2. Gene
  3. NDC80 - NDC80 kinetochore complex component Gene

NDC80 - NDC80 kinetochore complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NDC80 着丝粒复合体成分

种属: Homo sapiens

同用名: HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

基因 ID: 10403 | 基因类型: protein coding

关于 NDC80

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,571,557-2,616,635 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Broad expression in testis (RPKM 8.6), lymph node (RPKM 8.5) and 16 other tissues.

功能概要

该基因编码 NDC80 着丝粒复合体的一个成分。编码的蛋白质由一个 N 端微管结合结构域和一个与复合物其他成分相互作用的 C 端卷曲结构域组成。这种蛋白质的功能是组织和稳定微管-着丝粒相互作用，并且是正确的染色体分离所必需的。[RefSeq 提供，2011 年 10 月]

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with Other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

NDC80 基因产物(1)

mRNA Protein Name
NM_006101.3 NP_006092.1 kinetochore protein NDC80 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20360068 GOA
enables kinetochore adaptor activity IDA
IDA: 通过直接分析推断
30409912 GOA
enables microtubule binding IMP
IMP: 通过突变表型推断
18455984 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14699129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
30409912 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
22581055 GOA
involved in attachment of spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
18455984 GOA
involved in attachment of spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
19468067 GOA
acts upstream of or within centrosome duplication IDA
IDA: 通过直接分析推断
18940925 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
14699129 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: 通过突变表型推断
19468067 GOA
acts upstream of or within metaphase chromosome alignment IDA
IDA: 通过直接分析推断
18940925 GOA
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
25743205 GOA
involved in mitotic spindle organization IMP
IMP: 通过突变表型推断
14699129 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: 通过突变表型推断
25743205 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ndc80 complex IDA
IDA: 通过直接分析推断
14699129 GOA
part of Ndc80 complex IPI
IPI: 通过物理相互作用推断
18455984 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
14699129 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
18195732 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDC80 蛋白结构

Ndc80_HEC

Ndc80_HEC: HEC/Ndc80p family (50 - 207)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
蛋白主名 其他名称

kinetochore protein NDC80 homolog

NDC80 homolog, kinetochore complex component

NDC80 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NDC80 O14777 ZWINT Homo sapiens O95229
IF
16732327
种属内
NDC80 O14777 ZWINT Homo sapiens O95229
Y2H
16732327
种属内
NDC80 O14777 ZWINT Homo sapiens O95229
Pull Down
16732327
种属内
NDC80 O14777 ZWINT Homo sapiens O95229
Anti Bait CoIP
16732327
种属内
NDC80 O14777 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
种属内
NDC80 O14777 CENPH Homo sapiens Q9H3R5
Y2H
15713649
种属内
NDC80 O14777 TP53BP2 Homo sapiens Q13625-3
Validated Y2H
25416956
种属内
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
种属内
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
种属内
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
种属内
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Validated Y2H
32296183
种属内
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Array
32296183
种属内
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
种属内
NDC80 O14777 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 SFR1 Homo sapiens Q86XK3
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 SFR1 Homo sapiens Q86XK3
Y2H Array
25416956
种属内
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
种属内
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
种属内
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
种属内
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
种属内
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
种属内
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
种属内
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
种属内
NDC80 O14777 CAGE1 Homo sapiens Q8TC20-4
Validated Y2H
32296183
种属内
NDC80 O14777 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
种属内
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Validated Y2H
32296183
种属内
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Y2H Array
32296183
种属内
NDC80 O14777 HIP1R Homo sapiens O75146-2
Validated Y2H
32296183
种属内
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
种属内
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
种属内
NDC80 O14777 KLC3 Homo sapiens Q6P597
Y2H Array
25416956
种属内
NDC80 O14777 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
种属内
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
32296183
种属内
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Y2H Array
32296183
种属内
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
种属内
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
种属内
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Y2H Array
32296183
种属内
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Validated Y2H
32296183
种属内
NDC80 O14777 KRT75 Homo sapiens O95678
Validated Y2H
32296183
种属内
NDC80 O14777 KRT75 Homo sapiens O95678
Y2H Array
32296183
种属内
NDC80 O14777 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
种属内
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
种属内
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Validated Y2H
32296183
种属内
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
25416956
种属内
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Array
30886144
种属内
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Array
31515488
种属内
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 MED4 Homo sapiens Q9NPJ6
Validated Y2H
25416956
种属内
NDC80 O14777 ATF4 Homo sapiens P18848
Validated Y2H
32296183
种属内
NDC80 O14777 ATF4 Homo sapiens P18848
Y2H Array
32296183
种属内
NDC80 O14777 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
种属内
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
种属内
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
种属内
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25416956
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
种属内
NDC80 O14777 STX11 Homo sapiens O75558
Y2H Array
25416956
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Anti Tag CoIP
25416956
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
GMS
17129783
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
GMS
15961401
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Anti Bait CoIP
14699129
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
TAP
24981860
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Pull Down
15961401
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Density Sedimentation
15961401
种属内
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
TAP
20360068
种属内
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Y2H Prey Pooling
32296183
种属内
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Validated Y2H
32296183
种属内
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Y2H Array
32296183
种属内
NDC80 O14777 CCNK Homo sapiens O75909
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 CCNK Homo sapiens O75909
Y2H Array
25416956
种属内
NDC80 O14777 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
NDC80 O14777 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
种属内
NDC80 O14777 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
种属内
NDC80 O14777 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 HGS Homo sapiens O14964
Validated Y2H
32296183
种属内
NDC80 O14777 KRT6B Homo sapiens P04259
Validated Y2H
25416956
种属内
NDC80 O14777 KRT6B Homo sapiens P04259
Y2H Array
25416956
种属内
NDC80 O14777 CCNH Homo sapiens P51946
Validated Y2H
25416956
种属内
NDC80 O14777 CCNH Homo sapiens P51946
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 CCNH Homo sapiens P51946
Y2H Array
25416956
种属内
NDC80 O14777 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
种属内
NDC80 O14777 SGF29 Homo sapiens Q96ES7
Validated Y2H
25416956
种属内
NDC80 O14777 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
种属内
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Y2H Array
25416956
种属内
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
种属内
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 AMOTL2 Homo sapiens Q9Y2J4
Y2H Pooling
16189514
种属内
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Anti Tag CoIP
33961781
种属内
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Pooling
16189514
种属内
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
25416956
种属内
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
种属内
NDC80 O14777 NDEL1 Homo sapiens Q9GZM8
Y2H Array
25416956
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
GMS
15961401
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
TAP
20360068
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Anti Tag CoIP
14699129
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
MAPPIT
25416956
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Density Sedimentation
15961401
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Anti Bait CoIP
14699129
种属内
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
TAP
24981860
种属间: 跨种属相互作用 种属内: 同种属相互作用

NDC80 抗体

目录号 产品名 应用 反应物种
HY-P83594 HEC1 Antibody (YA3339) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma

Endometrial Adenoacanthoma

Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

Adenocarcinoma Of Endometrium

Adenocarcinoma Of The Endometrium

Adenocarcinoma Of Uterus

Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

Endometrioid Adenoma Or Carcinoma

Endometrioid Adenomas And Carcinomas

Endometrioid Carcinoma Of Endometrium

Endometrium Adenocarcinoma
Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1

Autosomal Dominant Non-Syndromic Intellectual Disability 1

Mental Retardation, Autosomal Dominant 1

Autosomal Dominant Intellectual Developmental Disorder 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09105 NDC80 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NDC80 MGD MGI:1914302
Canis familiaris NDC80 VGNC VGNC:43670
Rattus norvegicus NDC80 RGD RGD:1310154
Bos taurus NDC80 VGNC VGNC:31931
Felis catus NDC80 VGNC VGNC:63747
Macaca mulatta NDC80 VGNC VGNC:74975
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