2. Gene
  3. CENPE - centromere protein E Gene

CENPE - centromere protein E Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：着丝粒蛋白 E

种属: Homo sapiens

同用名: KIF10; CENP-E; MCPH13; PPP1R61

基因 ID: 1062 | 基因类型: protein coding

关于 CENPE

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,105,811-103,198,343 (from NCBI)

This gene has 6 transcripts (splice variants), 147 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 3.4), lymph node (RPKM 3.3) and 18 other tissues.

功能概要

中心体相关蛋白 E (CENPE) 是一种驱动蛋白样运动蛋白，在细胞周期的 G2 期积累。与其他中心体相关蛋白不同，它不存在于间期，而是在前中期首先出现在染色体的着丝粒区域。这种蛋白质是在着丝粒处稳定纺锤体微管捕获所必需的，这是前中期染色体排列的必要步骤。这种蛋白质还将染色体位置与微管解聚活性结合起来。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2014 年 11 月]

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

CENPE 基因产物(17)

mRNA Protein Name
XM_047449534.1 XP_047305490.1 centromere-associated protein E isoform X5
XM_011531549.3 XP_011529851.1 centromere-associated protein E isoform X10
XM_011531544.3 XP_011529846.1 centromere-associated protein E isoform X1
XM_047449541.1 XP_047305497.1 centromere-associated protein E isoform X15
XM_017007659.2 XP_016863148.1 centromere-associated protein E isoform X12
XM_047449538.1 XP_047305494.1 centromere-associated protein E isoform X11
NM_001286734.2 NP_001273663.1 centromere-associated protein E isoform 2
XM_011531547.3 XP_011529849.1 centromere-associated protein E isoform X6
XM_047449540.1 XP_047305496.1 centromere-associated protein E isoform X14
XM_011531545.3 XP_011529847.1 centromere-associated protein E isoform X2
XM_047449539.1 XP_047305495.1 centromere-associated protein E isoform X13
XM_011531548.3 XP_011529850.1 centromere-associated protein E isoform X7
XM_011531546.4 XP_011529848.1 centromere-associated protein E isoform X3
XM_047449535.1 XP_047305491.1 centromere-associated protein E isoform X8
XM_047449536.1 XP_047305492.1 centromere-associated protein E isoform X9
NM_001813.3 NP_001804.2 centromere-associated protein E isoform 1 precursor
XM_047449533.1 XP_047305489.1 centromere-associated protein E isoform X4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinetochore binding IDA
IDA: 通过直接分析推断
9763420 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
25908662 GOA
enables microtubule motor activity IDA
IDA: 通过直接分析推断
25908662 GOA
enables microtubule motor activity IMP
IMP: 通过突变表型推断
7889940 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9763420 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
15843429 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
24748105 GOA
involved in kinetochore assembly IDA
IDA: 通过直接分析推断
9763420 GOA
involved in lateral attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
23891108 GOA
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
23891108 GOA
involved in microtubule plus-end directed mitotic chromosome migration IDA
IDA: 通过直接分析推断
25908662 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
24748105 GOA
involved in mitotic chromosome movement towards spindle pole IDA
IDA: 通过直接分析推断
25908662 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
15843429 GOA
involved in mitotic spindle organization IMP
IMP: 通过突变表型推断
25908662 GOA
involved in positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
12925705 GOA
involved in regulation of mitotic metaphase/anaphase transition IMP
IMP: 通过突变表型推断
2022189 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
2022189 GOA
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
2022189 GOA
located in condensed chromosome, centromeric region IDA
IDA: 通过直接分析推断
19465021 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
9763420 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
25908662 GOA
located in microtubule IDA
IDA: 通过直接分析推断
7889940 GOA
located in midbody IDA
IDA: 通过直接分析推断
2022189 GOA
located in mitotic spindle midzone IDA
IDA: 通过直接分析推断
2022189 GOA
located in nucleus IMP
IMP: 通过突变表型推断
9763420 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
9763420 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CENPE 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (12 - 327)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2701 a.a.
蛋白主名 其他名称

centromere-associated protein E

Centromere autoantigen E (312kD)

centromere protein E, 312kDa

kinesin family member 10

kinesin-7

kinesin-related protein CENPE

protein phosphatase 1, regulatory subunit 61

CENPE 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CENPE Q02224 BUB1B Homo sapiens O60566
Anti Bait CoIP
9763420
Intra CENPE Q02224 NUF2 Homo sapiens Q9BZD4
Pull Down
17535814
Intra CENPE Q02224 NUF2 Homo sapiens Q9BZD4
IF
17535814
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome

MVA1

Mosaic Variegated Aneuploidy Syndrome, Type 1

Mosaic Variegated Aneuploidy Syndrome

Congenital Chromosomal Disease
Microcephaly 13, Primary, Autosomal Recessive

MCPH13

Primary Autosomal Recessive Microcephaly 13

Microcephaly, Type 13, Primary, Autosomal Recessive
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Microcephaly 5, Primary, Autosomal Recessive

MCPH5

Primary Autosomal Recessive Microcephaly 5

Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern

Microcephaly, Primary Autosomal Recessive, 5
Primary Microcephaly

True Microcephaly

Microcephaly, Primary
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-10299 GSK-923295 99.82% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19530 PF-2771 Inhibitor 99.66% 否
HY-121569 Syntelin Inhibitor 98.25% 否
HY-161897 CENP-E-IN-2 Inhibitor / 否
HY-161898 CENP-E-IN-3 Inhibitor / 否
HY-RS02476 CENPE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02477 Cenpe Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02478 Cenpe Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CENPE VGNC VGNC:27175
Mus musculus CENPE MGD MGI:1098230
Macaca mulatta CENPE VGNC VGNC:71008
Felis catus CENPE VGNC VGNC:60754
Canis familiaris CENPE VGNC VGNC:39103
Rattus norvegicus CENPE RGD RGD:1307115
Others CENPE NCBI
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