2. Gene
  3. GRB14 - growth factor receptor bound protein 14 Gene

GRB14 - growth factor receptor bound protein 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长因子受体结合蛋白 14

种属: Homo sapiens

基因 ID: 2888 | 基因类型: protein coding

关于 GRB14

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:164,492,417-164,621,482 (from NCBI)

This gene has 7 transcripts (splice variants), 221 orthologues and 4 paralogues. Biased expression in kidney (RPKM 7.9), liver (RPKM 7.8) and 12 other tissues.

功能概要

该基因的产物属于已知与许多受体酪氨酸激酶和信号分子相互作用的一小部分衔接蛋白。该基因编码与胰岛素受体和胰岛素样生长因子受体相互作用的生长因子受体结合蛋白。这种蛋白质可能对受体酪氨酸激酶信号传导具有抑制作用，特别是对胰岛素受体信号传导具有抑制作用。该基因可能在调节生长和代谢的信号通路中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with Insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on Insulin Receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GRB14 基因产物(2)

mRNA Protein Name
NM_001303422.2 NP_001290351.1 growth factor receptor-bound protein 14 isoform 2
NM_004490.3 NP_004481.2 growth factor receptor-bound protein 14 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
14623073 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
16246733 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
16246733 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11278563 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
11278563 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11278563 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRB14 蛋白结构

RA

RA: Ras association (RalGDS/AF-6) domain (107 - 190)

PH

PH: PH domain (237 - 340)

BPS

BPS: BPS (Between PH and SH2) (369 - 417)

SH2

SH2: SH2 domain (439 - 520)

  • 0
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  • 500
  • 540 a.a.
蛋白主名 其他名称

growth factor receptor-bound protein 14

GRB14 adapter protein

GRB14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GRB14 Q14449 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra GRB14 Q14449 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra GRB14 Q14449 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra GRB14 Q14449 TRIM27 Homo sapiens P14373
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05779 GRB14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GRB14 RGD RGD:61869
Bos taurus GRB14 VGNC VGNC:29630
Felis catus GRB14 VGNC VGNC:107550
Macaca mulatta GRB14 VGNC VGNC:73269
Mus musculus GRB14 MGD MGI:1355324
Canis familiaris GRB14 VGNC VGNC:41471
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