PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

中文名称：蛋白磷酸酶 1 调节亚基 13B

种属: Homo sapiens

同用名: p85; ASPP1; p53BP2-like

关于 PPP1R13B

功能概要

该基因编码 p53 相互作用蛋白的 ASPP (p53 凋亡刺激蛋白) 家族的成员。该蛋白质包含四个锚蛋白重复序列和一个参与蛋白质-蛋白质相互作用的 SH3 结构域。 ASPP 蛋白是 p53 家族蛋白诱导细胞凋亡所必需的。它们促进 p53 家族蛋白在促凋亡基因启动子上的 DNA 结合和反式激活。该基因的表达受 E2F 转录因子调控。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of Apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]