1. Gene
  2. RXRA - retinoid X receptor alpha Gene

RXRA - retinoid X receptor alpha Gene

中文名称:视黄醇 X 受体α

种属: Homo sapiens

同用名: NR2B1; RXRalpha; RXR-alpha

基因 ID: 6256 | 基因类型: protein coding

关于 RXRA

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,326,455-134,440,585 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 11 paralogues. Ubiquitous expression in skin (RPKM 34.2), fat (RPKM 23.2) and 25 other tissues.

功能概要

类视黄醇 X 受体 (RXR) 和视黄酸受体 (RAR) 是核受体,通过参与视黄酸介导的基因激活来介导类视黄醇的生物学效应。这些受体通过以同源二聚体或异源二聚体的形式与靶基因启动子中的特定序列结合,起到转录因子的作用。由该基因编码的蛋白质是类固醇和甲状腺激素受体转录调节因子超家族的成员。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2014 年 5 月]

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and Thyroid Hormone Receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

RXRA 基因产物(3)

mRNA Protein Name
NM_001291920.2 NP_001278849.1 retinoic acid receptor RXR-alpha isoform b
NM_001291921.2 NP_001278850.1 retinoic acid receptor RXR-alpha isoform c
NM_002957.6 NP_002948.1 retinoic acid receptor RXR-alpha isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding domain binding IDA
IDA: 通过直接分析推断
19043829 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12037571 GOA
enables LBD domain binding IDA
IDA: 通过直接分析推断
19043829 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12037571 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7831303 GOA
enables double-stranded DNA binding IMP
IMP: 通过突变表型推断
19043829 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
12039952 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
7831303 GOA
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
1651173 GOA
enables nuclear vitamin D receptor binding IPI
IPI: 通过物理相互作用推断
17426122 GOA
enables peptide binding IDA
IDA: 通过直接分析推断
19043829 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9653119 GOA
enables retinoic acid binding IDA
IDA: 通过直接分析推断
18690216 GOA
enables retinoic acid-responsive element binding IDA
IDA: 通过直接分析推断
19917671 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11915042 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
18511497 GOA
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
contributes to vitamin D response element binding IDA
IDA: 通过直接分析推断
17426122 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
19043829 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex EXP
EXP: 通过实验结果推断
19167885 GOA
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
1310351 GOA
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
10669605 GOA
located in chromatin IDA
IDA: 通过直接分析推断
9267036 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7990953 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
17426122 GOA
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
10698945 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RXRA 蛋白结构

Nuc_recep-AF1

Nuc_recep-AF1: Nuclear/hormone receptor activator site AF-1 (17 - 127)

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (134 - 202)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (264 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
蛋白主名 其他名称

retinoic acid receptor RXR-alpha

nuclear receptor subfamily 2 group B member 1

RXRA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RXRA P19793 STAT1 Homo sapiens P42224
Y2H
21988832
种属内
RXRA P19793 PPARG Homo sapiens P37231-1
Pull Down
21478865
种属内
RXRA P19793 PPARG Homo sapiens P37231-1
GMS
21478865
种属内
RXRA P19793 PPARG Homo sapiens P37231-1
SAXS
21478865
种属内
RXRA P19793 NR1H2 Homo sapiens P55055-1
SPR
15722453
种属内
RXRA P19793 VDR Homo sapiens P11473
Y2H
21988832
种属内
RXRA P19793 VDR Homo sapiens P11473
GMS
21478865
种属内
RXRA P19793 VDR Homo sapiens P11473
SAXS
21478865
种属内
RXRA P19793 VDR Homo sapiens P11473
Solution Sedimentation
21478865
种属内
RXRA P19793 VDR Homo sapiens P11473
Pull Down
21478865
种属内
RXRA P19793 MED1 Homo sapiens Q15648
Pull Down
9653119
种属内
RXRA P19793 MED25 Homo sapiens Q71SY5
Y2H
17641689
种属内
RXRA P19793 MED25 Homo sapiens Q71SY5
Pull Down
17641689
种属内
RXRA P19793 MED25 Homo sapiens Q71SY5
Anti Bait CoIP
17641689
种属内
RXRA P19793 FUS Homo sapiens P35637
Y2H Pooling
32814053
种属内
RXRA P19793 FUS Homo sapiens P35637
Validated Y2H
32814053
种属内
RXRA P19793 FUS Homo sapiens P35637
Y2H Array
32814053
种属内
RXRA P19793 RARA Homo sapiens P10276
Y2H
21988832
种属内
RXRA P19793 RARA Homo sapiens P10276
PLA
25241761
种属内
RXRA P19793 RARA Homo sapiens P10276
Pull Down
19345331
种属内
RXRA P19793 RARA Homo sapiens P10276
X-Ray Diffraction
10698945
种属内
RXRA P19793 NCOA1 Homo sapiens Q15788
SPR
17673910
种属内
RXRA P19793 NCOA1 Homo sapiens Q15788
Pull Down
20682316
种属内
RXRA P19793 NCOA1 Homo sapiens Q15788
FPS
23602807
种属内
RXRA P19793 BHLHE40 Homo sapiens O14503
Crosslink
29234281
种属内
RXRA P19793 NR1H2 Homo sapiens P55055
GMS
24561505
种属内
RXRA P19793 NR1H2 Homo sapiens P55055
Y2H Array
20211142
种属内
RXRA P19793 NR1H3 Homo sapiens Q13133
SPR
15722453
种属内
RXRA P19793 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
20541701
种属内
RXRA P19793 PIK3R1 Homo sapiens P27986
Anti Tag CoIP
20541701
种属内
RXRA P19793 PIK3R1 Homo sapiens P27986
Confocal
20541701
种属内
RXRA P19793 NCOA2 Homo sapiens Q15596
X-Ray Diffraction
17947383
种属内
RXRA P19793 NCOA2 Homo sapiens Q15596
Y2H
17947383
种属间
RXRA P19793 Ncoa6 Rattus norvegicus Q9JLI4
Pull Down
10866662
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder

Pancreatic Adenocarcinoma

Adenocarcinoma Of The Pancreas

Adenocarcinoma Of Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome

Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure

Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Trichothiodystrophy 7, Nonphotosensitive

TTD7

Nonphotosensitive Trichothiodystrophy 7

Trichothiodystrophy 7, Non-Photosensitive

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RXRA VGNC VGNC:34230
Felis catus RXRA VGNC VGNC:64834
Rattus norvegicus RXRA RGD RGD:3610
Canis familiaris RXRA VGNC VGNC:45817
Mus musculus RXRA MGD MGI:98214
Macaca mulatta RXRA VGNC VGNC:76951