2. Gene
  3. MED1 - mediator complex subunit 1 Gene

MED1 - mediator complex subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：介体复合物亚基 1

种属: Homo sapiens

同用名: PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220

基因 ID: 5469 | 基因类型: protein coding

关于 MED1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,404,285-39,451,263 (from NCBI)

This gene has 5 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in lymph node (RPKM 8.1), appendix (RPKM 7.7) and 25 other tissues.

功能概要

基因转录的激活是一个多步骤过程，由识别 DNA 中转录增强子位点的因素触发。这些因子与共激活因子一起通过 RNA 聚合酶 II 装置指导转录起始。该基因编码的蛋白质是 CRSP (SP1 激活所需的辅因子) 复合物的一个亚基，它与 TFIID 一起是 SP1 有效激活所必需的。这种蛋白质也是其他多亚基复合物的组成部分，例如甲状腺激素受体- (TR-) 相关蛋白，它与 TR 相互作用并促进 TR 在 DNA 模板上与起始因子和辅因子一起发挥功能。它还调节 p53 依赖性细胞凋亡，并且对脂肪生成至关重要。已知这种蛋白质具有自寡聚化的能力。[RefSeq 提供，2008 年 7 月]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent Apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

MED1 基因产物(1)

mRNA Protein Name
NM_004774.4 NP_004765.2 mediator of RNA polymerase II transcription subunit 1

MED1 蛋白结构

Med1

Med1: Mediator of RNA polymerase II transcription subunit 1 (35 - 427)

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  • 1581 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 1

ARC205

MED1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MED1 Q15648 THRA Homo sapiens P10827
Anti Tag CoIP
9653119
Intra MED1 Q15648 THRA Homo sapiens P10827
Pull Down
9653119
Intra MED1 Q15648 VDR Homo sapiens P11473
Solution Sedimentation
21478865
Intra MED1 Q15648 VDR Homo sapiens P11473
GMS
21478865
Intra MED1 Q15648 VDR Homo sapiens P11473
Pull Down
12403843
Intra MED1 Q15648 GATA1 Homo sapiens P15976
Pull Down
17132730
Intra MED1 Q15648 GATA1 Homo sapiens P15976
Y2H
17132730
Intra MED1 Q15648 MED7 Homo sapiens O43513
Anti Tag CoIP
24882805
Intra MED1 Q15648 MED7 Homo sapiens O43513
Anti Tag CoIP
33961781
Intra MED1 Q15648 MED21 Homo sapiens Q13503
Anti Tag CoIP
24882805
Intra MED1 Q15648 RARA Homo sapiens P10276
GMS
21478865
Intra MED1 Q15648 RARA Homo sapiens P10276
SAXS
21478865
Intra MED1 Q15648 RARA Homo sapiens P10276
Solution Sedimentation
21478865
Intra MED1 Q15648 RARA Homo sapiens P10276
Y2H
17641689
Intra MED1 Q15648 ESR1 Homo sapiens P03372
Pull Down
9653119
Intra MED1 Q15648 RXRA Homo sapiens P19793
Solution Sedimentation
21478865
Intra MED1 Q15648 RXRA Homo sapiens P19793
GMS
21478865
Intra MED1 Q15648 RXRA Homo sapiens P19793
SAXS
21478865
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08278 MED1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MED1 VGNC VGNC:31346
Mus musculus MED1 MGD MGI:1100846
Macaca mulatta MED1 VGNC VGNC:74724
Felis catus MED1 VGNC VGNC:68975
Rattus norvegicus MED1 RGD RGD:1559552
Canis familiaris MED1 VGNC VGNC:43117
Others MED1 NCBI
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