2. Gene
  3. AMOTL2 - angiomotin like 2 Gene

AMOTL2 - angiomotin like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管动蛋白样 2

种属: Homo sapiens

同用名: LCCP

基因 ID: 51421 | 基因类型: protein coding

关于 AMOTL2

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,355,345-134,375,417 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues.

功能概要

血管动蛋白是一种结合血管抑制素的蛋白质，血管抑制素是新血管形成 (血管生成) 的循环抑制剂。血管动蛋白在体外介导血管抑制素对内皮细胞迁移和管形成的抑制。由该基因编码的蛋白质与血管动蛋白有关，是动蛋白家族的一员。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 7 月]

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AMOTL2 基因产物(4)

mRNA Protein Name
NM_001278683.1 NP_001265612.1 angiomotin-like protein 2 isoform 1
NM_001278685.2 NP_001265614.1 angiomotin-like protein 2 isoform 3
NM_001363943.2 NP_001350872.1 angiomotin-like protein 2 isoform 4
NM_016201.4 NP_057285.3 angiomotin-like protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein localization IDA
IDA: 通过直接分析推断
23911299 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23911299 GOA
located in podosome IDA
IDA: 通过直接分析推断
23525008 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AMOTL2 蛋白结构

Angiomotin_C

Angiomotin_C: Angiomotin C terminal (482 - 691)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

angiomotin-like protein 2

Leman coiled-coil protein

AMOTL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AMOTL2 Q9Y2J4 RAD51D Homo sapiens O75771
Y2H Array
31515488
Intra AMOTL2 Q9Y2J4 SH3RF2 Homo sapiens Q8TEC5
Y2H Array
31515488
Intra AMOTL2 Q9Y2J4 RNF20 Homo sapiens Q5VTR2
Y2H Array
31515488
Intra AMOTL2 Q9Y2J4 PSMC3 Homo sapiens P17980
Anti Tag CoIP
24255178
Intra AMOTL2 Q9Y2J4 GSTM5 Homo sapiens P46439
Y2H Array
31515488
Intra AMOTL2 Q9Y2J4 NDC80 Homo sapiens O14777
Y2H Array
29892012
Intra AMOTL2 Q9Y2J4 NDC80 Homo sapiens O14777
Y2H Array
31515488
Intra AMOTL2 Q9Y2J4 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra AMOTL2 Q9Y2J4 MAGOHB Homo sapiens Q96A72
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00665 AMOTL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AMOTL2 VGNC VGNC:37837
Rattus norvegicus AMOTL2 RGD RGD:70977
Bos taurus AMOTL2 VGNC VGNC:25872
Felis catus AMOTL2 VGNC VGNC:59771
Mus musculus AMOTL2 MGD MGI:1929286
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