2. Gene
  3. NDC80 - NDC80 kinetochore complex component Gene

NDC80 - NDC80 kinetochore complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NDC80 着丝粒复合体成分

种属: Homo sapiens

同用名: HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

基因 ID: 10403 | 基因类型: protein coding

关于 NDC80

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,571,557-2,616,635 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Broad expression in testis (RPKM 8.6), lymph node (RPKM 8.5) and 16 other tissues.

功能概要

该基因编码 NDC80 着丝粒复合体的一个成分。编码的蛋白质由一个 N 端微管结合结构域和一个与复合物其他成分相互作用的 C 端卷曲结构域组成。这种蛋白质的功能是组织和稳定微管-着丝粒相互作用，并且是正确的染色体分离所必需的。[RefSeq 提供，2011 年 10 月]

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

NDC80 基因产物(1)

mRNA Protein Name
NM_006101.3 NP_006092.1 kinetochore protein NDC80 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20360068 GOA
enables kinetochore adaptor activity IDA
IDA: 通过直接分析推断
30409912 GOA
enables microtubule binding IMP
IMP: 通过突变表型推断
18455984 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14699129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
30409912 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
22581055 GOA
involved in attachment of spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
18455984 GOA
involved in attachment of spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
19468067 GOA
acts upstream of or within centrosome duplication IDA
IDA: 通过直接分析推断
18940925 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
14699129 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: 通过突变表型推断
19468067 GOA
acts upstream of or within metaphase chromosome alignment IDA
IDA: 通过直接分析推断
18940925 GOA
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
25743205 GOA
involved in mitotic spindle organization IMP
IMP: 通过突变表型推断
14699129 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: 通过突变表型推断
25743205 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ndc80 complex IDA
IDA: 通过直接分析推断
14699129 GOA
part of Ndc80 complex IPI
IPI: 通过物理相互作用推断
18455984 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
14699129 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
18195732 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDC80 蛋白结构

Ndc80_HEC

Ndc80_HEC: HEC/Ndc80p family (50 - 207)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
蛋白主名 其他名称

kinetochore protein NDC80 homolog

NDC80 homolog, kinetochore complex component

关联疾病

疾病名称 别名
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma

Endometrial Adenoacanthoma

Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

Adenocarcinoma Of Endometrium

Adenocarcinoma Of The Endometrium

Adenocarcinoma Of Uterus

Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

Endometrioid Adenoma Or Carcinoma

Endometrioid Adenomas And Carcinomas

Endometrioid Carcinoma Of Endometrium

Endometrium Adenocarcinoma
Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1

Autosomal Dominant Non-Syndromic Intellectual Disability 1

Mental Retardation, Autosomal Dominant 1

Autosomal Dominant Intellectual Developmental Disorder 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09105 NDC80 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NDC80 MGD MGI:1914302
Canis familiaris NDC80 VGNC VGNC:43670
Rattus norvegicus NDC80 RGD RGD:1310154
Bos taurus NDC80 VGNC VGNC:31931
Felis catus NDC80 VGNC VGNC:63747
Macaca mulatta NDC80 VGNC VGNC:74975
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