MKRN1 - makorin ring finger protein 1 Gene

中文名称：makorin 无名指蛋白 1

种属: Homo sapiens

同用名: RNF61

关于 MKRN1

功能概要

该基因编码的蛋白质属于一类新型锌指蛋白。编码的蛋白质作为转录共调节因子和 E3 泛素连接酶发挥作用，促进靶蛋白的泛素化和蛋白酶体降解。该基因编码的蛋白质被认为可以调节 RNA 聚合酶 II 催化的转录。这种蛋白质的 E3 泛素连接酶活性的底物包括西尼罗河病毒的衣壳蛋白和端粒酶核糖核蛋白的催化亚基。该蛋白通过调节细胞周期调节因子 p21 和肿瘤抑制蛋白 p53 来控制细胞周期停滞和细胞凋亡。该基因的假基因存在于 1、3、9、12 和 20 号染色体以及 X 染色体上。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin Ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin Ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the Telomerase ribonucleoprotein. This protein controls cell cycle arrest and Apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]