NUF2 - NUF2 component of NDC80 kinetochore complex Gene

中文名称：NDC80 着丝粒复合体的 NUF2 成分

种属: Homo sapiens

同用名: CDCA1; CT106; NUF2R

关于 NUF2

功能概要

该基因编码的蛋白质与酵母 Nuf2 高度相似，后者是与着丝粒相关的保守蛋白质复合物的组成部分。在减数分裂前期，当着丝粒失去与纺锤体极体的连接时，酵母 Nuf2 从着丝粒中消失，并在染色体分离中发挥调节作用。发现所编码的蛋白质与有丝分裂 HeLa 细胞的着丝粒相关，这表明该蛋白质是酵母 Nuf2 的功能同系物。已经描述了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]