2. Gene
  3. CHIC2 - cysteine rich hydrophobic domain 2 Gene

CHIC2 - cysteine rich hydrophobic domain 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富半胱氨酸的疏水结构域 2

种属: Homo sapiens

同用名: BTL

基因 ID: 26511 | 基因类型: protein coding

关于 CHIC2

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:54,009,789-54,091,879 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 41 phenotypes. Ubiquitous expression in testis (RPKM 2.4), gall bladder (RPKM 1.4) and 25 other tissues.

功能概要

该基因编码 CHIC 蛋白质家族的成员。编码的蛋白质包含富含半胱氨酸的疏水 (CHIC) 基序，并定位于囊泡结构和质膜。该基因与一些急性髓性白血病病例有关。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]

CHIC2 基因产物(1)

mRNA Protein Name
NM_012110.4 NP_036242.1 cysteine-rich hydrophobic domain-containing protein 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHIC2 蛋白结构

Erf4

Erf4: Golgin subfamily A member 7/ERF4 family (39 - 141)

  • 0
  • 100
  • 165 a.a.
蛋白主名 其他名称

cysteine-rich hydrophobic domain-containing protein 2

BRX-like translocated in leukemia

CHIC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CHIC2 Q9UKJ5 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra CHIC2 Q9UKJ5 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra CHIC2 Q9UKJ5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE3C Homo sapiens Q5T5A8
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE3C Homo sapiens Q5T5A8
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 CDR2 Homo sapiens Q01850
Y2H Array
30886144
Intra CHIC2 Q9UKJ5 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
25416956
Intra CHIC2 Q9UKJ5 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE1F Homo sapiens Q5T754
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCE1F Homo sapiens Q5T754
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra CHIC2 Q9UKJ5 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 ZNF837 Homo sapiens Q96EG3
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 ZNF837 Homo sapiens Q96EG3
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra CHIC2 Q9UKJ5 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra CHIC2 Q9UKJ5 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra CHIC2 Q9UKJ5 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 AXIN2 Homo sapiens Q9Y2T1
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 AXIN2 Homo sapiens Q9Y2T1
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 AXIN2 Homo sapiens Q9Y2T1
Validated Y2H
32296183
Intra CHIC2 Q9UKJ5 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 HOXA1 Homo sapiens P49639
Y2H Pooling
16189514
Intra CHIC2 Q9UKJ5 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 DNAL4 Homo sapiens O96015
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 DNAL4 Homo sapiens O96015
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
19060904
Intra CHIC2 Q9UKJ5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Pooling
19060904
Intra CHIC2 Q9UKJ5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Pooling
16189514
Intra CHIC2 Q9UKJ5 CATSPER1 Homo sapiens Q8NEC5
Y2H Pooling
16189514
Intra CHIC2 Q9UKJ5 PLEKHF1 Homo sapiens Q96S99
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 PLEKHF1 Homo sapiens Q96S99
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra CHIC2 Q9UKJ5 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 LCE3A Homo sapiens Q5TA76
Y2H Array
32296183
Intra CHIC2 Q9UKJ5 LCE3A Homo sapiens Q5TA76
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra CHIC2 Q9UKJ5 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra CHIC2 Q9UKJ5 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Disseminated Eosinophilic Collagen Disease
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement

Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement

Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Splenic Flexure Cancer

Ca Splenic Flexure - Colon

Malignant Neoplasm Of Splenic Flexure

Malignant Tumor Of Splenic Flexure

Malignant Neoplasm Of Splenic Flexure Of Colon
Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia
Endomyocardial Fibrosis

Becker'S Disease

Obscure African Cardiomyopathy

African Endomyocardial Fibrosis

Endomyocardial Sclerosis

EMF

Becker Muscular Dystrophy
Extracutaneous Mastocytoma

Mastocytoma

Mast Cell Neoplasm

Benign Mastocytoma
Sm-Ahnmd

Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease

Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease

Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy

Cardiomyopathy, Restrictive

Cardiomyopathy, Constrictive

Primary Restrictive Cardiomyopathy

Rcm

Cardiomyopathy Restrictive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02630 CHIC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CHIC2 VGNC VGNC:27293
Canis familiaris CHIC2 VGNC VGNC:39216
Felis catus CHIC2 VGNC VGNC:107319
Mus musculus CHIC2 MGD MGI:1921527
Rattus norvegicus CHIC2 RGD RGD:1309278
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