1. Gene
  2. NCOA2 - nuclear receptor coactivator 2 Gene

NCOA2 - nuclear receptor coactivator 2 Gene

中文名称:核受体共激活因子 2

种属: Homo sapiens

同用名: SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75

基因 ID: 10499 | 基因类型: protein coding

关于 NCOA2

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,109,782-70,456,446 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues, 2 paralogues and is associated with 86 phenotypes. Ubiquitous expression in testis (RPKM 5.6), esophagus (RPKM 4.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质可作为核激素受体的转录共激活因子,包括类固醇、甲状腺、类视黄醇和维生素 D 受体。编码的蛋白质作为这些核受体配体依赖性活性的中介因子,在结合同源反应元件时调节它们的靶基因。已发现该基因参与导致与各种癌症中其他基因融合的易位,包括急性髓性白血病中的赖氨酸乙酰转移酶 6A (KAT6A) 基因、急性淋巴细胞白血病中的 ETS 变体 6 (ETV6) 基因,以及他在间充质软骨肉瘤中与 YRPW 基序 1 (HEY1) 基因相关的家族 bHLH 转录因子。可变剪接导致多个转录本变体。[RefSeq 提供,2016 年 3 月]

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with Other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

NCOA2 基因产物(6)

mRNA Protein Name
NM_001321703.2 NP_001308632.1 nuclear receptor coactivator 2 isoform a
NM_001321707.2 NP_001308636.1 nuclear receptor coactivator 2 isoform a
NM_001321711.2 NP_001308640.1 nuclear receptor coactivator 2 isoform b
NM_001321712.2 NP_001308641.1 nuclear receptor coactivator 2 isoform b
NM_001321713.2 NP_001308642.1 nuclear receptor coactivator 2 isoform c
NM_006540.4 NP_006531.1 nuclear receptor coactivator 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aryl hydrocarbon receptor binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
10478845 GOA
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
17363140 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11265755 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11583620 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9430642 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex EXP
EXP: 通过实验结果推断
15258145 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15641800 GOA
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
9430642 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NCOA2 蛋白结构

PAS

PAS: PAS fold (119 - 175)

PAS_11

PAS_11: PAS domain (268 - 378)

SRC-1

SRC-1: Steroid receptor coactivator (636 - 709)

Nuc_rec_co-act

Nuc_rec_co-act: Nuclear receptor coactivator (1071 - 1117)

DUF1518

DUF1518: Domain of unknown function (DUF1518) (1281 - 1338)

  • 0
  • 300
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  • 900
  • 1200
  • 1464 a.a.
蛋白主名 其他名称

nuclear receptor coactivator 2

class E basic helix-loop-helix protein 75

NCOA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NCOA2 Q15596 ESR1 Homo sapiens P03372
Pull Down
11265755
种属内
NCOA2 Q15596 RXRA Homo sapiens P19793
X-Ray Diffraction
24561505
种属内
NCOA2 Q15596 RXRA Homo sapiens P19793
Solution Sedimentation
21478865
种属内
NCOA2 Q15596 RXRA Homo sapiens P19793
GMS
21478865
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mesenchymal Chondrosarcoma

Chondrosarcoma, Mesenchymal

Chondrosarcoma Mesenchymal

Chondrosarcoma

Cartilaginous Cancer

Chondrosarcoma Of Bone

Primary Chondrosarcoma Of The Bone

CHDSA

Fallopian Tube Adenosarcoma

Fallopian Tube Mullerian Adenosarcoma

Fallopian Tube Carcinosarcoma

Fallopian Tube Malignant Mixed Mesodermal Tumor

Fallopian Tube Malignant Mixed Mullerian Tumor

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome

AIS

Testicular Feminization Syndrome

Androgen Receptor Deficiency

Dhtr Deficiency

Dihydrotestosterone Receptor Deficiency

Ar Deficiency

Testicular Feminization

Tfm

Androgen Insensitivity

Androgen-Insensitivity Syndrome

Goldberg-Maxwell Syndrome

Complete Androgen Insensitivity Syndrome

Cais

Feminisation - Testicular

Goldberg - Maxwell Syndrome

Androgen Insensitivity Syndrome, Complete

Morris Syndrome

Ary

AR

Insensitivity Syndrome, Androgen

Androgen Insensitivity Nos

Spindle Cell Rhabdomyosarcoma
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

Hernia, Hiatus

Hiatal Hernia

Hiatus Hernia

Diaphragmatic - Hiatus -Hernia

Hernia, Hiatal

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma

Anaplastic Rhabdomyosarcoma

Pleomorphic Rhabdomyosarcoma, Adult Type

Rhabdomyosarcoma
Progressive Relapsing Multiple Sclerosis

Prms

Progressive-Relapsing Ms

Multiple Sclerosis, Progressive Relapsing

Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules

Ovarian Sex Cord-Stromal Tumor

Stromal Tumor Of Ovary

Periosteal Chondrosarcoma

Juxtacortical Chondrosarcoma

Myxoid Chondrosarcoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas

Glycogen Storage Disease Ia

Von Gierke Disease

Glycogen Storage Disease Type I

Glycogen Storage Disease I

Hepatorenal Form Of Glycogen Storage Disease

Hepatorenal Glycogenosis

Glucose-6-Phosphatase Deficiency

Glycogen Storage Disease, Type I

Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia

GSD1A

Gsd1

Von Gierke'S Disease

Glycogen Storage Disease Type 1a

Glycogen Storage Disease 1a

Glucose-6-Phosphate Transport Defect

Gsd Ia

Deficiency Of Glucose-6-Phosphatase

Glycogenosis Type I

Glucose-6-Phosphatase Deficiency Glycogen Storage Disease

Glycogenosis Type 1

Glucose-6-Phosphate Deficiency

Gsd I

Gsd Type I

G6p Deficiency Type 1a

Gsd Due To G6p Deficiency Type 1a

Gsd Due To G6p Deficiency Type Ia

Gsd Type 1a

Gsdia

Glycogen Storage Disease Due To G6p Deficiency Type Ia

Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a

Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia

Glycogenosis Type Ia

Gsd-Ia

Storage Disease, Glycogen, Type 1a

Glycogen Storage Disease Type Ia

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Spindle Cell Sarcoma

Sarcoma

Sarcoma Spindle Cell

Sarcoma, Spindle Cell

Sarcoma - Category

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus NCOA2 VGNC VGNC:81712
Macaca mulatta NCOA2 VGNC VGNC:75146
Mus musculus NCOA2 MGD MGI:1276533
Canis familiaris NCOA2 VGNC VGNC:43660
Rattus norvegicus NCOA2 RGD RGD:620108
Bos taurus NCOA2 VGNC VGNC:50226