2. Gene
  3. ARHGEF5 - Rho guanine nucleotide exchange factor 5 Gene

ARHGEF5 - Rho guanine nucleotide exchange factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho 鸟嘌呤核苷酸交换因子 5

种属: Homo sapiens

同用名: P60; TIM; GEF5; TIM1

基因 ID: 7984 | 基因类型: protein coding

关于 ARHGEF5

Cytogenetic location: 7q35 Genomic coordinates (GRCh38): 7:144,355,402-144,380,632 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 198 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 23.4), skin (RPKM 15.6) and 23 other tissues.

功能概要

Rho GTP 酶在通过 G 蛋白偶联受体发挥作用的细胞外刺激启动的众多细胞过程中起着重要作用。编码的蛋白质可能与 G 蛋白形成复合物并刺激 Rho 依赖性信号。这种蛋白质可能参与细胞骨架组织的控制。[RefSeq 提供，2008 年 7 月]

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

ARHGEF5 基因产物(1)

mRNA Protein Name
NM_005435.4 NP_005426.2 rho guanine nucleotide exchange factor 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
15601624 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12006984 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15601624 GOA
involved in positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
15601624 GOA
involved in positive regulation of protein import IMP
IMP: 通过突变表型推断
15601624 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
15601624 GOA
NOT involved in regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
15601624 GOA
acts upstream of or within regulation of GTPase activity IDA
IDA: 通过直接分析推断
21525037 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
14662653 GOA
involved in regulation of cytoskeleton organization IMP
IMP: 通过突变表型推断
15601624 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
25911094 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
14662653 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14662653 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGEF5 蛋白结构

ARHGEF5_35

ARHGEF5_35: Rho guanine nucleotide exchange factor 5/35 (1 - 478)

RhoGEF

RhoGEF: RhoGEF domain (1180 - 1356)

SH3_9

SH3_9: Variant SH3 domain (1520 - 1566)

  • 0
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  • 1200
  • 1500
  • 1597 a.a.
蛋白主名 其他名称

rho guanine nucleotide exchange factor 5

Rho guanine nucleotide exchange factor (GEF) 5

ARHGEF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Validated Y2H
32296183
Intra ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
Intra ARHGEF5 Q12774 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 POLR1C Homo sapiens O15160
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 POLR1C Homo sapiens O15160
Y2H Array
32296183
Intra ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Validated Y2H
32296183
Intra ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 MB21D2 Homo sapiens Q8IYB1
Y2H Array
32296183
Intra ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Y2H Array
32296183
Intra ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 LRATD1 Homo sapiens Q96KN4
Validated Y2H
32296183
Intra ARHGEF5 Q12774 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra ARHGEF5 Q12774 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Y2H Array
32296183
Intra ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 TBC1D13 Homo sapiens Q9NVG8
Validated Y2H
32296183
Intra ARHGEF5 Q12774 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra ARHGEF5 Q12774 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
25416956
Intra ARHGEF5 Q12774 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
BFG-2H
27107012
Intra ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra ARHGEF5 Q12774 GRB2 Homo sapiens P62993
Anti Tag CoIP
32203420
Intra ARHGEF5 Q12774 GRB2 Homo sapiens P62993
Anti Bait CoIP
24189400
Intra ARHGEF5 Q12774 RHOA Homo sapiens P61586
Enzymatic Study
12006984
Intra ARHGEF5 Q12774 SFN Homo sapiens P31947
TAP
15778465
Intra ARHGEF5 Q12774 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra ARHGEF5 Q12774 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Y2H Array
32296183
Intra ARHGEF5 Q12774 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra ARHGEF5 Q12774 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra ARHGEF5 Q12774 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Validated Y2H
32296183
Intra ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Array
25416956
Intra ARHGEF5 Q12774 HSPBAP1 Homo sapiens Q96EW2
Y2H Array
32296183
Intra ARHGEF5 Q12774 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra ARHGEF5 Q12774 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rippling Muscle Disease 2

Rippling Muscle Disease

Rmd

Lgmd1c

RMD2

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c

Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly

Lgmd1c, Formerly

Limb-Girdle Muscular Dystrophy Type 1c

Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency

Muscular Dystrophy, Limb-Girdle, Type Ic

Rippling Muscle Syndrome

Limb-Girdle Muscular Dystrophy 1c

Dystrophy, Muscular, Limb-Girdle, Type 1c

Disease, Muscle, Rippling, Type 2

Rippling Muscle Disease 1
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00962 ARHGEF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARHGEF5 VGNC VGNC:38090
Macaca mulatta ARHGEF5 VGNC VGNC:80793
Bos taurus ARHGEF5 VGNC VGNC:26119
Mus musculus ARHGEF5 MGD MGI:1858952
Rattus norvegicus ARHGEF5 RGD RGD:620718
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