TTF2 - transcription termination factor 2 Gene

中文名称：转录终止因子 2

种属: Homo sapiens

同用名: F2; HuF2; ZGRF6

基因 ID: 8458 | 基因类型: protein coding

关于 TTF2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,060,326-117,107,453 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues and 30 paralogues. Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues.

功能概要

该基因编码 SWI2/SNF2 蛋白家族的成员，该蛋白在改变蛋白质-DNA 相互作用中起着关键作用。编码的蛋白质已显示具有 dsDNA 依赖性 ATP 酶活性和 RNA 聚合酶 II 终止活性。这种蛋白质与细胞分裂周期 5 样相互作用，与人类剪接复合物相关，并在 pre-mRNA 剪接中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

TTF2 基因产物(1)

mRNA	Protein	Name
NM_003594.4	NP_003585.3	transcription termination factor 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP-dependent activity, acting on DNA	IDA IDA: 通过直接分析推断	9748214	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12927788	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TTF2 蛋白结构

zf-GRF

SNF2_N

Helicase_C

0
200
400
600
800
1000
1162 a.a.

蛋白主名

其他名称

transcription termination factor 2

RNA polymerase II termination factor

TTF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TTF2	Q9UNY4	CDC5L	Homo sapiens	Q99459	Anti Bait CoIP	12927788
种属内	TTF2	Q9UNY4	CDC5L	Homo sapiens	Q99459	Chromatography	12927788

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Sexual Sadism

Sadism

Narcissistic Personality Disorder

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Brunner Syndrome

Monoamine Oxidase A Deficiency	Antisocial Behavior
BRNRS	Deficiency Of Monoamine Oxidase A
X-Linked Monoamine Oxidase Deficiency	Susceptibility To Antisocial Behavior
Antisocial Behavior, Susceptibility To	Anti-Social Behavior

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Resting Heart Rate, Variation In

Resting Heart Rate	Rhr
Resting Heart Rate, Variation

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15223	TTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TTF2	VGNC	VGNC:82263
Rattus norvegicus	TTF2	RGD	RGD:1309145
Canis familiaris	TTF2	VGNC	VGNC:47968
Mus musculus	TTF2	MGD	MGI:1921294
Bos taurus	TTF2	VGNC	VGNC:36484
Felis catus	TTF2	VGNC	VGNC:66680

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