2. Gene
  3. CARD10 - caspase recruitment domain family member 10 Gene

CARD10 - caspase recruitment domain family member 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胱天蛋白酶招募域家族成员 10

种属: Homo sapiens

同用名: BIMP1; IMD89; CARMA3

基因 ID: 29775 | 基因类型: protein coding

关于 CARD10

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,490,362-37,519,415 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 15.9), duodenum (RPKM 15.0) and 22 other tissues.

功能概要

Caspase 募集域 (CARD) 是一种蛋白质模块，由 6 或 7 个反平行的 alpha 螺旋组成。它通过高度特异性的蛋白质-蛋白质嗜同性相互作用参与细胞凋亡信号传导。与其他几种 CARD 蛋白一样，CARD10 属于膜相关鸟苷酸激酶 (MAGUK) 家族并通过 BCL10 (MIM 603517) 激活 NF-kappa-B (NFKB；参见 MIM 164011) (Wang 等人，2001 [PubMed 11259443] ) .[OMIM 提供，2008 年 3 月]

The Caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in Apoptosis signaling through highly specific protein-protein homophilic interactions. Like several Other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

CARD10 基因产物(1)

mRNA Protein Name
NM_014550.4 NP_055365.2 caspase recruitment domain-containing protein 10
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11259443 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of NF-kappaB-inducing kinase activity IDA
IDA: 通过直接分析推断
11259443 GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
24863965 GOA
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
24863965 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARD10 蛋白结构

CARD

CARD: Caspase recruitment domain (28 - 114)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1032 a.a.
蛋白主名 其他名称

caspase recruitment domain-containing protein 10

Bcl10 binding protein and activator of NFKB

CARD10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CARD10 Q9BWT7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
CARD10 Q9BWT7 ZNF223 Homo sapiens Q9UK11
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
种属内
CARD10 Q9BWT7 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
种属内
CARD10 Q9BWT7 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 ZNF286A Homo sapiens Q9HBT8
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 METTL17 Homo sapiens Q9H7H0-2
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
种属内
CARD10 Q9BWT7 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
种属内
CARD10 Q9BWT7 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
种属内
CARD10 Q9BWT7 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 ZNF180 Homo sapiens Q9UJW8-4
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 MGC50722 Homo sapiens Q8IVT4
Y2H Array
32296183
种属内
CARD10 Q9BWT7 ZNF552 Homo sapiens Q9H707
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 KRT75 Homo sapiens O95678
Y2H Array
32296183
种属内
CARD10 Q9BWT7 GSTP1 Homo sapiens P09211
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
CARD10 Q9BWT7 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
种属内
CARD10 Q9BWT7 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
种属内
CARD10 Q9BWT7 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 TRIM27 Homo sapiens P14373
Y2H Array
32296183
种属内
CARD10 Q9BWT7 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 GFAP Homo sapiens P14136
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 GFAP Homo sapiens P14136
Y2H Array
32296183
种属内
CARD10 Q9BWT7 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
种属内
CARD10 Q9BWT7 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
种属内
CARD10 Q9BWT7 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
种属内
CARD10 Q9BWT7 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 89 And Autoimmunity

IMD89
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary
Immunodeficiency 11

Immunodeficiency 11a

Severe Combined Immunodeficiency Due To Card11 Deficiency

IMD11A

Imd11

Card11 Immunodeficiency

Scid Due To Card11 Deficiency

Card11 Deficiency

Immunodeficiency 11 A
Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia
Pityriasis Rubra Pilaris

PRP

Devergie'S Disease

Prp - [Pityriasis Rubra Pilaris]
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5

Arrhythmogenic Right Ventricular Dysplasia 5

ARVD5

Arrhythmogenic Right Ventricular Cardiomyopathy 5

Arvc5

Familial Arrhythmogenic Right Ventricular Dysplasia 5

Dysplasia, Ventricular, Right, Arrhythmogenic, Type 5
Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01915 CARD10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CARD10 RGD RGD:1304949
Mus musculus CARD10 MGD MGI:2146012
Canis familiaris CARD10 VGNC VGNC:38713
Felis catus CARD10 VGNC VGNC:60363
Macaca mulatta CARD10 VGNC VGNC:70570
Bos taurus CARD10 VGNC VGNC:26760
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