CENPH - centromere protein H Gene

中文名称：着丝粒蛋白 H

种属: Homo sapiens

关于 CENPH

功能概要

着丝粒和着丝粒蛋白在着丝粒结构、着丝粒形成和姐妹染色单体分离中起着关键作用。由该基因编码的蛋白质在间期和中期与内着丝粒板蛋白 CENP-A 和 CENP-C 共定位。它位于着丝粒异染色质之外，CENP-B 位于此处，以及着丝粒冠内，CENP-E 在前中期位于此处。人们认为这种蛋白质可以与自身结合，也可以与 CENP-A、CENP-B 或 CENP-C 结合。蛋白质的多聚体组成性地定位于内部着丝粒板，并在活性着丝粒-着丝粒复合体的组织和功能中发挥重要作用。[RefSeq 提供，2008 年 7 月]

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]