2. Gene
  3. NCOA3 - nuclear receptor coactivator 3 Gene

NCOA3 - nuclear receptor coactivator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体共激活因子 3

种属: Homo sapiens

同用名: ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42

基因 ID: 8202 | 基因类型: protein coding

关于 NCOA3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:47,501,887-47,656,872 (from NCBI)

This gene has 5 transcripts (splice variants), 269 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 20.8), placenta (RPKM 19.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种核受体共激活因子，可与核激素受体相互作用，增强其转录激活功能。编码的蛋白质具有组蛋白乙酰转移酶活性，并募集 p300/CBP 相关因子和 CREB 结合蛋白作为多亚基共激活复合物的一部分。这种蛋白质最初存在于细胞质中，但在磷酸化后转移到细胞核中。已发现该基因编码不同亚型的几种转录变体。此外，在编码蛋白的 C 末端发现了一个多态性重复区域。[RefSeq 提供，2010 年 3 月]

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has Histone Acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

NCOA3 基因产物(4)

mRNA Protein Name
NM_001174087.2 NP_001167558.1 nuclear receptor coactivator 3 isoform c
NM_001174088.2 NP_001167559.1 nuclear receptor coactivator 3 isoform d
NM_006534.4 NP_006525.2 nuclear receptor coactivator 3 isoform b
NM_181659.3 NP_858045.1 nuclear receptor coactivator 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disordered domain specific binding IPI
IPI: 通过物理相互作用推断
11823864 GOA
enables histone acetyltransferase activity IDA
IDA: 通过直接分析推断
9267036 GOA
enables nuclear receptor binding IDA
IDA: 通过直接分析推断
9267036 GOA
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
18798693 GOA
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
9267036 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11279242 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
9238002 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
17223341 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to estradiol stimulus IDA
IDA: 通过直接分析推断
15831516 GOA
involved in positive regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
17082781 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9267036 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17082781 GOA
involved in retinoic acid receptor signaling pathway IDA
IDA: 通过直接分析推断
9267036 GOA
involved in vitamin D receptor signaling pathway IDA
IDA: 通过直接分析推断
9267036 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
9267036 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17223341 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17223341 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19917671 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
11823864 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOA3 蛋白结构

PAS

PAS: PAS fold (116 - 173)

PAS_11

PAS_11: PAS domain (265 - 375)

SRC-1

SRC-1: Steroid receptor coactivator (616 - 704)

Nuc_rec_co-act

Nuc_rec_co-act: Nuclear receptor coactivator (1045 - 1095)

DUF1518

DUF1518: Domain of unknown function (DUF1518) (1287 - 1344)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1420 a.a.
蛋白主名 其他名称

nuclear receptor coactivator 3

CBP-interacting protein

NCOA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross NCOA3 Q9Y6Q9 Myocd Mus musculus Q8VIM5-1
Pull Down
17360478
Cross NCOA3 Q9Y6Q9 Myocd Mus musculus Q8VIM5-1
Anti Tag CoIP
17360478
Intra NCOA3 Q9Y6Q9 CARM1 Homo sapiens Q86X55
Anti Bait CoIP
26267537
Cross NCOA3 Q9Y6Q9 Vdr Mus musculus P48281
Y2H
12529369
Intra NCOA3 Q9Y6Q9 PSME3 Homo sapiens P61289
Anti Tag CoIP
16439211
Intra NCOA3 Q9Y6Q9 PSME3 Homo sapiens P61289
Anti Bait CoIP
16439211
Intra NCOA3 Q9Y6Q9 PSME3 Homo sapiens P61289
Pull Down
16439211
Intra NCOA3 Q9Y6Q9 PSMB9 Homo sapiens P28065
Pull Down
16957778
Intra NCOA3 Q9Y6Q9 PSMB9 Homo sapiens P28065
Anti Bait CoIP
16957778
Intra NCOA3 Q9Y6Q9 PTEN Homo sapiens P60484
Anti Bait CoIP
23514585
Intra NCOA3 Q9Y6Q9 SPOP Homo sapiens O43791
Anti Tag CoIP
21577200
Intra NCOA3 Q9Y6Q9 SPOP Homo sapiens O43791
Pull Down
21577200
Intra NCOA3 Q9Y6Q9 SPOP Homo sapiens O43791
Anti Bait CoIP
21577200
Intra NCOA3 Q9Y6Q9 IKBKB Homo sapiens O14920
CoIP
11971985
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Endometrial Hyperplasia
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Teeth Hard Tissue Disease
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09091 NCOA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NCOA3 VGNC VGNC:31921
Felis catus NCOA3 VGNC VGNC:68432
Macaca mulatta NCOA3 VGNC VGNC:75147
Rattus norvegicus NCOA3 RGD RGD:620109
Canis familiaris NCOA3 VGNC VGNC:54658
Mus musculus NCOA3 MGD MGI:1276535
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