ATP5PO P48047 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra ATP5PO P48047 PPID Homo sapiens Q08752
Pull Down
30266287
Intra ATP5PO P48047 PPID Homo sapiens Q08752
Anti Bait CoIP
30266287
Intra ATP5PO P48047 KRT15 Homo sapiens P19012
Validated Y2H
25416956
Intra ATP5PO P48047 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra ATP5PO P48047 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra ATP5PO P48047 NT5C2 Homo sapiens P49902
Y2H Prey Pooling
25416956
Intra ATP5PO P48047 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra ATP5PO P48047 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
Pull Down
30266287
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leigh Syndrome

Leigh Disease

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

LS

Sne

Leigh'S Disease

Leigh Syndrome Due To Mitochondrial Complex I Deficiency

Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

Subacute Necrotizing Encephalomyelopathy

Necrotizing Encephalopathy Infantile Subacute Of Leigh

Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

Infantile Necrotizing Encephalomyelopathy

Juvenile Subacute Necrotizing Encephalomyelopathy

Leigh'S Necrotizing Encephalopathy

Subacute Necrotizing Encephalopathy

Juvenile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

Leigh Syndrome Due To Mitochondrial Complex V Deficiency

Encephalopathy, Subacute Necrotizing, Infantile

Encephalopathy, Subacute Necrotizing, Juvenile

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalomyelopathy

Subacute Necrotising Encephalopathy
Graves' Disease

Graves Disease

Exophthalmic Goiter

Basedow'S Disease

Grave'S Disease

Basedow Disease

Toxic Diffuse Goiter

Graves' Hyperthyroidism

Parry Disease

Autoimmune Hyperthyroidism

Toxic Multinodular Goiter
Hashimoto Thyroiditis

Autoimmune Thyroiditis

Hashimoto Struma

Hashimoto'S Thyroiditis

Chronic Lymphocytic Thyroiditis

Lymphocytic Thyroiditis

Hashimoto Disease

Ht

Hashimoto'S Disease

Hashimoto'S Syndrome

Hypothyroidism, Autoimmune

Autoimmune Chronic Lymphocytic Thyroiditis

Chronic Lymphocytic Thyroiditides

Hashimoto Syndrome

Hashimotos Thyroiditis

Hashimoto Thyroiditis, Susceptibility To

Thyroiditis, Autoimmune

Lymphomatous Thyroiditis

Lymphoid Thyroiditis

Chronic Lymphadenoid Thyroiditis

Autoimmune Lymphocytic Chronic Thyroiditis

Goitre Lymphomatosa

Hashitoxicosis

Hashimoto Hypothyroidism

Lymphadenoid Goitre

Struma Lymphomatosa

Hyperthyroidism With Hashimoto Disease

Hashimoto Thyrotoxicosis

Thyrotoxicosis Due To Hashimoto Thyroiditis

Struma Lymphomatosis

Lymphadenoid Struma
Goiter

Goitre
Hypotropia
Subacute Thyroiditis

Giant-Cell Thyroiditis

Granulomatous Thyroiditis

Subacute Granulomatous Thyroiditis

De Quervain'S Thyroiditis

Thyroiditis Subacute

Thyroiditis, Subacute

Pseudogranulomatous Thyroiditis

De Quervain Thyroiditis

Nonsuppurative Subacute Thyroiditis

Pseudotuberculous Thyroiditis

Nonsuppurative Thyroiditis Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01213 ATP5PO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATP5PO MGD MGI:106341
Rattus norvegicus ATP5PO RGD RGD:621379
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