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  2. CDC5L - cell division cycle 5 like Gene

CDC5L - cell division cycle 5 like Gene

中文名称:细胞分裂周期 5

种属: Homo sapiens

同用名: CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1

基因 ID: 988 | 基因类型: protein coding

关于 CDC5L

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,387,706-44,450,425 (from NCBI)

Ubiquitous expression in testis (RPKM 9.6), bone marrow (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码的蛋白质与 Schizosaccharomyces pombe cdc5 基因产物具有显着相似性,后者是一种对 G2/M 转换很重要的细胞周期调节因子。这种蛋白质已被证明可作为细胞周期 G2/M 进程的正调节剂。它还被发现是非 snRNA 剪接体的重要组成部分,它包含至少五个额外的蛋白质因子,并且是 pre-mRNA 剪接的第二个催化步骤所必需的。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

CDC5L 基因产物(1)

mRNA Protein Name
NM_001253.4 NP_001244.1 cell division cycle 5-like protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11082045 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11082045 GOA
enables WD40-repeat domain binding IDA
IDA: 通过直接分析推断
20176811 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20176811 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12927788 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
24332808 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11082045 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA replication factor A complex IDA
IDA: 通过直接分析推断
24332808 GOA
part of Prp19 complex IDA
IDA: 通过直接分析推断
20176811 GOA
part of Prp19 complex IPI
IPI: 通过物理相互作用推断
20176811 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9038199 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
16332694 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20176811 GOA
part of spliceosomal complex IPI
IPI: 通过物理相互作用推断
20176811 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDC5L 蛋白结构

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (11 - 71)

Myb_Cef

Myb_Cef: pre-mRNA splicing factor component (404 - 660)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
蛋白主名 其他名称

cell division cycle 5-like protein

CDC5 cell division cycle 5-like

CDC5L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDC5L Q99459 GOLGA8F Homo sapiens Q08AF8
Y2H Prey Pooling
25416956
Intra CDC5L Q99459 GOLGA8F Homo sapiens Q08AF8
Y2H Array
25416956
Intra CDC5L Q99459 GOLGA8DP Homo sapiens Q0D2H9
Y2H Prey Pooling
25416956
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Crosslink
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Solution Sedimentation
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Anti Bait CoIP
20467437
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Comigration in SDS
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Enzymatic Footprint
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
EM
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Far-WB
20176811
Intra CDC5L Q99459 BCAS2 Homo sapiens O75934
Density Sedimentation
20176811
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
Comigration in SDS
20176811
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
Density Sedimentation
20176811
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
EM
20176811
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
Solution Sedimentation
20176811
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
FRET
20467437
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
Anti Bait CoIP
20467437
Intra CDC5L Q99459 PLRG1 Homo sapiens O43660
Enzymatic Footprint
20176811
Intra CDC5L Q99459 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra CDC5L Q99459 PPP1R13B Homo sapiens Q96KQ4
Y2H Fragment Pooling
31413325
Intra CDC5L Q99459 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra CDC5L Q99459 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra CDC5L Q99459 TTF2 Homo sapiens Q9UNY4
Y2H
12927788
Intra CDC5L Q99459 SF3A2 Homo sapiens Q15428
Anti Bait CoIP
20467437
Intra CDC5L Q99459 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra CDC5L Q99459 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra CDC5L Q99459 SPTBN1 Homo sapiens Q01082
Anti Bait CoIP
20467437
Intra CDC5L Q99459 SPTBN1 Homo sapiens Q01082
Y2H Fragment Pooling
31413325
Intra CDC5L Q99459 SYNPO Homo sapiens Q8N3V7
Y2H Array
32296183
Intra CDC5L Q99459 SYNPO Homo sapiens Q8N3V7
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 PPP1CA Homo sapiens P62136
Anti Bait CoIP
20467437
Intra CDC5L Q99459 HNRNPC Homo sapiens P07910
Crosslink
30021884
Intra CDC5L Q99459 HNRNPC Homo sapiens P07910
Anti Bait CoIP
20467437
Intra CDC5L Q99459 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
EM
20176811
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Density Sedimentation
20176811
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Solution Sedimentation
20176811
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Anti Bait CoIP
20467437
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Enzymatic Footprint
20176811
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Far-WB
20176811
Intra CDC5L Q99459 PRPF19 Homo sapiens Q9UMS4
Comigration in SDS
20176811
Intra CDC5L Q99459 ORC2 Homo sapiens Q13416
Anti Bait CoIP
20467437
Intra CDC5L Q99459 HNRNPM Homo sapiens P52272
Anti Bait CoIP
20467437
Intra CDC5L Q99459 HNRNPM Homo sapiens P52272
FRET
20467437
Intra CDC5L Q99459 HNRNPM Homo sapiens P52272
Pull Down
20467437
Intra CDC5L Q99459 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra CDC5L Q99459 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra CDC5L Q99459 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra CDC5L Q99459 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra CDC5L Q99459 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 KDM1A Homo sapiens O60341
Y2H Fragment Pooling
31413325
Intra CDC5L Q99459 KDM1A Homo sapiens O60341
Anti Bait CoIP
20467437
Intra CDC5L Q99459 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra CDC5L Q99459 KANSL1 Homo sapiens Q7Z3B3
Anti Bait CoIP
20467437
Intra CDC5L Q99459 KANSL1 Homo sapiens Q7Z3B3
Y2H Fragment Pooling
31413325
Intra CDC5L Q99459 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra CDC5L Q99459 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 HOOK1 Homo sapiens Q9UJC3
Validated Y2H
32296183
Intra CDC5L Q99459 HOOK1 Homo sapiens Q9UJC3
Y2H Array
32296183
Intra CDC5L Q99459 HOOK1 Homo sapiens Q9UJC3
Y2H Prey Pooling
32296183
Intra CDC5L Q99459 HOOK1 Homo sapiens Q9UJC3
Y2H Fragment Pooling
31413325
Intra CDC5L Q99459 CTNNBL1 Homo sapiens Q8WYA6
Comigration in SDS
20176811
Intra CDC5L Q99459 CTNNBL1 Homo sapiens Q8WYA6
EM
20176811
Intra CDC5L Q99459 CTNNBL1 Homo sapiens Q8WYA6
Far-WB
20176811
Intra CDC5L Q99459 CTNNBL1 Homo sapiens Q8WYA6
Solution Sedimentation
20176811
Intra CDC5L Q99459 CTNNBL1 Homo sapiens Q8WYA6
Enzymatic Footprint
20176811
Intra CDC5L Q99459 ATR Homo sapiens Q13535
Anti Bait CoIP
19633697
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Renal Dysplasia

Kidney Dysplasia

Renal Cell Dysplasia

Congenital Renal Dysplasia

Dysplasia Of Kidney

Dysplastic Kidney

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type

PN

Clericuzio Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio-Type

Clericuzio-Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia Clericuzio Type

Immune-Deficient Poikiloderma

Clericuzio-Type Poikiloderma Neutropenia Syndrome

Poikiloderma With Neutropenia Clericuzio-Type

Poikiloderma, With Neutropenia

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma

Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CDC5L MGD MGI:1918952
Bos taurus CDC5L VGNC VGNC:27080
Felis catus CDC5L VGNC VGNC:60663
Rattus norvegicus CDC5L RGD RGD:70892
Macaca mulatta CDC5L VGNC VGNC:70801
Canis familiaris CDC5L VGNC VGNC:39008