DAXX - death domain associated protein Gene

中文名称：死亡域相关蛋白

种属: Homo sapiens

同用名: DAP6; EAP1; BING2; SMIM40

基因 ID: 1616 | 基因类型: protein coding

关于 DAXX

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,318,558-33,322,959 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 189 orthologues and is associated with 83 phenotypes. Ubiquitous expression in testis (RPKM 26.2), lymph node (RPKM 25.5) and 25 other tissues.

功能概要

该基因编码一种多功能蛋白，存在于细胞核和细胞质的多个位置。它与多种蛋白质相互作用，例如凋亡抗原 Fas、着丝粒蛋白 C 和成红细胞增多症病毒 E26 致癌基因同系物 1 转录因子。在细胞核中，编码的蛋白质作为一种有效的转录抑制因子发挥作用，与 sumoylated 转录因子结合。通过将这种蛋白质螯合到早幼粒细胞白血病核体或核仁中，可以减轻其抑制作用。该蛋白质还与 G2 期的着丝粒结合。在细胞质中，编码的蛋白质可能起到调节细胞凋亡的作用。该蛋白的亚细胞定位和功能受翻译后修饰的调节，包括苏木化、磷酸化和多聚泛素化。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 11 月]

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as Apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate Apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

DAXX 基因产物(4)

mRNA	Protein	Name
NM_001141969.2	NP_001135441.1	death domain-associated protein 6 isoform a
NM_001141970.2	NP_001135442.1	death domain-associated protein 6 isoform b
NM_001254717.2	NP_001241646.1	death domain-associated protein 6 isoform c
NM_001350.5	NP_001341.1	death domain-associated protein 6 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: 通过直接分析推断	10698492	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	16845383	GOA
enables histone binding	IDA IDA: 通过直接分析推断	12140263	GOA
enables molecular condensate scaffold activity	EXP EXP: 通过实验结果推断	30244836	GOA
enables nuclear androgen receptor binding	IPI IPI: 通过物理相互作用推断	15572661	GOA
enables p53 binding	IPI IPI: 通过物理相互作用推断	16845383	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9215629	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	10698492	GOA
enables protein kinase activator activity	IGI IGI: 通过遗传相互作用推断	15983381	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15983381	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	15016915	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	12140263	GOA
enables transcription corepressor activity	IMP IMP: 通过突变表型推断	17081986	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	10698492	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	16845383	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in JNK cascade	IDA IDA: 通过直接分析推断	9215629	GOA
involved in androgen receptor signaling pathway	IDA IDA: 通过直接分析推断	15572661	GOA
involved in cellular response to cadmium ion	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to copper ion	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to diamide	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to heat	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to sodium arsenite	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to unfolded protein	IDA IDA: 通过直接分析推断	15016915	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	20651253	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: 通过直接分析推断	9215629	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12140263	GOA
involved in negative regulation of gene expression	IDA IDA: 通过直接分析推断	10698492	GOA
involved in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	IGI IGI: 通过遗传相互作用推断	15983381	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	20504901	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: 通过遗传相互作用推断	15983381	GOA
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15878163	GOA
involved in regulation of gene expression	IDA IDA: 通过直接分析推断	10698492	GOA
involved in regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	18566590	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in PML body	IDA IDA: 通过直接分析推断	10669754	GOA
located in chromosome, centromeric region	IDA IDA: 通过直接分析推断	10504293	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	15572661	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15878163	GOA
located in nucleus	IMP IMP: 通过突变表型推断	10698492	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAXX 蛋白结构

Daxx

0
200
400
600
740 a.a.

蛋白主名

其他名称

death domain-associated protein 6

CENP-C binding protein

DAXX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	DAXX	Q9UER7	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	DAXX	Q9UER7	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Array	32296183
Intra	DAXX	Q9UER7	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Y2H Array	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	TAP	24981860
Intra	DAXX	Q9UER7	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	DAXX	Q9UER7	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AIRE	Homo sapiens	O43918	Confocal	20185822
Intra	DAXX	Q9UER7	AIRE	Homo sapiens	O43918	Y2H	20185822
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	DAXX	Q9UER7	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	DAXX	Q9UER7	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Cross	DAXX	Q9UER7	Ripk3	Mus musculus	Q9QZL0	Pull Down	23260419
Intra	DAXX	Q9UER7	ZBTB2	Homo sapiens	Q8N680	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	ZBTB2	Homo sapiens	Q8N680	Y2H Array	32296183
Intra	DAXX	Q9UER7	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	DAXX	Q9UER7	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	DAXX	Q9UER7	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	DAXX	Q9UER7	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-5	Homo sapiens	Q6NXT2	Y2H Array	32296183
Intra	DAXX	Q9UER7	H3-5	Homo sapiens	Q6NXT2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Imaging	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	CoIP	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Y2H	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	IF	14517282
Intra	DAXX	Q9UER7	TGFBR2	Homo sapiens	P37173	Y2H	11483955
Cross	DAXX	Q9UER7	Fas	Mus musculus	P25446	Y2H	9215629
Cross	DAXX	Q9UER7	Fas	Mus musculus	P25446	Pull Down	9215629
Cross	DAXX	Q9UER7	Pax5	Mus musculus	Q02650	Pull Down	11799127
Intra	DAXX	Q9UER7	HDAC2	Homo sapiens	Q92769	GMS	12140263
Intra	DAXX	Q9UER7	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	BFG-2H	27107012
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	27107012
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Tag CoIP	18566590
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Confocal	16845383
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	TAP	24981860
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	16810318
Intra	DAXX	Q9UER7	TSG101	Homo sapiens	Q99816	CoIP	15033475
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Pull Down	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	22609355
Intra	DAXX	Q9UER7	HSPB1	Homo sapiens	P04792	PLA	25241761
Intra	DAXX	Q9UER7	HSPB1	Homo sapiens	P04792	Pull Down	11003656
Intra	DAXX	Q9UER7	RSL1D1	Homo sapiens	O76021	Crosslink	30021884
Intra	DAXX	Q9UER7	RSL1D1	Homo sapiens	O76021	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	IF	14557665
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Tag CoIP	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	IF	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	PLA	25241761
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Bait CoIP	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Y2H	15364927
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	Anti Tag CoIP	18566590
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	IF	18566590
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Pull Down	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	15364927
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Fluorescence	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	18583933
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Display Tech	20195357
Intra	DAXX	Q9UER7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	DAXX	Q9UER7	ZFAT	Homo sapiens	Q9P243	Anti Tag CoIP	36162510
Intra	DAXX	Q9UER7	ZFAT	Homo sapiens	Q9P243	Anti Bait CoIP	36162510
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Bait CoIP	24651726
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Imaging	12953102
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	TAP	24981860
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Tag CoIP	26496610
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	CoIP	12953102
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23-4	Imaging	16810318
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Confocal	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Pull Down	11003656
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Anti Bait CoIP	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	CoIP	9743501
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	PLA	25241761
Intra	DAXX	Q9UER7	FAS	Homo sapiens	P25445	PLA	25241761
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	STAT3	Homo sapiens	P40763	Confocal	16331268
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DAXX	Q9UER7	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AR	Homo sapiens	P10275	Anti Bait CoIP	15572661
Intra	DAXX	Q9UER7	AR	Homo sapiens	P10275	Y2H	15572661
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	18583933
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Y2H	18583933
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Confocal	18583933
Cross	DAXX	Q9UER7	Hipk1	Mus musculus	O88904	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Y2H	21988832
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Y2H	21573799
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Anti Tag CoIP	21573799
Intra	DAXX	Q9UER7	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	DAXX	Q9UER7	RELA	Homo sapiens	Q04206	Confocal	17362989
Intra	DAXX	Q9UER7	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	KCTD4	Homo sapiens	Q8WVF5	Y2H Array	32296183
Intra	DAXX	Q9UER7	KCTD4	Homo sapiens	Q8WVF5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	SPOP	Homo sapiens	O43791	Anti Tag CoIP	21988832
Intra	DAXX	Q9UER7	SPOP	Homo sapiens	O43791	Y2H	21573799
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	DAXX	Q9UER7	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
Intra	DAXX	Q9UER7	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	11112409
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	23395904
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	23395904
Intra	DAXX	Q9UER7	UBE2I	Homo sapiens	P63279	Pull Down	23395904
Intra	DAXX	Q9UER7	CREBBP	Homo sapiens	Q92793	CoIP	11799127
Intra	DAXX	Q9UER7	USH1G	Homo sapiens	Q495M9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	USH1G	Homo sapiens	Q495M9	Y2H Array	32296183
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	Anti Tag CoIP	16569639
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	IF	16569639
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	Y2H	16569639
Cross	DAXX	Q9UER7	HSPB1	Cricetulus longicaudatus	P15991	Y2H	11003656
Cross	DAXX	Q9UER7	HSPB1	Cricetulus longicaudatus	P15991	Pull Down	11003656
Cross	DAXX	Q9UER7	E1B	Human adenovirus C	P03244	Y2H	14557665
Cross	DAXX	Q9UER7	E1B	Human adenovirus C	P03244	Anti Bait CoIP	14557665
Cross	DAXX	Q9UER7	e1b55_ade05	Human adenovirus C	P03243	IF	14557665
Cross	DAXX	Q9UER7	e1b55_ade05	Human adenovirus C	P03243	Anti Bait CoIP	14557665
Cross	DAXX	Q9UER7	mtp_ebvb9	Epstein-Barr virus	P03179	Anti Bait CoIP	22102817

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gastric Neuroendocrine Neoplasm

Gastric Neuroendocrine Tumor	Neuroendocrine Tumor Of The Stomach
Neuroendocrine Tumor Of Stomach	Gnet
Gastric Net	Net Of Stomach

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Alpha-Thalassemia Myelodysplasia Syndrome

ATMDS	Acquired Hemoglobin H Disease
Alpha-Thalassemia Myelodysplasia Syndrome, Somatic	Acquired Hbh Disease
Alpha-Thalassemia-Myelodysplastic Syndrome	Hemoglobin H Disease, Acquired
Acquired Alpha-Thalassemia With Myelodysplastic Syndrome	Hemoglobin H Disease Acquired
Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic

Glottis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Glottis

Squamous Cell Carcinoma Of Glottis

Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

Atr-X Syndrome	Atr, Nondeletion Type
Alpha-Thalassemia X-Linked Intellectual Disability Syndrome	Atrx Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type	Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked
X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome	Xlmr Hypotonic Face Syndrome
Alpha Thalassemia X-Linked Intellectual Disability Syndrome	Alpha Thalassemia X-Linked Mental Retardation Syndrome
Alpha Thalassemia/Mental Retardation, X-Linked	Alpha-Thalassemia X-Linked Mental Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type	X-Linked Alpha-Thalassemia/Mental Retardation Syndrome
Xlmr-Hypotonic Face Syndrome	Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked

Thalassemia

Sickle-Cell Thalassemia With Crisis	Sickle-Cell Thalassemia Without Crisis
Thalassemia Hb-S Disease With Crisis	Thalassemia Hb-S Disease Without Crisis
Thalassemias	Hereditary Leptocytosis
Haemoglobin Thalassaemia Disorder	Thalassaemia Syndrome
Thalassaemia Nos	Thalassemia Variants

Pancreatic Endocrine Carcinoma

Carcinoma Of Endocrine Pancreas	Islet Cell Carcinoma
Malignant Neoplasm Of Islets Of Langerhans	Pancreatic Neuroendocrine Carcinoma
Carcinoma Islet Cell	Carcinoma, Islet Cell

Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type	Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Atr Syndrome Linked To Chromosome 16	Atr Syndrome, Deletion Type
Atr-16 Syndrome	Alpha Thalassemia-Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type	Alpha-Thalassemia/Mental Retardation Syndrome, Type 1
Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor	Neuroendocrine Tumor Of Pancreas
Pnet	Pancreatic Net
Pancreatic Endocrine Tumor	Well-Differentiated Nen Of Pancreas
Well-Differentiated Neuroendocrine Neoplasm Of Pancreas	Well-Differentiated Pancreatic Nen
Well-Differentiated Pancreatic Neuroendocrine Neoplasm	Endocrine Pancreas Cancer
Islet Cell Neoplasm	Islet Cell Tumour
Malignant Pancreatic Endocrine Tumor	Malignant Pancreatic Endocrine Tumour
Malignant Tumor Of Endocrine Pancreas	Malignant Tumour Of Endocrine Pancreas
Pancreatic Endocrine Neoplasm	Pancreatic Neuroendocrine Neoplasm
Adenoma, Islet Cell	Well Differentiated Pancreatic Endocrine Tumor
Malignant Neoplasm Of Endocrine Pancreas	Pancreatic Endocrine Carcinoma

Cutis Laxa, Autosomal Dominant 1

Cutis Laxa, Autosomal Dominant	Autosomal Dominant Cutis Laxa
ADCL1	Adcl
Autosomal Dominant Cutis Laxa 1	Cutis Laxa, Autosomal Dominant, 1
Cutis Laxa, Autosomal Dominant, Type 1

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03535	DAXX Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DAXX	VGNC	VGNC:39777
Rattus norvegicus	DAXX	RGD	RGD:621227
Bos taurus	DAXX	VGNC	VGNC:27884
Macaca mulatta	DAXX	VGNC	VGNC:71737
Mus musculus	DAXX	MGD	MGI:1197015

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