GSE1 - Gse1 coiled-coil protein Gene

中文名称：Gse1 卷曲螺旋蛋白

种属: Homo sapiens

同用名: CRHSP24; KIAA0182

基因 ID: 23199 | 基因类型: protein coding

关于 GSE1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,169,512-85,676,200 (from NCBI)

This gene has 16 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in placenta (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

功能概要

该基因编码一种富含脯氨酸的蛋白质，其具有卷曲螺旋结构域，可能是 BRAF35-HDAC (BHC) 组蛋白脱乙酰酶复合物的一个亚基。该基因可能在乳腺癌中起致癌基因的作用，并且已在乳腺癌患者中观察到编码蛋白的增强表达。[RefSeq 提供，2017 年 5 月]

This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast Cancer and enhanced expression of the encoded protein has been observed in breast Cancer patients. [provided by RefSeq, May 2017]

GSE1 基因产物(3)

mRNA	Protein	Name
NM_001134473.3	NP_001127945.1	genetic suppressor element 1 isoform 2
NM_001278184.3	NP_001265113.1	genetic suppressor element 1 isoform 3
NM_014615.5	NP_055430.1	genetic suppressor element 1 isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSE1 蛋白结构

DUF3736

0
200
400
600
800
1000
1217 a.a.

蛋白主名

其他名称

genetic suppressor element 1

CTC-786C10.1

GSE1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	GSE1	Q14687	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Pooling	16189514
Intra	GSE1	Q14687	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	GSE1	Q14687	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	25416956
Intra	GSE1	Q14687	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intraventricular Meningioma

Adult Medulloblastoma

Adult Brain Medulloblastoma

Medulloblastoma, Adult

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05859	GSE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	GSE1	VGNC	VGNC:41527
Mus musculus	GSE1	MGD	MGI:1098275
Bos taurus	GSE1	VGNC	VGNC:55049
Macaca mulatta	GSE1	VGNC	VGNC:73254
Felis catus	GSE1	VGNC	VGNC:108362
Rattus norvegicus	GSE1	RGD	RGD:1562686

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4