TRIM27 - tripartite motif containing 27 Gene

中文名称：含三方基序 27

种属: Homo sapiens

同用名: RFP; RNF76

关于 TRIM27

功能概要

该基因编码三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白质定位于核基质。它与 polycomb 蛋白的增强子相互作用并抑制基因转录。它也被认为与雄性生殖细胞的分化有关。该蛋白的 N 端与 RET 基因产物的截短 C 端的融合已显示导致 RET 转化蛋白的产生。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the RET transforming protein. [provided by RefSeq, Jul 2008]