2. Gene
  3. NCOA1 - nuclear receptor coactivator 1 Gene

NCOA1 - nuclear receptor coactivator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体共激活因子 1

种属: Homo sapiens

同用名: SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74

基因 ID: 8648 | 基因类型: protein coding

关于 NCOA1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,491,254-24,770,702 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 83 phenotypes. Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues.

功能概要

由该基因编码的蛋白质充当类固醇和核激素受体的转录共激活因子。它是 p160/类固醇受体共激活因子 (Src) 家族的成员，与其他家族成员一样具有组蛋白乙酰转移酶活性，并包含核定位信号以及 bHLH 和 PAS 结构域。该基因的产物直接结合核受体并以激素依赖性方式刺激转录活动。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (Src) family and like other family members has Histone Acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

NCOA1 基因产物(7)

mRNA Protein Name
NM_001362950.1 NP_001349879.1 nuclear receptor coactivator 1 isoform 2
NM_001362952.1 NP_001349881.1 nuclear receptor coactivator 1 isoform 2
NM_001362954.1 NP_001349883.1 nuclear receptor coactivator 1 isoform 2
NM_001362955.1 NP_001349884.1 nuclear receptor coactivator 1 isoform 2
NM_003743.5 NP_003734.3 nuclear receptor coactivator 1 isoform 1
NM_147223.3 NP_671756.1 nuclear receptor coactivator 1 isoform 2
NM_147233.2 NP_671766.1 nuclear receptor coactivator 1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
18563714 GOA
enables nuclear receptor binding IDA
IDA: 通过直接分析推断
10207113 GOA
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
17363140 GOA
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
15919756 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9556555 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
10207113 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in estrogen receptor signaling pathway IDA
IDA: 通过直接分析推断
7481822 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16373399 GOA
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11891224 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15367689 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9223431 GOA
involved in positive regulation of transcription from RNA polymerase II promoter by galactose IDA
IDA: 通过直接分析推断
10207113 GOA
involved in progesterone receptor signaling pathway IDA
IDA: 通过直接分析推断
10757795 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
16373399 GOA
located in chromatin IDA
IDA: 通过直接分析推断
15831516 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15641800 GOA
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
12909012 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOA1 蛋白结构

PAS

PAS: PAS fold (115 - 172)

PAS_11

PAS_11: PAS domain (260 - 369)

SRC-1

SRC-1: Steroid receptor coactivator (630 - 708)

Nuc_rec_co-act

Nuc_rec_co-act: Nuclear receptor coactivator (924 - 973)

DUF1518

DUF1518: Domain of unknown function (DUF1518) (1149 - 1204)

DUF1518

DUF1518: Domain of unknown function (DUF1518) (1212 - 1268)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1441 a.a.
蛋白主名 其他名称

nuclear receptor coactivator 1

Hin-2 protein

NCOA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NCOA1 Q15788 PAGR1 Homo sapiens Q9BTK6
Anti Bait CoIP
19039327
Intra NCOA1 Q15788 PAGR1 Homo sapiens Q9BTK6
Anti Tag CoIP
19039327
Intra NCOA1 Q15788 KANK2 Homo sapiens Q63ZY3
Pull Down
17476305
Intra NCOA1 Q15788 VDR Homo sapiens P11473
GMS
21478865
Intra NCOA1 Q15788 VDR Homo sapiens P11473
Solution Sedimentation
21478865
Intra NCOA1 Q15788 TDG Homo sapiens Q13569
CH-IP
16282588
Intra NCOA1 Q15788 TDG Homo sapiens Q13569
Pull Down
16282588
Intra NCOA1 Q15788 NR1I2 Homo sapiens O75469
X-Ray Diffraction
23602807
Intra NCOA1 Q15788 NR1I2 Homo sapiens O75469
FPS
23602807
Intra NCOA1 Q15788 RARA Homo sapiens P10276
Y2H
17641689
Intra NCOA1 Q15788 RARA Homo sapiens P10276
Solution Sedimentation
21478865
Intra NCOA1 Q15788 RARA Homo sapiens P10276
GMS
21478865
Intra NCOA1 Q15788 PSMB9 Homo sapiens P28065
Anti Bait CoIP
16957778
Intra NCOA1 Q15788 PSMB9 Homo sapiens P28065
Y2H
16957778
Intra NCOA1 Q15788 PSMB9 Homo sapiens P28065
Pull Down
16957778
Cross NCOA1 Q15788 Nfkb1 Mus musculus P25799
Y2H
9556555
Cross NCOA1 Q15788 Nfkb1 Mus musculus P25799
Pull Down
9556555
Intra NCOA1 Q15788 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra NCOA1 Q15788 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra NCOA1 Q15788 NR1H3 Homo sapiens Q13133
Y2H
20682316
Intra NCOA1 Q15788 NR1H3 Homo sapiens Q13133
Pull Down
20682316
Intra NCOA1 Q15788 ESR1 Homo sapiens P03372
Y2H
16606617
Intra NCOA1 Q15788 ESR1 Homo sapiens P03372
Pull Down
11682626
Intra NCOA1 Q15788 ESR1 Homo sapiens P03372
Y2H
17627277
Intra NCOA1 Q15788 ESR1 Homo sapiens P03372
Pull Down
16957778
Intra NCOA1 Q15788 RXRA Homo sapiens P19793
X-Ray Diffraction
23602807
Intra NCOA1 Q15788 RXRA Homo sapiens P19793
GMS
21478865
Intra NCOA1 Q15788 RXRA Homo sapiens P19793
Pull Down
20682316
Intra NCOA1 Q15788 RXRA Homo sapiens P19793
Solution Sedimentation
21478865
Intra NCOA1 Q15788 RXRA Homo sapiens P19793
FPS
23602807
Intra NCOA1 Q15788 NR1H4 Homo sapiens Q96RI1-2
SPR
14698205
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rhabdomyosarcoma
Endometrial Hyperplasia
Chondroid Lipoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146288 LXR agonist 2 Agonist / 否
HY-RS09089 NCOA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NCOA1 VGNC VGNC:75145
Mus musculus NCOA1 MGD MGI:1276523
Canis familiaris NCOA1 VGNC VGNC:43659
Rattus norvegicus NCOA1 RGD RGD:1309046
Bos taurus NCOA1 VGNC VGNC:97291
Felis catus NCOA1 VGNC VGNC:68431
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