2. Gene
  3. PRPF19 - pre-mRNA processing factor 19 Gene

PRPF19 - pre-mRNA processing factor 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：pre-mRNA 加工因子 19

种属: Homo sapiens

同用名: PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200

基因 ID: 27339 | 基因类型: protein coding

关于 PRPF19

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,890,547-60,906,585 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 44.9), ovary (RPKM 35.1) and 25 other tissues.

功能概要

PSO4 是酵母 Pso4 的人类同系物，是细胞存活和 DNA 修复所必需的基因 (Beck 等人，2008 [PubMed 18263876]) 。[OMIM 提供，2008 年 9 月]

PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

PRPF19 基因产物(1)

mRNA Protein Name
NM_014502.5 NP_055317.1 pre-mRNA-processing factor 19
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16332694 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19188445 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
11435423 GOA
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
20595234 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
11435423 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
24332808 GOA
involved in double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
18263876 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
20176811 GOA
involved in proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
17349974 GOA
involved in protein K63-linked ubiquitination IMP
IMP: 通过突变表型推断
20595234 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
18263876 GOA
acts upstream of or within protein polyubiquitination IDA
IDA: 通过直接分析推断
11435423 GOA
involved in spliceosomal complex assembly IMP
IMP: 通过突变表型推断
16332694 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: 通过直接分析推断
20595234 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA replication factor A complex IDA
IDA: 通过直接分析推断
24332808 GOA
part of Prp19 complex IDA
IDA: 通过直接分析推断
20176811 GOA
part of Prp19 complex IPI
IPI: 通过物理相互作用推断
20176811 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11435423 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
16332694 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11435423 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
18263876 GOA
part of spliceosomal complex IPI
IPI: 通过物理相互作用推断
20176811 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRPF19 蛋白结构

U-box

U-box: U-box domain (3 - 54)

Prp19

Prp19: Prp19/Pso4-like (67 - 134)

WD40

WD40: WD domain, G-beta repeat (256 - 292)

WD40

WD40: WD domain, G-beta repeat (297 - 327)

WD40

WD40: WD domain, G-beta repeat (353 - 378)

WD40

WD40: WD domain, G-beta repeat (384 - 420)

WD40

WD40: WD domain, G-beta repeat (466 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

pre-mRNA-processing factor 19

PRP19/PSO4 homolog

PRPF19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
22365833
种属内
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
35271311
种属内
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Far-WB
20176811
种属内
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
28514442
种属内
PRPF19 Q9UMS4 PLRG1 Homo sapiens O43660
Anti Tag CoIP
35271311
种属内
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
33961781
种属内
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
28514442
种属内
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
22365833
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Pull Down
20176811
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
35271311
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
33961781
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
28514442
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Pull Down
19633697
种属内
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Far-WB
20176811
种属内
PRPF19 Q9UMS4 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
33961781
种属内
PRPF19 Q9UMS4 RBM5 Homo sapiens P52756
Anti Tag CoIP
22569250
种属间: 跨种属相互作用 种属内: 同种属相互作用

PRPF19 抗体

目录号 产品名 应用 反应物种
HY-P83313 PRPF19 Antibody (YA3058) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type

PN

Clericuzio Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio-Type

Clericuzio-Type Poikiloderma With Neutropenia

Poikiloderma With Neutropenia Clericuzio Type

Immune-Deficient Poikiloderma

Clericuzio-Type Poikiloderma Neutropenia Syndrome

Poikiloderma With Neutropenia Clericuzio-Type

Poikiloderma, With Neutropenia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11206 PRPF19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PRPF19 VGNC VGNC:33372
Canis familiaris PRPF19 VGNC VGNC:45019
Rattus norvegicus PRPF19 RGD RGD:708496
Mus musculus PRPF19 MGD MGI:106247
Felis catus PRPF19 VGNC VGNC:64369
Macaca mulatta PRPF19 VGNC VGNC:76281
Others PRPF19 NCBI
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