2. Gene
  3. CDC40 - cell division cycle 40 Gene

CDC40 - cell division cycle 40 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂周期 40

种属: Homo sapiens

同用名: EHB3; PCH15; PRP17; PRPF17

基因 ID: 51362 | 基因类型: protein coding

关于 CDC40

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,180,427-110,232,232 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 12.9), lymph node (RPKM 10.6) and 25 other tissues.

功能概要

pre-mRNA 剪接发生在两个连续的酯交换步骤中。发现由该基因编码的蛋白质对于前体 mRNA 剪接过程中的催化步骤 II 是必不可少的。它存在于剪接体中，包含七个 WD 重复序列，在蛋白质-蛋白质相互作用中发挥作用。该蛋白与酵母 Prp17 蛋白具有序列相似性，后者在两个不同的细胞过程中发挥作用：pre-mRNA 剪接和细胞周期进程。这表明这种蛋白质可能在细胞周期进程中发挥作用。[RefSeq 提供，2008 年 7 月]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]

CDC40 基因产物(1)

mRNA Protein Name
NM_015891.3 NP_056975.1 pre-mRNA-processing factor 17
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22365833 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in embryonic brain development IMP
IMP: 通过突变表型推断
33220177 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
33220177 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
9830021 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC40 蛋白结构

WD40

WD40: WD domain, G-beta repeat (279 - 317)

WD40

WD40: WD domain, G-beta repeat (323 - 360)

WD40

WD40: WD domain, G-beta repeat (366 - 404)

WD40

WD40: WD domain, G-beta repeat (408 - 446)

WD40

WD40: WD domain, G-beta repeat (513 - 536)

WD40

WD40: WD domain, G-beta repeat (544 - 579)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
蛋白主名 其他名称

pre-mRNA-processing factor 17

EH-binding protein 3

CDC40 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC40 O60508 PRPF19 Homo sapiens Q9UMS4
Y2H
22365833
种属间: 跨种属相互作用 种属内: 同种属相互作用

CDC40 抗体

目录号 产品名 应用 反应物种
HY-P83423 CDC40 Antibody (YA3168) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 15

PCH15

Pontocerebellar Hypoplasia Type 15

Pontocerebellar Hypoplasia 15

Doid:0112326
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy

Quadriplegic Infantile Cerebral Palsy

Tetraplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Quadriplegic

Quadriplegic Cerebral Palsy

Spastic Quadriplegia Cerebral Palsy

Spastic Tetraplegia Cerebral Palsy

Cerebral Palsy, Quadriplegic, Infantile

Cerebral Palsy With Spastic Tetraplegia

Congenital Spastic Quadriplegia

Spastic Tetraplegic Cerebral Palsy

Congenital Quadriplegia Nos

Tetraplegic Cerebral Palsy
Quadriplegia

Tetraplegia

Tetraplegias
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02299 CDC40 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CDC40 MGD MGI:1918963
Rattus norvegicus CDC40 RGD RGD:1307063
Bos taurus CDC40 VGNC VGNC:27068
Macaca mulatta CDC40 VGNC VGNC:70798
Canis familiaris CDC40 VGNC VGNC:38996
Felis catus CDC40 VGNC VGNC:60656
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