2. Gene
  3. SPOP - speckle type BTB/POZ protein Gene

SPOP - speckle type BTB/POZ protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：斑点型 BTB/POZ 蛋白

种属: Homo sapiens

同用名: TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF

基因 ID: 8405 | 基因类型: protein coding

关于 SPOP

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,598,884-49,678,163 (from NCBI)

This gene has 25 transcripts (splice variants), 340 orthologues, 11 paralogues and is associated with 91 phenotypes. Ubiquitous expression in prostate (RPKM 17.8), esophagus (RPKM 16.2) and 25 other tissues.

功能概要

该基因编码的蛋白质可能调节死亡相关蛋白 6 (DAXX) 的转录抑制活性，DAXX 与组蛋白脱乙酰酶、核心组蛋白和其他组蛋白相关蛋白相互作用。在小鼠中，编码的蛋白质与 macroH2A1.2 的推定亮氨酸拉链结构域结合，macroH2A1.2 是一种变体 H2A 组蛋白，在失活的 X 染色体上富集。该蛋白的 BTB/POZ 结构域已在其他蛋白中显示可介导转录抑制并与组蛋白脱乙酰酶共抑制复合物的成分相互作用。该基因的可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

SPOP 基因产物(9)

mRNA Protein Name
NM_001007226.1 NP_001007227.1 speckle-type POZ protein
NM_001007227.1 NP_001007228.1 speckle-type POZ protein
NM_001007228.2 NP_001007229.1 speckle-type POZ protein
NM_001007229.1 NP_001007230.1 speckle-type POZ protein
NM_001007230.1 NP_001007231.1 speckle-type POZ protein
NM_001370730.1 NP_001357659.1 speckle-type POZ protein
NM_001370731.1 NP_001357660.1 speckle-type POZ protein
NM_001370732.1 NP_001357661.1 speckle-type POZ protein
NM_003563.3 NP_003554.1 speckle-type POZ protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22632832 GOA
enables molecular function inhibitor activity EXP
EXP: 通过实验结果推断
31624231 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
11279055 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
22085717 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
14528312 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul3-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
14528312 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22085717 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPOP 蛋白结构

MATH

MATH: MATH domain (38 - 163)

BTB

BTB: BTB/POZ domain (193 - 296)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

speckle-type POZ protein

HIB homolog 1

SPOP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SPOP O43791 DUSP7 Homo sapiens Q16829
Anti Tag CoIP
24656772
Intra SPOP O43791 DUSP7 Homo sapiens Q16829
Ubiquitinase Assay
24656772
Intra SPOP O43791 MYD88 Homo sapiens Q99836
Y2H
21988832
Intra SPOP O43791 MYD88 Homo sapiens Q99836
Anti Tag CoIP
21988832
Intra SPOP O43791 MYD88 Homo sapiens Q99836
Pull Down
21988832
Intra SPOP O43791 MYD88 Homo sapiens Q99836
Confocal
21988832
Intra SPOP O43791 CUL3 Homo sapiens Q13618
ITC
22632832
Intra SPOP O43791 CUL3 Homo sapiens Q13618
X-Ray Diffraction
22632832
Intra SPOP O43791 CUL3 Homo sapiens Q13618
GMS
22632832
Intra SPOP O43791 PTEN Homo sapiens P60484
Anti Tag CoIP
24656772
Intra SPOP O43791 PTEN Homo sapiens P60484
Ubiquitinase Assay
24656772
Intra SPOP O43791 DAXX Homo sapiens Q9UER7
Y2H Array
21988832
Intra SPOP O43791 DAXX Homo sapiens Q9UER7
Y2H
21988832
Intra SPOP O43791 DAXX Homo sapiens Q9UER7
Confocal
21988832
Intra SPOP O43791 NCOA3 Homo sapiens Q9Y6Q9
Pull Down
21577200
Intra SPOP O43791 NCOA3 Homo sapiens Q9Y6Q9
Anti Tag CoIP
21577200
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nabais Sa-De Vries Syndrome, Type 1

Neurodevelopmental Disorder With Microcephaly And Dysmorphic Facies

NSDVS1

Nedmidf

Nabais Sa-De Vries Syndrome 1
Nabais Sa-De Vries Syndrome, Type 2

Neurodevelopmental Disorder With Relative Macrocephaly And With Or Without Cardiac Or Endocrine Anomalies

NSDVS2

Nedmace

Nabais Sa-De Vries Syndrome 2
Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1
Uterine Corpus Endometrial Carcinoma
Joubert Syndrome 32

JBTS32
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-136938 NEO2734 Inhibitor 99.63% Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122615 SPOP-IN-6b Inhibitor 99.58% 否
HY-122615B SPOP-IN-6b dihydrochloride Inhibitor 99.70% 否
HY-161251 SPOP-IN-2 / 否
HY-156382 SPOP-IN-1 Inhibitor 99.71% 否
HY-122615A SPOP-IN-6b hydrochloride Inhibitor / 否
HY-RS13700 SPOP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SPOP VGNC VGNC:65643
Mus musculus SPOP MGD MGI:1343085
Bos taurus SPOP VGNC VGNC:35229
Rattus norvegicus SPOP RGD RGD:1311613
Canis familiaris SPOP VGNC VGNC:46753
Macaca mulatta SPOP VGNC VGNC:77863
Others SPOP NCBI
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