2. Gene
  3. ZRANB1 - zinc finger RANBP2-type containing 1 Gene

ZRANB1 - zinc finger RANBP2-type containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含锌指 RANBP2 型 1

种属: Homo sapiens

同用名: TRABID

基因 ID: 54764 | 基因类型: protein coding

关于 ZRANB1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,916,894-124,988,189 (from NCBI)

This gene has 2 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues.

功能概要

启用 K63 连接的多聚泛素修饰依赖性蛋白结合活性和硫醇依赖性去泛素化酶。参与多个过程，包括 Wnt 信号通路的正调控；蛋白质去泛素化；和细胞形态发生的调节。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB1 基因产物(1)

mRNA Protein Name
NM_017580.3 NP_060050.2 ubiquitin thioesterase ZRANB1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
18281465 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
18281465 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
18281465 GOA
enables deubiquitinase activity IDA
IDA: 通过直接分析推断
33637724 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
25752573 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11463333 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IMP
IMP: 通过突变表型推断
21834987 GOA
involved in cytoskeleton organization IMP
IMP: 通过突变表型推断
21834987 GOA
involved in positive regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
18281465 GOA
involved in protein K29-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein K33-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein K63-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein K63-linked deubiquitination IMP
IMP: 通过突变表型推断
18281465 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
33637724 GOA
involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
18281465 GOA
involved in regulation of cell morphogenesis IMP
IMP: 通过突变表型推断
21834987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
25752577 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11463333 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
25752577 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11463333 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZRANB1 蛋白结构

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (7 - 33)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (151 - 177)

OTU

OTU: OTU-like cysteine protease (439 - 586)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

ubiquitin thioesterase ZRANB1

TRAF-binding domain-containing protein

ZRANB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZRANB1 Q9UGI0 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 POLL Homo sapiens Q9UGP5-2
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 METAP1 Homo sapiens P53582
MAPPIT
32296183
Intra ZRANB1 Q9UGI0 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 PSPC1 Homo sapiens Q8WXF1-2
Y2H Array
32296183
Intra ZRANB1 Q9UGI0 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 TBC1D30 Homo sapiens Q9Y2I9-2
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 CCNL1 Homo sapiens Q9UK58
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 VAV3 Homo sapiens Q9UKW4
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 TSPYL4 Homo sapiens Q9UJ04
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 UBC Homo sapiens P0CG48
Enzymatic Study
19373254
Intra ZRANB1 Q9UGI0 UBC Homo sapiens P0CG48
Pull Down
19373254
Intra ZRANB1 Q9UGI0 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 ARHGEF5 Homo sapiens Q12774
Y2H Prey Pooling
32296183
Intra ZRANB1 Q9UGI0 BAHD1 Homo sapiens Q8TBE0
Y2H Array
32296183
Intra ZRANB1 Q9UGI0 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 DUSP13B Homo sapiens Q9UII6
Validated Y2H
32296183
Intra ZRANB1 Q9UGI0 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16193 ZRANB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZRANB1 VGNC VGNC:79119
Canis familiaris ZRANB1 VGNC VGNC:48847
Mus musculus ZRANB1 MGD MGI:106441
Rattus norvegicus ZRANB1 RGD RGD:2321751
Felis catus ZRANB1 VGNC VGNC:67379
Bos taurus ZRANB1 VGNC VGNC:37371
Others ZRANB1 NCBI
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