1. Gene
  2. PSMB9 - proteasome 20S subunit beta 9 Gene

PSMB9 - proteasome 20S subunit beta 9 Gene

中文名称:蛋白酶体 20S 亚基 β 9

种属: Homo sapiens

同用名: LMP2; PRAAS3; PSMB6i; RING12; beta1i

基因 ID: 5698 | 基因类型: protein coding

关于 PSMB9

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,854,192-32,859,851 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 214 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 72.3), lymph node (RPKM 60.9) and 24 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物,具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成; 2 个环由 7 个α亚基组成,2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中,并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码蛋白酶体 B 型家族的成员,也称为 T1B 家族,是一个 20S 核心 β 亚基。该基因位于 MHC (主要组织相容性复合体) 的 II 类区域。该基因的表达由γ干扰素诱导,该基因产物取代了免疫蛋白酶体中的催化亚基 1 (蛋白酶体β6 亚基) 。需要蛋白水解加工来产生成熟的亚基。[RefSeq 提供,2010 年 3 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (Proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

PSMB9 基因产物(1)

mRNA Protein Name
NM_002800.5 NP_002791.1 proteasome subunit beta type-9 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14733938 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
26524591 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PSMB9 蛋白结构

Proteasome

Proteasome: Proteasome subunit (17 - 198)

  • 0
  • 100
  • 200
  • 219 a.a.
蛋白主名 其他名称

proteasome subunit beta type-9

large multifunctional peptidase 2

PSMB9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PSMB9 P28065 CRYGA Homo sapiens Q24JT5
Validated Y2H
32296183
Intra PSMB9 P28065 LAGE3 Homo sapiens Q14657
MAPPIT
32296183
Intra PSMB9 P28065 LAGE3 Homo sapiens Q14657
Validated Y2H
32296183
Intra PSMB9 P28065 GRIP1 Homo sapiens Q9Y3R0
Anti Bait CoIP
16957778
Intra PSMB9 P28065 PSMB7 Homo sapiens Q99436
Anti Tag CoIP
33961781
Intra PSMB9 P28065 PSMB7 Homo sapiens Q99436
Pull Down
30833792
Intra PSMB9 P28065 PSMB7 Homo sapiens Q99436
Y2H
14733938
Intra PSMB9 P28065 POMP Homo sapiens Q9Y244
Y2H
14733938
Intra PSMB9 P28065 POMP Homo sapiens Q9Y244
Anti Tag CoIP
33961781
Intra PSMB9 P28065 POMP Homo sapiens Q9Y244
Anti Tag CoIP
28514442
Intra PSMB9 P28065 POMP Homo sapiens Q9Y244
Pull Down
30833792
Intra PSMB9 P28065 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra PSMB9 P28065 NCOA3 Homo sapiens Q9Y6Q9
Y2H
16957778
Cross PSMB9 P28065 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H Prey Pooling
18985028
Cross PSMB9 P28065 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross PSMB9 P28065 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H Prey Pooling
18985028
Cross PSMB9 P28065 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Proteasome-Associated Autoinflammatory Syndrome 3

Proteasome-Associated Autoinflammatory Syndrome 3, Digenic

PRAAS3

Proteasome-Associated Autoinflammatory Syndrome 3 And Digenic Forms

Nasopharyngeal Disease

Nasopharyngeal Diseases

Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy

Panniculitis

Nodular Panniculitis

Proteasome-Associated Autoinflammatory Syndrome

Aldd Syndrome

Autoinflammation-Lipodystrophy-Dermatosis Syndrome

Praas

Proteasome Disability Syndrome

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Graves' Disease

Graves Disease

Exophthalmic Goiter

Basedow'S Disease

Grave'S Disease

Basedow Disease

Toxic Diffuse Goiter

Graves' Hyperthyroidism

Parry Disease

Autoimmune Hyperthyroidism

Toxic Multinodular Goiter

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx

Oral Hairy Leukoplakia

Hairy Leukoplakia

Leukoplakia, Hairy

Hairy Leucoplakia

Leiomyosarcoma

Leiomyosarcomas

Immunodeficiency 12

Combined Immunodeficiency Due To Malt1 Deficiency

IMD12

Immunodeficiency, Type 12

Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive

Bizarre Leiomyoma

Atypical Leiomyoma

Pleomorphic Leiomyoma

Symplastic Leiomyoma

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Keratinizing Squamous Cell Carcinoma

Squamous Cell Carcinoma, Keratinizing

Keratinizing Epidermoid Carcinoma

Hashimoto Thyroiditis

Autoimmune Thyroiditis

Hashimoto Struma

Hashimoto'S Thyroiditis

Chronic Lymphocytic Thyroiditis

Lymphocytic Thyroiditis

Hashimoto Disease

Ht

Hashimoto'S Disease

Hashimoto'S Syndrome

Hypothyroidism, Autoimmune

Autoimmune Chronic Lymphocytic Thyroiditis

Chronic Lymphocytic Thyroiditides

Hashimoto Syndrome

Hashimotos Thyroiditis

Hashimoto Thyroiditis, Susceptibility To

Thyroiditis, Autoimmune

Lymphomatous Thyroiditis

Lymphoid Thyroiditis

Chronic Lymphadenoid Thyroiditis

Autoimmune Lymphocytic Chronic Thyroiditis

Goitre Lymphomatosa

Hashitoxicosis

Hashimoto Hypothyroidism

Lymphadenoid Goitre

Struma Lymphomatosa

Hyperthyroidism With Hashimoto Disease

Hashimoto Thyrotoxicosis

Thyrotoxicosis Due To Hashimoto Thyroiditis

Struma Lymphomatosis

Lymphadenoid Struma

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified

Pfeiffer Syndrome

Infectious Mononucleosis

Acs5

Craniofacial-Skeletal-Dermatologic Dysplasia

Acs V

Noack Syndrome

Gammaherpesviral Mononucleosis

Acrocephalosyndactyly Type 5

Pfeiffer Syndrome Type 3

Acrocephalosyndactyly, Type V

Glandular Fever

Pfeiffer Type Acrocephalosyndactyly

Pfeiffer Syndrome Type 2

Acrocephalosyndactylia Type V

Filatov'S Disease

Monocytic Angina

Mononucleosis

Pfeiffer'S Disease

Acsv

Acrocephalosyndactyly, Type 5

Craniofacial-Skeletal-Dermatologic Syndrome

Pfeiffer Syndrome Type 1

Classic Pfeiffer Syndrome

PS

Pfeiffer Syndrome Variant

Dysplasia, Craniofacial-Skeletal-Dermatologic

Pfeiffer

Kissing Disease

Infectious Adenitis

Pfeiffer Disease

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm

Neoplasm Of Mature B-Cells

Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Liver Leiomyosarcoma

Leiomyosarcoma Of The Liver

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PSMB9 VGNC VGNC:33453
Rattus norvegicus PSMB9 RGD RGD:3427
Canis familiaris PSMB9 VGNC VGNC:45100
Mus musculus PSMB9 MGD MGI:1346526
Macaca mulatta PSMB9 VGNC VGNC:76447
Others PSMB9 NCBI