1. Gene
  2. PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

中文名称:蛋白磷酸酶 1 调节亚基 13B

种属: Homo sapiens

同用名: p85; ASPP1; p53BP2-like

基因 ID: 23368 | 基因类型: protein coding

关于 PPP1R13B

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,733,195-103,848,814 (from NCBI)

This gene has 18 transcripts (splice variants), 282 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues.

功能概要

该基因编码 p53 相互作用蛋白的 ASPP (p53 凋亡刺激蛋白) 家族的成员。该蛋白质包含四个锚蛋白重复序列和一个参与蛋白质-蛋白质相互作用的 SH3 结构域。 ASPP 蛋白是 p53 家族蛋白诱导细胞凋亡所必需的。它们促进 p53 家族蛋白在促凋亡基因启动子上的 DNA 结合和反式激活。该基因的表达受 E2F 转录因子调控。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of Apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

PPP1R13B 基因产物(1)

mRNA Protein Name
NM_015316.3 NP_056131.2 apoptosis-stimulating of p53 protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11684014 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: 通过直接分析推断
11684014 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11684014 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPP1R13B 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (898 - 980)

SH3_1

SH3_1: SH3 domain (1026 - 1072)

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  • 1090 a.a.
蛋白主名 其他名称

apoptosis-stimulating of p53 protein 1

apoptosis-stimulating protein of p53, 1

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPP1R13B MGD MGI:1336199
Rattus norvegicus PPP1R13B RGD RGD:1304651
Felis catus PPP1R13B VGNC VGNC:64318
Canis familiaris PPP1R13B VGNC VGNC:44881
Bos taurus PPP1R13B VGNC VGNC:33224
Macaca mulatta PPP1R13B VGNC VGNC:76259