1. Gene
  2. SPC25 - SPC25 component of NDC80 kinetochore complex Gene

SPC25 - SPC25 component of NDC80 kinetochore complex Gene

中文名称:NDC80 着丝粒复合体的 SPC25 成分

种属: Homo sapiens

同用名: AD024; SPBC25; hSpc25

基因 ID: 57405 | 基因类型: protein coding

关于 SPC25

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,861,521-168,890,430 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 199 orthologues. Broad expression in lymph node (RPKM 4.1), bone marrow (RPKM 2.8) and 19 other tissues.

功能概要

该基因编码的蛋白质可能参与着丝粒-微管相互作用和纺锤体检查点活动。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

SPC25 基因产物(1)

mRNA Protein Name
NM_020675.4 NP_065726.1 kinetochore protein Spc25
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14699129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
18455984 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
14699129 GOA
involved in mitotic spindle organization IMP
IMP: 通过突变表型推断
14699129 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ndc80 complex IDA
IDA: 通过直接分析推断
14699129 GOA
part of Ndc80 complex IPI
IPI: 通过物理相互作用推断
18455984 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
14699129 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
24530301 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPC25 蛋白结构

Spindle_Spc25

Spindle_Spc25: Chromosome segregation protein Spc25 (146 - 220)

  • 0
  • 100
  • 200
  • 224 a.a.
蛋白主名 其他名称

kinetochore protein Spc25

2600017H08Rik

关联疾病

疾病名称 别名
Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal

Ankylosing Vertebral Hyperostosis

Dish

Disseminated Idiopathic Skeletal Hyperostosis

Forestier Disease

Forestier'S Disease

Hyperostosis Diffuse Idiopathic Skeletal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SPC25 RGD RGD:1307811
Felis catus SPC25 VGNC VGNC:65625
Bos taurus SPC25 VGNC VGNC:35196
Mus musculus SPC25 MGD MGI:1913692
Canis familiaris SPC25 VGNC VGNC:46724
Macaca mulatta SPC25 VGNC VGNC:104556